BLASTX+BEAUTY Search Results

WU-BLAST 2.0 search of the National Center for Biotechnology Information's NR Protein Database.

BEAUTY post-processing provided by the Human Genome Sequencing Center, Baylor College of Medicine.

BEAUTY Reference:
Worley KC, Culpepper P, Wiese BA, Smith RF. BEAUTY-X: enhanced BLAST searches for DNA queries. Bioinformatics 1998;14(10):890-1. Abstract

Worley KC, Wiese BA, Smith RF. BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results. Genome Res 1995 Sep;5(2):173-84 Abstract

Checking for E. coli insertion elements
Checking for E. coli insertion elements
Masked Sequence:
>'E14B03_D03_04.ab1'
CGGCCGGGGNAGCAGTTATCAAAATCGTGATCTTGAAAAGGCAAACCAGC
AAGCTGCAAAACATCTATATGATGCAAGGGTGCAGCCCAGCACACTAATC
CCAAAGCAAGTTGGTAACATGTACACTGCATCTCTTTATGCAGCATTTGC
ATCTCTTCTTCACAATAAGAACAGTTCGTTGGTAGGTAAACGGGTAGTTA
TGTTTTCATATGGAAGTGGTTTAACAGCTACAATGTTCTCCTTCCAGCTT
CAAGAGGGTCAACATCCGTTTAACTTGTCAAACATTGTAACAGTGATGAA
TGTTTCGGACAAGTTGAAGCAGAGAGTTGAGATTCCTCCTGAAAAGTTCG
TTGAAACATTGAAGATCATGGAACACCGTTATGGGGGTAAGGACTTTGTG
ACAAGCAAGGACTGTAGCTACTTAACTCCAGGCACCTTCTATCTCACCAA
TGTTGATTCCATGTACAGGAGATTTTATGCCAAGAAGGACTAGGTTATTG
GTTAGTTGATGATCGCTGATATATTCAAATATGGAGTTAAAATGTATTTT
CTTATGGTTCACCTGTATTTGATCCCATAAGGTTGTGTATCAAAATGTTT
ATAAGATGTTT


Reference:  Gish, Warren (1994-1997).  unpublished.
Gish, Warren and David J. States (1993).  Identification of protein coding
regions by database similarity search.  Nat. Genet. 3:266-72.

Notice:  statistical significance is estimated under the assumption that the
equivalent of one entire reading frame in the query sequence codes for protein
and that significant alignments will involve only coding reading frames.

Query=  'E14B03_D03_04.ab1'
        (611 letters)
  Translating both strands of query sequence in all 6 reading frames

Database:  nr
           625,274 sequences; 197,782,623 total letters.


     Observed Numbers of Database Sequences Satisfying
    Various EXPECTation Thresholds (E parameter values)

        Histogram units:      = 3 Sequences     : less than 3 sequences

 EXPECTation Threshold
 (E parameter)
    |
    V   Observed Counts-->
  10000 641 143 |===============================================
   6310 498  96 |================================
   3980 402  83 |===========================
   2510 319  78 |==========================
   1580 241  90 |==============================
   1000 151  36 |============
    631 115  36 |============
    398  79   8 |==
    251  71   8 |==
    158  63   7 |==
    100  56   1 |:
   63.1  55   2 |:
   39.8  53   2 |:
   25.1  51   2 |:
   15.8  49   0 |
 >>>>>>>>>>>>>>>>>>>>>  Expect = 10.0, Observed = 49  <<<<<<<<<<<<<<<<<
   10.0  49   0 |
   6.31  49   1 |:
   3.98  48   0 |
   2.51  48   0 |
   1.58  48   0 |
   1.00  48   0 |
   0.63  48   0 |
   0.40  48   1 |:
   0.25  47   1 |:
   0.16  46   0 |
   0.10  46   0 |
  0.063  46   0 |
  0.040  46   0 |
  0.025  46   0 |
  0.016  46   0 |
  0.010  46   0 |
 0.0063  46   2 |:
 0.0040  44   1 |:


