KAKU M, INOUE M, FARRELL DJ, LEE K, LEE N; Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. C2-1266.

Tohoku Univ., Sendai, Japan.

BACKGROUND: The largest increases in antimicrobial resistance have been seen in the Far East (FE). Prevalence of resistance in FE is compared with global prevalence, using PROTEKT data from the first 3 years (Y1: 1999-2000; Y2: 2000-1; Y3: 2001-2). METHODS: Streptococcus pneumoniae (SPN), Haemophilus influenzae (HI), and Streptococcus pyogenes (SPY) isolates were collected from patients with community-acquired RTIs. Antimicrobial MICs were determined using NCCLS methods. Macrolide resistance (MAC-R) mechanisms were identified by PCR. RESULTS: SPN isolates collected in Y1, Y2 and Y3 respectively were: FE (total): 515, 795 and 1014; Hong Kong (HK): 70, 58 and 74; Japan: 308, 627 and 817; S. Korea (SK): 137, 110 and 123. Resistance rates to penicillin (PEN-R, >/= 2 mg/L), erythromycin (ERY-R, >/= 1 mg/L) and levofloxacin (FQR, >/= 8 mg/L) were higher in FE than globally (n=3362, 4256 and 4033). FQR was particularly high (>/= 10.8%) in HK. Numbers of SPN isolates with erm(B)- and mef(A)-mediated MAC-R were comparable; however, in SK >35% of ERY-R isolates carried both mechanisms (compared with <10% global). ERY-R among SPY from SK was 2-3 x the global rate (19->30% vs <14%). In FE, telithromycin (TEL) inhibited >/= 99.7% SPN at /= 99.4% HI at Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Bacterial Agents
• Anti-Infective Agents
• Erythromycin
• Far East
• Haemophilus Infections
• Haemophilus influenzae
• Hong Kong
• Humans
• In Vitro
• Japan
• Ketolides
• Korea
• Microbial Sensitivity Tests
• Penicillins
• Respiratory Tract Infections
• Streptococcus pneumoniae
• Streptococcus pyogenes
• telithromycin

Other ID:

• GWAIDS0026661

UI: 102266285

From Meeting Abstracts