| Vertebrate Vasopressin Family |
| Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 |
Vasopressin (AVP, ADH, argipressin) |
Most mammals |
| Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 |
Lypressin (LVP) |
Pigs, hippos, warthogs, some marsupials |
| Cys-Phe-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 |
Phenypressin |
Some marsupials |
| Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2 |
Vasotocin |
Non-mammals |
| Vertebrate Oxytocin Family |
| Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 |
Oxytocin (OXT) |
Most mammals, ratfish |
| Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Ile-Gly-NH2 |
Mesotocin |
Most marsupials, all birds, reptiles, amphibians, lungfishes |
| Cys-Tyr-Ile-Ser-Asn-Cys-Pro-Ile-Gly-NH2 |
Isotocin |
Bony fishes |
| Cys-Tyr-Ile-Asn/Gln-Asn-Cys-Pro-Leu/Val-Gly-NH2 |
Various tocins |
Sharks |
| Invertebrate VP/OT Superfamily |
| Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2 |
Diuretic Hormone |
Locust |
| Cys-Phe-Val-Arg-Asn-Cys-Pro-Thr-Gly-NH2 |
Annetocin |
Earthworm |
| Cys-Phe-Ile-Arg-Asn-Cys-Pro-Lys-Gly-NH2 |
Lys-Connopressin |
Geography & imperial cone snail, pond snail, sea hare, leech |
| Cys-Ile-Ile-Arg-Asn-Cys-Pro-Arg-Gly-NH2 |
Arg-Connopressin |
Striped cone snail |
| Cys-Tyr-Phe-Arg-Asn-Cys-Pro-Ile-Gly-NH2 |
Cephalotocin |
Octopus |
| Cys-Phe-Trp-Thr-Ser-Cys-Pro-Ile-Gly-NH2 |
Octopressin |
Octopus |
| Vasotocin is the evolutionary progenitor of all the vertebrate neurohypophysial hormones. Only vasotocin found in hagfish & lampreys (Agnatha appeared 500 million years ago) |