                                                                     Smallest
                                                                       Sum
                                                     Reading  High  Probability
Sequences producing High-scoring Segment Pairs:        Frame Score  P(N)      N
gi|7799986|gb|AAF69804.1|AF148847_1(AF148847) HMG-CoA... +2   587  4.7e-56   1
gi|11192003|gb|AAG32922.1|AF188639_1(AF188639) HMG-Co... +2   582  1.6e-55   1
gi|11192005|gb|AAG32923.1|AF188640_1(AF188640) HMG-Co... +2   582  1.6e-55   1
gi|1708236|sp|P54873|HMCS_ARATHHYDROXYMETHYLGLUTARYL-... +2   575  8.8e-55   1
gi|7436679|pir||T09341hydroxymethylglutaryl-CoA synth... +2   572  1.8e-54   1
gi|11192007|gb|AAG32924.1|AF188641_1(AF188641) HMG-Co... +2   552  2.4e-52   1
gi|7436678|pir||T09688hydroxymethylglutaryl-CoA synth... +2   549  5.0e-52   1
gi|1708232|sp|P54961|HMC1_BLAGEHYDROXYMETHYLGLUTARYL-... +2   301  1.3e-25   1
gi|1708233|sp|P54870|HMC2_BLAGEHYDROXYMETHYLGLUTARYL-... +2   287  5.6e-24   1
gi|1708238|sp|P54872|HMCS_DICDIHYDROXYMETHYLGLUTARYL-... +2   280  1.6e-23   1
gi|3913867|sp|O02734|HMCM_PIGHYDROXYMETHYLGLUTARYL-CO... +2   285  1.7e-23   1
gi|555833|gb|AAA92674.1|(U12789) HMG CoA synthase [Ho... +2   276  4.2e-23   1
gi|123330|sp|P22791|HMCM_RATHYDROXYMETHYLGLUTARYL-COA... +2   278  1.0e-22   1
gi|1083370|pir||B55729hydroxymethylglutaryl-CoA synth... +2   276  1.2e-22   1
gi|1708235|sp|P54869|HMCM_MOUSEHYDROXYMETHYLGLUTARYL-... +2   276  1.3e-22   1
gi|5031751ref|NP_005509.1| 3-hydroxy-3-methylglutaryl... +2   276  1.7e-22   1
gi|11602786|emb|CAC18553.1|(AJ297414) putative 3-hydr... +2   273  2.1e-22   1
gi|11416914ref|XP_003856.1| 3-hydroxy-3-methylglutary... +2   264  7.9e-22   1
gi|12731376ref|XP_011295.1| 3-hydroxy-3-methylglutary... +2   264  7.9e-22   1
gi|6323509ref|NP_013580.1| 3-hydroxy-3-methylglutaryl... +2   268  1.1e-21   1
gi|123332|sp|P13704|HMCS_CRIGRHYDROXYMETHYLGLUTARYL-C... +2   264  3.8e-21   1
gi|4504429ref|NP_002121.1| 3-hydroxy-3-methylglutaryl... +2   264  3.8e-21   1
gi|8393538ref|NP_058964.1| 3-hydroxy-3-methylglutaryl... +2   262  6.3e-21   1
gi|7302938|gb|AAF58009.1|(AE003807) CG4311 gene produ... +2   260  7.1e-21   1
gi|284048|pir||S27197hydroxymethylglutaryl-CoA syntha... +2   255  3.7e-20   1
gi|9621905|gb|AAF89580.1|AF166002_1(AF166002) 3-hydro... +2   251  6.6e-20   1
gi|86312|pir||S13887hydroxymethylglutaryl-CoA synthas... +2   250  1.3e-19   1
gi|123331|sp|P23228|HMCS_CHICKHYDROXYMETHYLGLUTARYL-C... +2   250  1.3e-19   1
gi|555837|gb|AAA92676.1|(U12791) HMG CoA synthase [Mu... +2   239  3.5e-19   1
gi|1708240|sp|P54874|HMCS_SCHPOHYDROXYMETHYLGLUTARYL-... +2   234  4.6e-18   1
gi|11268273|pir||T49718probable hydroxymethylglutaryl... +2   233  6.3e-18   1
gi|555835|gb|AAA92675.1|(U12790) HMG CoA synthase [Mu... +2   195  8.1e-14   1
gi|1708237|sp|P54871|HMCS_CAEELHYDROXYMETHYLGLUTARYL-... +2   186  9.0e-13   1
gi|7499787|pir||T25726hypothetical protein F25B4.6 - ... +2   186  9.1e-13   1
gi|10581089|gb|AAG19877.1|(AE005072) 3-hydroxy-3-meth... +2   145  1.4e-07   1
gi|9937404|gb|AAG02453.1|AF290098_1(AF290098) HMG-CoA... +2   144  1.7e-07   1
gi|9937397|gb|AAG02448.1|AF290096_1(AF290096) HMG-CoA... +2   139  1.2e-06   1
gi|12724576|gb|AAK05670.1|AE006388_1(AE006388) hydrox... +2   135  4.5e-06   1
gi|9937390|gb|AAG02443.1|AF290094_1(AF290094) HMG-CoA... +2   133  8.1e-06   1
gi|9937383|gb|AAG02438.1|AF290092_1(AF290092) HMG-CoA... +2   130  2.0e-05   1
gi|11356423|pir||T44125hypothetical protein [imported... +2   104  0.00013   1
gi|9937368|gb|AAG02427.1|AF290088_1(AF290088) HMG-CoA... +2   121  0.00029   1
gi|9937361|gb|AAG02422.1|AF290086_1(AF290086) HMG-CoA... +2   120  0.00039   1
gi|9937376|gb|AAG02433.1|AF290090_1(AF290090) HMG-CoA... +2   112  0.0036    1
gi|5419956|emb|CAB46505.1|(AJ132503) TaF protein [Myx... +2   110  0.0059    1
gi|4096796|gb|AAD10460.1|(U40157) orf1; unknown funct... +2   110  0.0062    1
gi|9711351|dbj|BAB07822.1|(AB037907) HMG-CoA synthase... +2    97  0.16      1
gi|9695275|dbj|BAB07795.1|(AB037666) 3-hydroxy-3-meth... +2    95  0.31      1
gi|730331|sp|P40830|PKSG_BACSUPUTATIVE POLYKETIDE BIO... +2    84  0.997     1

Use the  and  icons to retrieve links to Entrez:
E = Retrieve Entrez links (e.g., Medline abstracts, FASTA-formatted sequence reports).
R = Retrieve links to Related sequences (neighbors).

Use the  icon (if present) to retrieve links to the Sequence Retrieval System (SRS).

Use the  icon (if present) to retrieve links to the Ligand Enzyme and Chemical Compound Database .

Use the  icon (if present) to retrieve links to the Protein Data Bank database.


 >gi|7799986|gb|AAF69804.1|AF148847_1  (AF148847) HMG-CoA synthase [Brassica
            juncea]
            Length = 461

Frame  2 hits (HSPs):                                  __________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 461
                       0              150             300             450

  Plus Strand HSPs:

 Score = 587 (206.6 bits), Expect = 4.7e-56, P = 4.7e-56
 Identities = 115/160 (71%), Positives = 132/160 (82%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ AK  YDA+VQP+TL+PKQVGNMYTASLYAAFASL+HNK+S L GKR
Sbjct:   292 SYQSRDLEKVSQQLAKTYYDAKVQPTTLVPKQVGNMYTASLYAAFASLVHNKHSDLAGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L E Q PF+LSNI +VM+V  KLK R E  PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLCENQSPFSLSNIASVMDVGGKLKARHEYAPEKFVETMKLME 411

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG K+FVTSK+     L PGT+YL  VDS+YRRFY KK
Sbjct:   412 HRYGAKEFVTSKEGILDLLAPGTYYLKEVDSLYRRFYGKK 451


 >gi|11192003|gb|AAG32922.1|AF188639_1  (AF188639) HMG-CoA synthase [Brassica
            juncea]
            Length = 461

Frame  2 hits (HSPs):                                  __________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 461
                       0              150             300             450

  Plus Strand HSPs:

 Score = 582 (204.9 bits), Expect = 1.6e-55, P = 1.6e-55
 Identities = 112/160 (70%), Positives = 132/160 (82%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ AK  YDA+VQP+TL+PK+VGNMYTASLYAAFASL+HN++S L GKR
Sbjct:   292 SYQSRDLEKVSQQVAKTFYDAKVQPTTLVPKEVGNMYTASLYAAFASLIHNEHSDLAGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L E Q PF+LSNI +VM++  KLK R E  PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLCENQSPFSLSNIASVMDIGGKLKARHEYAPEKFVETMKLME 411

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG K+FVTSK+     L PGT+YL  VDS+YRRFY KK
Sbjct:   412 HRYGAKEFVTSKEGILELLAPGTYYLKEVDSLYRRFYGKK 451


 >gi|11192005|gb|AAG32923.1|AF188640_1  (AF188640) HMG-CoA synthase [Brassica
            juncea]
            Length = 461

Frame  2 hits (HSPs):                                  __________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 461
                       0              150             300             450

  Plus Strand HSPs:

 Score = 582 (204.9 bits), Expect = 1.6e-55, P = 1.6e-55
 Identities = 112/160 (70%), Positives = 131/160 (81%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ AK  YD +VQP+TL+PK+VGNMYTASLYAAFASL+HNK+S L GKR
Sbjct:   292 SYQSRDLEKVSQQVAKTFYDGKVQPTTLVPKEVGNMYTASLYAAFASLIHNKHSDLAGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L E + PF+LSNI +VM++  KLK R E  PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLCENKSPFSLSNIASVMDIGGKLKARHEYAPEKFVETMKLME 411

