US 7,468,434 B2 | ||
Diazene-bridge crown ether lithium compounds and methods for their use | ||
Paul Michel Georges Vanhoutte, Hong Kong (Hong Kong Special Administrative Region of the People's Republic of China, The); Chi-Ming Che, Hong Kong (Hong Kong Special Administrative Region of the People's Republic of China, The); Kwok-Fai So, Pokfulam (Hong Kong Special Administrative Region of the People's Republic of China, The); and Iona Hiu Tung Sham, Chai Wan (Hong Kong Special Administrative Region of the People's Republic of China, The) | ||
Assigned to The University of Hong Kong, Hong Kong (China) | ||
Filed on Dec. 21, 2005, as Appl. No. 11/313,513. | ||
Claims priority of provisional application 60/638100, filed on Dec. 22, 2004. | ||
Prior Publication US 2007/0298127 A1, Dec. 27, 2007 | ||
Int. Cl. C07D 225/00 (2006.01) |
U.S. Cl. 540—450 [540/467; 540/468; 540/469] | 8 Claims |
1. A method for protecting against the degeneration of retinal ganglion cells caused by an eye disease in a subject comprising:
(a) providing a photosensitive aza-crown ether or crown ether of a chromene or a diazene compound that releases lithium upon
exposure to light;
(b) administering an effective amount of the aza-crown or crown ether of a chromene or a diazene compound in a pharmaceutically
acceptable carrier to the eye of the subject; and
(c) exposing the eye of the subject to an external light source to cause the aza-crown ether or crown ether of a chromene
or a diazene compound to release lithium wherein the photosensitive aza-crown ether or crown ether moiety of a chromene or
diazene compound has one of the following structures:
wherein Q is a crown ether or an aza-crown ether;
wherein R1, R2, R3, R′1, R′2, and R′3, are the same or different, and are each a phenyl ring or a substituted phenyl ring,
a hydrogen; a halogen, a hydroxyl group, an unsubstituted or substituted lower alkyl, cycloalkyl, aryl, acyl, alkoxy, acylamino,
aralkyl, cyanocarboxyl, thio, vinyl, stryryl, alkoxycarbonyl, carbamoyl, aminocarbonyl, or phenoxycarbonyl; and wherein X1
and X2 are each a phenyl ring or a substituted phenyl ring, an unsubstituted or substituted lower alkyl, cycloalkyl, aryl,
acyl, alkoxyl, aclyamino, aralkyl, cyanocarboxyl, thio, vinyl, stryryl, alkoxycarbonyl, carbamoyl, aminocarbonyl, or phenoxycarbonyl.
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