Constans J, Pellegrin JL, Delmas-Beauvieux MC, Sergeant C, Peuchant E, Pellegrin I, Simonoff M, Fleury H, Leng B, Conri C; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 3rd Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 3rd 1996 Wash D C. 1996 Jan 28-Feb 1; 3rd: 122.
Centre Hospitalier Universitaire, Bordeaux, France.
We report the results of one year supplementation with selenium or beta-carotene in 52 patients with CD4 cell count less than 300/mm 3 : 15 supplemented with 60 mg (beta- carotene/d (betaC), 15 with 100 micrograms selenium/d (Se), and 22 non supplemented (C). Subjects had a clinical and biological evaluation every 3 months (MO, M3, M6, M9, M12). At MO, M6 and M12 the antioxidant status was determined (glutathion, superoxide dismutase-SOD, glutathion peroxidase-Gpx, catalase, plasma selenium and beta-carotene). Results: At one year there was no difference between the groups for opportunistic infections or death or for the CD4 cell count. However beta2 microglobulin decreased in the Se group and increased in the C group. In Se group beta2 microglobulin became lower than in C at M3, M6 and M12 (p= 0.018, 0.025 and 0.055 respectively). Gpx and plasma Se increased only in the Se group (p=0.04 at M6 and 0.02 at M12 respectively) while they decrease in the C group (p= 0.04 at M12 for Gpx). Gpx non-significant increased in the betaC group. Total glutathion decreased in the increased in the Se and betaC groups. Supplementation with results in an improvement of some natural antioxidant be beneficial for the immune system while the effects seem more limited. Larger trials are needed with selenium.
Publication Types:
Keywords:
- Antioxidants
- Catalase
- Dietary Supplements
- Glutathione
- Glutathione Peroxidase
- Humans
- Selenium
- Superoxide Dismutase
- beta Carotene
Other ID:
UI: 102216422
From Meeting Abstracts