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG KDFVTSK+     L PGT+YL  VDS+YRRFY KK
Sbjct:   412 HRYGAKDFVTSKEGILELLAPGTYYLKEVDSLYRRFYGKK 451


 >gi|1708236|sp|P54873|HMCS_ARATH  HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA
            SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|2129617|pir||JC4567 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - Arabidopsis thaliana >gi|1143390|emb|CAA58763.1|
            (X83882) hydroxymethylglutaryl-CoA synthase [Arabidopsis thaliana]
            >gi|1586548|prf||2204245A hydroxy methylglutaryl CoA synthase
            [Arabidopsis thaliana]
            Length = 461

Frame  2 hits (HSPs):                                  __________________ 
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 461
                       0              150             300             450
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 1..39
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 46..77
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 78..117
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 125..160
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 163..203
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 204..221
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 238..266
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 331..378
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 405..452
   DOMO                 DM01933:                                 1..450
   Entrez               active site: POTENTIAL.                  117
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 1..451
   PRODOM               PD005059: HMCS(7) HMCM(3)                3..48
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     53..179
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        186..248
   PRODOM               PD004407: HMCS(7) HMCM(3)                250..446
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 105..120
__________________


  Plus Strand HSPs:

 Score = 575 (202.4 bits), Expect = 8.8e-55, P = 8.8e-55
 Identities = 110/160 (68%), Positives = 132/160 (82%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ +K  YDA+VQP+TLIPK+VGNMYTASLYAAFASL+HNK++ L GKR
Sbjct:   292 SYQSRDLEKVSQQISKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHNKHNDLAGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L + + PF++SNI +VM+V  KLK R E  PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLNDNKPPFSISNIASVMDVGGKLKARHEYAPEKFVETMKLME 411

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG KDFVT+K+     L PGT+YL  VDS+YRRFY KK
Sbjct:   412 HRYGAKDFVTTKEGIIDLLAPGTYYLKEVDSLYRRFYGKK 451


 >gi|7436679|pir||T09341  hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) -
            Arabidopsis thaliana >gi|4098521|gb|AAD00297.1| (U79160) HMG-CoA
            synthase [Arabidopsis thaliana] >gi|4098523|gb|AAD00298.1| (U79161)
            HMG-CoA synthase [Arabidopsis thaliana] >gi|5002517|emb|CAB44320.1|
            (AL078606) hydroxymethylglutaryl-CoA synthase [Arabidopsis
            thaliana] >gi|7267882|emb|CAB78225.1| (AL161532)
            hydroxymethylglutaryl-CoA synthase [Arabidopsis thaliana]
            Length = 461

Frame  2 hits (HSPs):                                  __________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 461
                       0              150             300             450

  Plus Strand HSPs:

 Score = 572 (201.4 bits), Expect = 1.8e-54, P = 1.8e-54
 Identities = 110/160 (68%), Positives = 131/160 (81%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ AK  YDA+VQP+TLIPK+VGNMYTASLYAAFASL+H K++ L GKR
Sbjct:   292 SYQSRDLEKVSQQIAKPFYDAKVQPTTLIPKEVGNMYTASLYAAFASLIHKKHNDLAGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L + + PF++SNI +VM+V  KLK R E  PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLNDNKPPFSISNIASVMDVGGKLKARHEYAPEKFVETMKLME 411

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG KDFVT+K+     L PGT+YL  VDS+YRRFY KK
Sbjct:   412 HRYGAKDFVTTKEGIIDLLAPGTYYLKEVDSLYRRFYGKK 451


 >gi|11192007|gb|AAG32924.1|AF188641_1  (AF188641) HMG-CoA synthase [Brassica
            juncea]
            Length = 453

Frame  2 hits (HSPs):                                   _________________ 
                        __________________________________________________
Database sequence:     |                |                |               || 453
                       0              150              300             450

  Plus Strand HSPs:

 Score = 552 (194.3 bits), Expect = 2.4e-52, P = 2.4e-52
 Identities = 110/158 (69%), Positives = 129/158 (81%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SYQ+RDLEK +QQ AK  YDA+VQP+TL+PKQVGNMYTASLYAAFASL+HNK++ LVGKR
Sbjct:   292 SYQSRDLEKVSQQLAKTFYDAKVQPTTLVPKQVGNMYTASLYAAFASLIHNKHNDLVGKR 351

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             VVMFSYGSG TATMFS +L E Q PF+LSNI +VM+V         + PEKFVET+K+ME
Sbjct:   352 VVMFSYGSGSTATMFSLRLCENQSPFSLSNIASVMDVG--------VSPEKFVETMKLME 403

Query:   374 HRYGGKDFVTSKD--CSYLTPGTFYLTNVDSMYRRFYAKK 487
             HRYG K+FVTSK+     L PGT+YL  VDS+YRRFY KK
Sbjct:   404 HRYGAKEFVTSKEGILDLLAPGTYYLKEVDSLYRRFYGKK 443


 >gi|7436678|pir||T09688  hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5),
            ozone-inducible - Scotch pine >gi|1655679|emb|CAA65250.1| (X96386)
            3-hydroxy-3-methylglutaryl-CoA-synthase [Pinus sylvestris]
            Length = 474

Frame  2 hits (HSPs):                                  _________________  
                        __________________________________________________
Database sequence:     |               |               |               |  | 474
                       0             150             300             450

  Plus Strand HSPs:

 Score = 549 (193.3 bits), Expect = 5.0e-52, P = 5.0e-52
 Identities = 105/158 (66%), Positives = 128/158 (81%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKR 193
             SY +RDLEK +QQ AK LYDA++QPSTL+PKQVGNMYTASLYAA AS++HNK+++L G+R
Sbjct:   295 SYNSRDLEKVSQQLAKPLYDAKIQPSTLLPKQVGNMYTASLYAALASIIHNKHTTLDGQR 354

Query:   194 VVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             V+MFSYGSGL +T+FSF+++EGQ PF LSNI  VM+V +KL  R E  PE FVE LK ME
Sbjct:   355 VMMFSYGSGLASTLFSFKIREGQFPFTLSNITEVMDVQNKLDSRHEFLPEDFVENLKRME 414

Query:   374 HRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
               YG KDFV++   S L PG FYLT VDSMYRRFY++K
Sbjct:   415 TLYGAKDFVSTSQLSLLRPGAFYLTKVDSMYRRFYSRK 452


 >gi|1708232|sp|P54961|HMC1_BLAGE  HYDROXYMETHYLGLUTARYL-COA SYNTHASE 1 (HMG-COA
            SYNTHASE 1) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE 1)
            >gi|630819|pir||S38986 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - German cockroach >gi|1772495|emb|CAA52032.1| (X73679)
            hydroxymethylglutaryl-CoA synthase [Blattella germanica]
            Length = 453

