Easterbrook PJ, Smith M, Geretti AM, Osner N, Murad S, Oshea S, Chrystie I, Mullen J, de Ruiter AM, Zuckerman M, HIV Virology Collaborative group GK; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. ThPpC2144.
GKT School of Medicine, London, United Kingdom
BACKGROUND: To compare the rate of disease progression prior to antiretroviral therapy (ART) and the initial response to ART in patients infected with B versus non-B HIV-1 subtypes in an ethnically diverse population of HIV infected patients in South London. METHODS: 900 HIV-1 infected patients from Kings and St. Thomas hospital HIV clinics have been subtyped using an in-house EIA assay. 306 (34%) were infected with a non-B subtype, of which subtypes A and C were the most common. Env gene sequencing is ongoing to confirm the precise distribution of subtypes A, C, and D and various mosaic strains. Rate of disease progression was determined using rate of CD4 cell decline (initial 2 years after diagnosis) stratified according to initial CD4 count (?100, 101-200, 201-400 >400 cells), and pre-treatment viral load profile; response to ART was assessed on time to a viral load ?400 copies/ml. RESULTS: Preliminary analyses were based on 457 patients with complete data. 157 were non-B and 204 were B subtype; 40 were of mixed reactivity and 56 were non-reactive. The majority of non-B subtype found in black African from sub-Saharan Africa (most commonly Uganda, Zimbabwe, Nigeria, Ivory Coast, and Ghana). B subtype patients were mainly Caucasian. 56% of non-B vs. 17% of B subtypes were female. The initial rate of CD4 decline was similar for B and non-B subtypes for each baseline CD4 cell strata. However, after initiation of ART, the % with a VL ?400 copies/ml was higher among B (51.8%) vs. non-B (35.7%) subtype patients, p=0.045. CONCLUSIONS: Based on this preliminary analysis, we found no evidence for B vs. non-B subtype specific differences in disease progression, but non-B subtype patients had a lower initial virological response to antiretroviral therapy.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Africa South of the Sahara
- African Continental Ancestry Group
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Cote d'Ivoire
- Disease Progression
- European Continental Ancestry Group
- Female
- Genes, env
- Ghana
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Immunoenzyme Techniques
- London
- Nigeria
- Uganda
- Viral Load
- Zimbabwe
- genetics
- virology
Other ID:
UI: 102256842
From Meeting Abstracts