Castro KG, Metchock BG, McGowan JE, Thompson SE, Curran JW; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 306 (abstract no. Th.C.727).
Centers for Disease Control, Atlanta, Georgia, USA
OBJECTIVE: Determine the prevalence of HIV-associated mycobacterial infections (MI) at GMH, which serves the indigent population of Atlanta. METHODS: Positive mycobacterial cultures from GMH, Jan-Nov 1989 were analyzed by patient's gender, HIV status, organism, specimen source, and compared with 1982. RESULTS: MI occurred in 345 patients. Of these 217 (63%) were M. tuberculosis (TB), a 38% increase from 1982; 116 (34%) had Mycobacteria other than TB (MOTT), a 673% increase from 1982. Twelve (3%) had multiple MIs. HIV status was unknown for 118/345 (34%) patients; these were excluded from subsequent analyses. Of the remaining 227 (66%), 137 (60%) were HIV-positive (HIV+). Compared with HIV-negative (HIV-) patients, HIV+ were more likely to be male (Odds Ratio [OR]=3.7, p less than 0.001), and to have MOTT (OR=17.2, p less than 0.001). There were 139 patients with TB; frequency of pulmonary TB in HIV+ persons (39/56=70%) was similar to that in HIV- (63/83=76%). TB was isolated from multiple sites in 6 patients; this was not significantly influenced by HIV status. Compared with HIV- TB patients, HIV+ were more likely to be male (OR=2.7, p less than 0.03). M. avium complex (MAC) occurred in 68 patients; 65 (96%) were HIV+. CONCLUSIONS: Remarkable increases were documented in both TB and MOTT since 1982, when HIV/AIDS was relatively uncommon at GMH. TB continues to be the most common MI; its clinical site did not differ by HIV status. While less frequent, MAC and mixed MIs mostly occurred in HIV infected patients. HIV+ persons accounted for 40% of culture-positive MIs. Thus, all patients with mycobacterial isolates should be tested for HIV and all HIV+ patients should be evaluated for MI.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Culture
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Mycobacterium
- Mycobacterium Infections
- Mycobacterium avium-intracellulare Infection
- Tuberculosis
- Tuberculosis, Pulmonary
Other ID:
UI: 102182331
From Meeting Abstracts