Frame  2 hits (HSPs):                                   __________________
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                |                |               || 453
                       0              150              300             450
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 2..40
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 47..78
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 79..118
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 124..159
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 162..202
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 203..220
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 237..265
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 331..378
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 405..452
   DOMO                 DM01933:                                 2..450
   Entrez               active site: POTENTIAL.                  116
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 2..451
   PRODOM               PD005059: HMCS(7) HMCM(3)                2..49
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     51..169
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        185..247
   PRODOM               PD004407: HMCS(7) HMCM(3)                249..450
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 104..119
   PROSITE              LEUCINE_ZIPPER: Leucine zipper pattern.  347..368
__________________


  Plus Strand HSPs:

 Score = 301 (106.0 bits), Expect = 1.3e-25, P = 1.3e-25
 Identities = 61/158 (38%), Positives = 100/158 (63%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             +Y +R++EKA    +K++++ + +PS L+  QVGNMYT SLY    SLL +K++  L GK
Sbjct:   291 TYFDREVEKAVMTYSKNMFEEKTKPSLLLANQVGNMYTPSLYGGLVSLLVSKSAQELAGK 350

Query:   191 RVVMFSYGSGLTATMFSFQLQ-EGQHPFNLSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             RV +FSYGSGL ++MFS ++  +     +L  +V+ + ++  +L  R ++ PE+F +T++
Sbjct:   351 RVALFSYGSGLASSMFSLRISSDASAKSSLQRLVSNLSHIKPQLDLRHKVSPEEFAQTME 410

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFY 478
               EH +    +        L PGT+YL +VDS+YRR Y
Sbjct:   411 TREHNHHKAPYTPEGSIDVLFPGTWYLESVDSLYRRSY 448


 >gi|1708233|sp|P54870|HMC2_BLAGE  HYDROXYMETHYLGLUTARYL-COA SYNTHASE 2 (HMG-COA
            SYNTHASE 2) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE 2)
            >gi|627145|pir||A53565 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - German cockroach >gi|488134|emb|CAA54652.1| (X77516)
            hydroxymethylglutaryl-CoA synthase [Blattella germanica]
            Length = 455

Frame  2 hits (HSPs):                                   __________________
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                |               |                || 455
                       0              150             300              450
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 4..42
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 49..80
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 81..120
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 128..163
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 165..205
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 206..223
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 246..274
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 335..382
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 409..456
   DOMO                 DM01933:                                 4..454
   Entrez               active site: POTENTIAL.                  120
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 4..455
   PRODOM               PD005059: HMCS(7) HMCM(3)                4..51
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     53..151
   PRODOM               PD209712: HMC2_BLAGE                     153..186
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        188..256
   PRODOM               PD004407: HMCS(7) HMCM(3)                258..454
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 108..123
__________________


  Plus Strand HSPs:

 Score = 287 (101.0 bits), Expect = 5.6e-24, P = 5.6e-24
 Identities = 60/160 (37%), Positives = 97/160 (60%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EK     +K L++ + +PS ++  QVGNMYT SLY    SLL +++   L GK
Sbjct:   295 TYFDRDIEKIFMDKSKQLFEKKTKPSLMLANQVGNMYTTSLYGGLVSLLISEDIGELAGK 354

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
              + MFSYGSG  A+MFS  +     P + LS +VT + ++  +++QRV++ P +F   ++
Sbjct:   355 CICMFSYGSGFAASMFSLHISTDSSPGSTLSRLVTNLTHIKPQVQQRVKLSPGEFENIME 414

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAK 484
             I E  +    +      + L PGT+YL ++DSM+RR Y +
Sbjct:   415 IREQNHHKAPYTPVASPNTLFPGTWYLESIDSMHRRKYKR 454


 >gi|1708238|sp|P54872|HMCS_DICDI  HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA
            SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|1209283|gb|AAA91055.1| (L24114) hydroxymethylglutaryl-CoA
            synthase [Dictyostelium discoideum]
            Length = 163

Frame  2 hits (HSPs):    _________________________________________        
Annotated Domains:      ___________________________________________       
                        __________________________________________________
Database sequence:     |               |              |              |    | 163
                       0              50            100            150
__________________

Annotated Domains:
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 2..140
__________________


  Plus Strand HSPs:

 Score = 280 (98.6 bits), Expect = 1.6e-23, P = 1.6e-23
 Identities = 59/136 (43%), Positives = 91/136 (66%), Frame = +2

Query:    68 YDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQ 247
             Y  +V P+TL+ KQ+GN Y  S Y+   SLL  K++ LVGKRV+ FSYGSGL A+ FSF+
Sbjct:     6 YATKVAPTTLLAKQLGNTYCGSTYSGLLSLLDEKSNDLVGKRVLTFSYGSGLAASAFSFK 65

Query:   248 LQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLT 427
             +++   P N  +IV  +++ ++L +RV + PE F E L + E R+  K++V S + + + 
Sbjct:    66 VEK---PIN--HIVEKVDLKNRLAKRVRVEPEIFTEKLSLRETRHNLKNYVPSDETTNMF 120

Query:   428 PGTFYLTNVDSM-YRRF 475
             PG+FYL++VD    R+F
Sbjct:   121 PGSFYLSSVDKAGIRKF 137


 >gi|3913867|sp|O02734|HMCM_PIG  HYDROXYMETHYLGLUTARYL-COA SYNTHASE,
            MITOCHONDRIAL PRECURSOR (HMG-COA SYNTHASE)
            (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|2058658|gb|AAC48727.1| (U90884) hydroxymethylglutaryl-CoA
            synthase [Sus scrofa]
            Length = 508

Frame  2 hits (HSPs):                                    _________________
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |              |              |              |     | 508
                       0            150            300            450
__________________

Annotated Domains:
   Entrez               active site: POTENTIAL.                  166
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 50..506
   PRODOM               PD024710: HMCM(3)                        1..48
   PRODOM               PD005059: HMCS(7) HMCM(3)                50..96
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     104..229
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        235..302
   PRODOM               PD004407: HMCS(7) HMCM(3)                306..500
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 154..169
__________________


  Plus Strand HSPs:

 Score = 285 (100.3 bits), Expect = 1.7e-23, P = 1.7e-23
 Identities = 62/160 (38%), Positives = 96/160 (60%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             +Y N+D+EKA Q+A+  L++ + +PS  +    GNMYT+SLY   ASLL   ++  L G 
Sbjct:   346 TYANKDIEKAFQKASLDLFNKKTKPSLYLSLHNGNMYTSSLYGCLASLLSQCSAQDLAGS 405

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ +S ++ +   P + L  +V+ V ++ ++L  R  + PE+F E + 
Sbjct:   406 RIGAFSYGSGLAASFYSLRVSQDASPGSPLEKLVSSVSDLPERLASRKRVSPEEFTEIMN 465

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAK 484
               E  Y   +F    D + L PGT+YL  VD +YRR YA+
Sbjct:   466 QREQYYHKVNFTPPGDPNSLFPGTWYLERVDELYRRKYAR 505


 >gi|555833|gb|AAA92674.1|  (U12789) HMG CoA synthase [Homo sapiens]
            Length = 363

Frame  2 hits (HSPs):                              _______________________
                        __________________________________________________
Database sequence:     |                    |                    |        | 363
                       0                  150                  300

  Plus Strand HSPs:

 Score = 276 (97.2 bits), Expect = 4.2e-23, P = 4.2e-23
 Identities = 61/161 (37%), Positives = 94/161 (58%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+DL+KA  +A++ ++D + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   201 TYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGS 260

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ FSF++ +   P + L  +V+   ++  +L  R  + PE+F E + 
Sbjct:   261 RIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMN 320

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
               E  Y   +F    D + L PGT+YL  VD  +RR YA++
Sbjct:   321 QREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 361


 >gi|123330|sp|P22791|HMCM_RAT  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL
            PRECURSOR (HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A
            SYNTHASE) >gi|111794|pir||A35865 hydroxymethylglutaryl-CoA synthase
            (EC 4.1.3.5) precursor - rat >gi|204619|gb|AAA41336.1| (M33648)
            3-hydroxy-3-methylglutaryl-CoA synthase precursor (EC 4.1.3.5)
            [Rattus norvegicus]
            Length = 508

Frame  2 hits (HSPs):                                    _________________
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |              |              |              |     | 508
                       0            150            300            450
__________________

Annotated Domains:
   Entrez               active site: POTENTIAL.                  166
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 50..506
   PRODOM               PD024710: HMCM(3)                        1..48
   PRODOM               PD005059: HMCS(7) HMCM(3)                50..96
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     104..218
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        235..302
   PRODOM               PD004407: HMCS(7) HMCM(3)                306..500
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 154..169
__________________


  Plus Strand HSPs:

 Score = 278 (97.9 bits), Expect = 1.0e-22, P = 1.0e-22
 Identities = 62/161 (38%), Positives = 95/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+D++KA  +A+  +++ + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   346 TYTNKDVDKALLKASLDMFNKKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGS 405

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ FSF++ +   P + L  +V+ V ++  +L  R  + PE+F E + 
Sbjct:   406 RIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMN 465

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
               E  Y   +F    D S L PGT+YL  VD M+RR YA++
Sbjct:   466 QREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYARR 506


 >gi|1083370|pir||B55729  hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5),
            mitochondrial - mouse
            Length = 471

Frame  2 hits (HSPs):                                   __________________
Annotated Domains:                  __                                    
                        __________________________________________________
Database sequence:     |               |               |               |  | 471
                       0             150             300             450
__________________

Annotated Domains:
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 117..132
__________________


  Plus Strand HSPs:

 Score = 276 (97.2 bits), Expect = 1.2e-22, P = 1.2e-22
 Identities = 62/160 (38%), Positives = 94/160 (58%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+D++KA  +A+  +++ + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   309 TYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGS 368

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ FSF++ +   P + L  +V+ V ++  +L  R  + PE+F E + 
Sbjct:   369 RIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMN 428

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAK 484
               E  Y   +F    D S L PGT+YL  VD M+RR YA+
Sbjct:   429 QREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYAR 468


 >gi|1708235|sp|P54869|HMCM_MOUSE  HYDROXYMETHYLGLUTARYL-COA SYNTHASE,
            MITOCHONDRIAL PRECURSOR (HMG-COA SYNTHASE)
            (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            Length = 480

Frame  2 hits (HSPs):                                    _________________
Annotated Domains:        ________________________________________________
                        __________________________________________________
Database sequence:     |               |               |              |   | 480
                       0             150             300            450
__________________

Annotated Domains:
   Entrez               active site: POTENTIAL.                  138
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 22..478
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 126..141
__________________


  Plus Strand HSPs:

 Score = 276 (97.2 bits), Expect = 1.3e-22, P = 1.3e-22
 Identities = 62/160 (38%), Positives = 94/160 (58%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+D++KA  +A+  +++ + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   318 TYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGS 377

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ FSF++ +   P + L  +V+ V ++  +L  R  + PE+F E + 
Sbjct:   378 RIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEFTEIMN 437

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAK 484
               E  Y   +F    D S L PGT+YL  VD M+RR YA+
Sbjct:   438 QREQFYHKVNFSPPGDTSNLFPGTWYLERVDEMHRRKYAR 477


 >gi|5031751  ref|NP_005509.1| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
            (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
            [Homo sapiens] >gi|11422413 ref|XP_001425.1|
            3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
            [Homo sapiens] >gi|1708234|sp|P54868|HMCM_HUMAN
            HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL PRECURSOR
            (HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|1082474|pir||S51103 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) precursor, mitochondrial - human >gi|7436676|pir||S71623
            hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) precursor,
            mitochondrial - human >gi|619877|emb|CAA58593.1| (X83618)
            hydroxymethylglutaryl-CoA synthase [Homo sapiens]
            >gi|2463646|gb|AAB72036.1| (U81860) 3-hydroxy-3-methylglutaryl CoA
            synthase [Homo sapiens]
            Length = 508

Frame  2 hits (HSPs):                                    _________________
                        __________________________________________________
Database sequence:     |              |              |              |     | 508
                       0            150            300            450

  Plus Strand HSPs:

 Score = 276 (97.2 bits), Expect = 1.7e-22, P = 1.7e-22
 Identities = 61/161 (37%), Positives = 94/161 (58%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+DL+KA  +A++ ++D + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   346 TYTNKDLDKALLKASQDMFDKKTKASLYLSTHNGNMYTSSLYGCLASLLSHHSAQELAGS 405

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKFVETLK 364
             R+  FSYGSGL A+ FSF++ +   P + L  +V+   ++  +L  R  + PE+F E + 
Sbjct:   406 RIGAFSYGSGLAASFFSFRVSQDAAPGSPLDKLVSSTSDLPKRLASRKCVSPEEFTEIMN 465

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
               E  Y   +F    D + L PGT+YL  VD  +RR YA++
Sbjct:   466 QREQFYHKVNFSPPGDTNSLFPGTWYLERVDEQHRRKYARR 506


 >gi|11602786|emb|CAC18553.1|  (AJ297414) putative 3-hydroxy-3-methylglutaryl
            coenzyme A synthase [Phycomyces blakesleeanus]
            Length = 450

Frame  2 hits (HSPs):                                   __________________
                        __________________________________________________
Database sequence:     |                |                |                | 450
                       0              150              300

  Plus Strand HSPs:

 Score = 273 (96.1 bits), Expect = 2.1e-22, P = 2.1e-22
 Identities = 58/160 (36%), Positives = 93/160 (58%), Frame = +2

Query:    11 SSYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVG 187
             +S +NRDLEKA     K  Y  +V P+   PKQ+GNMY  +++A  ASL+      +L  
Sbjct:   295 ASLENRDLEKATATLTKAGYAQKVGPAAYAPKQIGNMYAGAVWAGLASLVSEVEVDTLKD 354

Query:   188 KRVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKI 367
             KRV+++SYGSGL A+M SF++  G    + ++I   +N+  +L  R    PE F E ++I
Sbjct:   355 KRVLLYSYGSGLAASMVSFRVV-G----STADIKAKLNLRQRLDARTHSKPEAFAEAMQI 409

Query:   368 MEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKKD 490
              E+ +   ++       ++ PG +Y+  +D  +RRFY +KD
Sbjct:   410 RENTHNACNYNPIGSLEHIAPGAYYVDKIDDKWRRFYKRKD 450


 >gi|11416914  ref|XP_003856.1| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            (soluble) [Homo sapiens]
            Length = 348

Frame  2 hits (HSPs):                      ________________________       
                        __________________________________________________
Database sequence:     |                     |                    |       | 348
                       0                   150                  300

  Plus Strand HSPs:

 Score = 264 (92.9 bits), Expect = 7.9e-22, P = 7.9e-22
 Identities = 55/161 (34%), Positives = 95/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EKA  +A+  L+  + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   137 TYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGK 196

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + +T  + ++  +L  R  + P+ F E +K
Sbjct:   197 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMK 256

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   257 LREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 297


 >gi|12731376  ref|XP_011295.1| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            (soluble) [Homo sapiens]
            Length = 357

Frame  2 hits (HSPs):                       _______________________       
                        __________________________________________________
Database sequence:     |                    |                    |        | 357
                       0                  150                  300

  Plus Strand HSPs:

 Score = 264 (92.9 bits), Expect = 7.9e-22, P = 7.9e-22
 Identities = 55/161 (34%), Positives = 95/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EKA  +A+  L+  + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   146 TYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGK 205

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + +T  + ++  +L  R  + P+ F E +K
Sbjct:   206 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMK 265

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   266 LREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 306


 >gi|6323509  ref|NP_013580.1| 3-hydroxy-3-methylglutaryl coenzyme A synthase;
            Erg13p [Saccharomyces cerevisiae] >gi|1708241|sp|P54839|HMCS_YEAST
            HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA SYNTHASE)
            (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|2131285|pir||S58202 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - yeast  (Saccharomyces cerevisiae)
            >gi|927536|emb|CAA90557.1| (Z50178) unknown [Saccharomyces
            cerevisiae] >gi|1304355|emb|CAA65437.1| (X96617)
            3-hydroxy-3-methylglutaryl coenzyme A synthase [Saccharomyces
            cerevisiae]
            Length = 491

Frame  2 hits (HSPs):                                     ________________
                        __________________________________________________
Database sequence:     |               |              |              |    | 491
                       0             150            300            450

  Plus Strand HSPs:

 Score = 268 (94.3 bits), Expect = 1.1e-21, P = 1.1e-21
 Identities = 59/158 (37%), Positives = 97/158 (61%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             S  ++++EK     AK  +  RV  S ++P   GNMYTAS+YAAFASLL+   S  L GK
Sbjct:   337 SLTDKNIEKTFVNVAKPFHKERVAQSLIVPTNTGNMYTASVYAAFASLLNYVGSDDLQGK 396

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIM 370
             RV +FSYGSGL A+++S ++  G    ++ +I+  +++++KL +R+   P+ +   +++ 
Sbjct:   397 RVGLFSYGSGLAASLYSCKIV-G----DVQHIIKELDITNKLAKRITETPKDYEAAIELR 451

Query:   371 EHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             E+ +  K+F       +L  G +YLTN+D  +RR Y  K
Sbjct:   452 ENAHLKKNFKPQGSIEHLQSGVYYLTNIDDKFRRSYDVK 490


 >gi|123332|sp|P13704|HMCS_CRIGR  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
            (HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|90200|pir||A25332 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - Chinese hamster >gi|387072|gb|AAA37076.1| (L00334)
            3-hydroxy-3-methylglutaryl coenzyme A synthase (HMG CoA)
            [Mesocricetus auratus]
            Length = 520

Frame  2 hits (HSPs):                                _________________    
Annotated Domains:       _________________________________________________
                        __________________________________________________
Database sequence:     |              |             |              |      | 520
                       0            150           300            450
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 13..51
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 58..89
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 90..129
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 137..172
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 175..215
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 216..233
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 255..283
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 349..396
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 423..470
   Entrez               active site: POTENTIAL.                  129
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 13..469
   PRODOM               PD005059: HMCS(7) HMCM(3)                13..60
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     62..185
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        198..260
   PRODOM               PD004407: HMCS(7) HMCM(3)                262..463
   PRODOM               PD017985: HMCS(4)                        465..519
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 117..132
__________________


  Plus Strand HSPs:

 Score = 264 (92.9 bits), Expect = 3.8e-21, P = 3.8e-21
 Identities = 56/161 (34%), Positives = 96/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EKA  +A+  L++ + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   309 TYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGK 368

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + VT  + ++  +L  R  + P+ F E +K
Sbjct:   369 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKVTASLCDLKSRLDSRTCVAPDVFAENMK 428

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   429 LREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARR 469


 >gi|4504429  ref|NP_002121.1| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 [Homo
            sapiens] >gi|1708239|sp|Q01581|HMCS_HUMAN HYDROXYMETHYLGLUTARYL-COA
            SYNTHASE, CYTOPLASMIC (HMG-COA SYNTHASE)
            (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|7436677|pir||S45497 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5), cytosolic, adrenal isoform - human
            >gi|410028|gb|AAA62411.1| (L25798) 3-hydroxy-3-methylglutaryl
            coenzyme A synthase [Homo sapiens]
            >gi|12653065|gb|AAH00297.1|AAH00297 (BC000297)
            3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) [Homo
            sapiens]
            Length = 520

Frame  2 hits (HSPs):                                _________________    
                        __________________________________________________
Database sequence:     |              |             |              |      | 520
                       0            150           300            450

  Plus Strand HSPs:

 Score = 264 (92.9 bits), Expect = 3.8e-21, P = 3.8e-21
 Identities = 55/161 (34%), Positives = 95/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EKA  +A+  L+  + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   309 TYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGK 368

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + +T  + ++  +L  R  + P+ F E +K
Sbjct:   369 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMK 428

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   429 LREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469


 >gi|8393538  ref|NP_058964.1| 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
            [Rattus norvegicus] >gi|123333|sp|P17425|HMCS_RAT
            HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC (HMG-COA SYNTHASE)
            (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|111795|pir||S12736 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5), cytosolic - rat >gi|55947|emb|CAA36852.1| (X52625)
            cytosolic 3-hydroxy 3-methylglutaryl coenzyme A synthase (AA 1-520)
            [Rattus norvegicus]
            Length = 520

Frame  2 hits (HSPs):                                _________________    
                        __________________________________________________
Database sequence:     |              |             |              |      | 520
                       0            150           300            450

  Plus Strand HSPs:

 Score = 262 (92.2 bits), Expect = 6.3e-21, P = 6.3e-21
 Identities = 55/161 (34%), Positives = 96/161 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             +Y +RD+EKA  +A+  L++ + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   309 TYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGK 368

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + +T  + ++  +L  R  + P+ F E +K
Sbjct:   369 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMK 428

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   429 LREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARR 469


 >gi|7302938|gb|AAF58009.1|  (AE003807) CG4311 gene product [alt 1] [Drosophila
            melanogaster] >gi|7302939|gb|AAF58010.1| (AE003807) CG4311 gene
            product [alt 2] [Drosophila melanogaster]
            Length = 465

Frame  2 hits (HSPs):                                   _________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 465
                       0              150             300             450

  Plus Strand HSPs:

 Score = 260 (91.5 bits), Expect = 7.1e-21, P = 7.1e-21
 Identities = 57/158 (36%), Positives = 93/158 (58%), Frame = +2

Query:    11 SSYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVG 187
             S+Y +RD+EKA    + +++ ++ + S L+  QVGNMYT S+Y+   SLL       LVG
Sbjct:   299 STYFDRDVEKAFMTQSANIFASKTKKSLLLANQVGNMYTPSVYSGLVSLLISGPAQELVG 358

Query:   188 KRVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMN-VSDKLKQRVEIPPEKFVETLK 364
             KR+ +FSYGSGL A+M+S  + +    F     V+ ++ V   L  R ++ PE+F   ++
Sbjct:   359 KRIGLFSYGSGLAASMYSISVTQDAAAFE--KFVSQLDYVQPLLNSREKVAPEQFSALME 416

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAK 484
             + E       +  +   S L PGT+YL +VD+++RR Y +
Sbjct:   417 VREKNNHAAPYTPTGSISALFPGTYYLKDVDALHRRTYER 456


 >gi|284048|pir||S27197  hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5),
            cytosolic, fibroblast isoform - human >gi|30009|emb|CAA47061.1|
            (X66435) Hydroxymethylglutaryl CoA Synthase [Homo sapiens]
            Length = 520

Frame  2 hits (HSPs):                                _________________    
Annotated Domains:                 __                                     
                        __________________________________________________
Database sequence:     |              |             |              |      | 520
                       0            150           300            450
__________________

Annotated Domains:
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 117..132
__________________


  Plus Strand HSPs:

 Score = 255 (89.8 bits), Expect = 3.7e-20, P = 3.7e-20
 Identities = 54/161 (33%), Positives = 94/161 (58%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             +Y +RD+EKA  +A+  L+  + + S L+  Q GNMYT+S+Y + AS+L   +   L GK
Sbjct:   309 TYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQHLAGK 368

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVT--VMNVSDKLKQRVEIPPEKFVETLK 364
             R+ +FSYGSGL AT++S ++ +   P +  + +T  + ++  +L  R  +  + F E +K
Sbjct:   369 RIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAQDVFAENMK 428

Query:   365 IMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             + E  +   +++       L  GT+YL  VD  +RR YA++
Sbjct:   429 LREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR 469


 >gi|9621905|gb|AAF89580.1|AF166002_1  (AF166002) 3-hydroxy-3-methylglutaryl
            coenzyme A synthase [Dendroctonus jeffreyi]
            Length = 457

Frame  2 hits (HSPs):                                  __________________ 
                        __________________________________________________
Database sequence:     |                |               |                || 457
                       0              150             300              450

  Plus Strand HSPs:

 Score = 251 (88.4 bits), Expect = 6.6e-20, P = 6.6e-20
 Identities = 59/155 (38%), Positives = 86/155 (55%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKN-SSLVGK 190
             SY +RD+EKA   A+   +  R  PS LI   +GNMYT+SLY    S + +++  +LV  
Sbjct:   292 SYFDRDVEKAFLSASNAAFLQRTLPSLLIAANIGNMYTSSLYGGLVSYIVSRSLENLVDN 351

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIM 370
             RV MFSYGSGL ++ +S  ++       L N ++   V   L +R +I PEKF  TL++ 
Sbjct:   352 RVAMFSYGSGLASSFYSITIKNNAALQTLKNNLSY--VEPLLAKRSKIAPEKFEATLELR 409

Query:   371 EHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFY 478
             +       +    D S+  PGTF LT +D  +RR Y
Sbjct:   410 QQSAHKVPYEPVGDISHFFPGTFVLTKIDEQHRRVY 445


 >gi|86312|pir||S13887  hydroxymethylglutaryl-CoA synthase (EC 4.1.3.5) - chicken
            Length = 522

Frame  2 hits (HSPs):                                _________________    
Annotated Domains:                 __                                     
                        __________________________________________________
Database sequence:     |              |             |              |      | 522
                       0            150           300            450
__________________

Annotated Domains:
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 117..132
__________________


  Plus Strand HSPs:

 Score = 250 (88.0 bits), Expect = 1.3e-19, P = 1.3e-19
 Identities = 60/165 (36%), Positives = 98/165 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             +Y +RD+EKA  +A+  L++ + + S L+  Q GNMYT S+Y   ASLL   +   L G+
Sbjct:   310 TYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTPSVYGCLASLLAQYSPEHLAGQ 369

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVE----IPPEKFVET 358
             R+  FSYGSG  AT++S ++ +   P +  + +T  ++SD LK R++    I P+ F E 
Sbjct:   370 RISEFSYGSGFAATLYSIRVTQDATPGSALDKITA-SLSD-LKARLDSRKCIAPDVFAEN 427

Query:   359 LKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKKD*VIG 502
             +KI +  +   +++       L  GT+YL  VD  +RR YA++  V+G
Sbjct:   428 MKIRQETHHLANYIPQCSVEDLFEGTWYLVRVDEKHRRTYARRP-VMG 474


 >gi|123331|sp|P23228|HMCS_CHICK  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC
            (HMG-COA SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|211931|gb|AAA62737.1| (M60657) 3-hydroxy-3-methylglutaryl-CoA
            synthase [Gallus gallus]
            Length = 522

Frame  2 hits (HSPs):                                _________________    
Annotated Domains:       _________________________________________________
                        __________________________________________________
Database sequence:     |              |             |              |      | 522
                       0            150           300            450
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 13..51
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 58..89
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 90..129
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 137..172
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 175..215
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 216..233
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 255..283
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 350..397
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 424..471
   DOMO                 DM01933:                                 13..469
   Entrez               active site: POTENTIAL.                  129
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 13..470
   PRODOM               PD005059: HMCS(7) HMCM(3)                13..60
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     62..192
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        198..265
   PRODOM               PD004407: HMCS(7) HMCM(3)                267..464
   PRODOM               PD017985: HMCS(4)                        466..521
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 117..132
__________________


  Plus Strand HSPs:

 Score = 250 (88.0 bits), Expect = 1.3e-19, P = 1.3e-19
 Identities = 60/165 (36%), Positives = 98/165 (59%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             +Y +RD+EKA  +A+  L++ + + S L+  Q GNMYT S+Y   ASLL   +   L G+
Sbjct:   310 TYFDRDVEKAFMKASAELFNQKTKASLLVSNQNGNMYTPSVYGCLASLLAQYSPEHLAGQ 369

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVE----IPPEKFVET 358
             R+  FSYGSG  AT++S ++ +   P +  + +T  ++SD LK R++    I P+ F E 
Sbjct:   370 RISEFSYGSGFAATLYSIRVTQDATPGSALDKITA-SLSD-LKARLDSRKCIAPDVFAEN 427

Query:   359 LKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKKD*VIG 502
             +KI +  +   +++       L  GT+YL  VD  +RR YA++  V+G
Sbjct:   428 MKIRQETHHLANYIPQCSVEDLFEGTWYLVRVDEKHRRTYARRP-VMG 474


 >gi|555837|gb|AAA92676.1|  (U12791) HMG CoA synthase [Mus musculus]
            Length = 139

Frame  2 hits (HSPs):      ______________________________________________ 
                        __________________________________________________
Database sequence:     |                 |                 |              | 139
                       0                50               100

  Plus Strand HSPs:

 Score = 239 (84.1 bits), Expect = 3.5e-19, P = 3.5e-19
 Identities = 55/127 (43%), Positives = 75/127 (59%), Frame = +2

Query:   113 GNMYTASLYAAFASLL-HNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNI 286
             GNMYT+SLY   ASLL H+    L G R+  FSYGSGL A+ FSF++ +   P + L  +
Sbjct:    10 GNMYTSSLYGCLASLLSHHSAQELAGSRIGAFSYGSGLAASFFSFRVSKDASPGSPLEKL 69

Query:   287 VT-VMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSM 463
             V+ V ++  +L  R  + PE+F E +   E  Y   +F    D S L PGT+YL  VD M
Sbjct:    70 VSSVSDLPKRLDSRRRMSPEEFTEIMNQREQFYHKVNFSPPGDTSNLFPGTWYLERVDEM 129

Query:   464 YRRFYAK 484
             +RR YA+
Sbjct:   130 HRRKYAR 136


 >gi|1708240|sp|P54874|HMCS_SCHPO  HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA
            SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|2130208|pir||S61875 hydroxymethylglutaryl-CoA synthase (EC
            4.1.3.5) - fission yeast (Schizosaccharomyces pombe)
            >gi|974431|gb|AAB17601.1| (U32187) 3-hydroxy-3-methylglutaryl
            coenzyme A synthase [Schizosaccharomyces pombe]
            >gi|2330830|emb|CAB11060.1| (Z98530) hydroxymethylglutaryl-coa
            synthase (EC 4.1.3.5) [Schizosaccharomyces pombe]
            Length = 447

Frame  2 hits (HSPs):                                   __________________
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                |                |                | 447
                       0              150              300
__________________

Annotated Domains:
   BLOCKS               BL01226A: Hydroxymethylglutaryl-coenzyme 4..42
   BLOCKS               BL01226B: Hydroxymethylglutaryl-coenzyme 49..80
   BLOCKS               BL01226C: Hydroxymethylglutaryl-coenzyme 81..120
   BLOCKS               BL01226D: Hydroxymethylglutaryl-coenzyme 126..161
   BLOCKS               BL01226E: Hydroxymethylglutaryl-coenzyme 164..204
   BLOCKS               BL01226F: Hydroxymethylglutaryl-coenzyme 205..222
   BLOCKS               BL01226G: Hydroxymethylglutaryl-coenzyme 241..269
   BLOCKS               BL01226H: Hydroxymethylglutaryl-coenzyme 333..380
   BLOCKS               BL01226I: Hydroxymethylglutaryl-coenzyme 400..447
   DOMO                 DM01933:                                 4..445
   Entrez               active site: POTENTIAL.                  118
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 4..446
   PRODOM               PD005059: HMCS(7) HMCM(3)                6..48
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     51..180
   PRODOM               PD186295: HMCS(7) HMCM(3) HMC1(1)        187..251
   PRODOM               PD209714: HMCS_SCHPO                     253..297
   PRODOM               PD004407: HMCS(7) HMCM(3)                299..440
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 106..121
__________________


  Plus Strand HSPs:

 Score = 234 (82.4 bits), Expect = 4.6e-18, P = 4.6e-18
 Identities = 56/158 (35%), Positives = 85/158 (53%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSS-LVGK 190
             S  ++ LEK      K  ++ RV PS   P   GNMYTAS+++   +LL    +  L GK
Sbjct:   293 SLTDKALEKGLMAITKERFNKRVSPSVYAPTNCGNMYTASIFSCLTALLSRVPADELKGK 352

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIM 370
             RV  +SYGSGL A+ FSF ++ G    ++S I    N+ + L  R  + P ++ E +++ 
Sbjct:   353 RVGAYSYGSGLAASFFSFVVK-G----DVSEIAKKTNLVNDLDNRHCLTPTQYEEAIELR 407

Query:   371 EHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
                +  K+F        L  GT+YLT +D M+RR Y+ K
Sbjct:   408 HQAHLKKNFTPKGSIERLRSGTYYLTGIDDMFRRSYSVK 446


 >gi|11268273|pir||T49718  probable hydroxymethylglutaryl-CoA synthase [imported]
            - Neurospora crassa >gi|7899409|emb|CAB91699.1| (AL356172) probable
            hydroxymethylglutaryl-CoA synthase [Neurospora crassa]
            Length = 454

Frame  2 hits (HSPs):                                   __________________
                        __________________________________________________
Database sequence:     |                |               |                || 454
                       0              150             300              450

  Plus Strand HSPs:

 Score = 233 (82.0 bits), Expect = 6.3e-18, P = 6.3e-18
 Identities = 52/158 (32%), Positives = 86/158 (54%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             S  ++ +EK      K  +  RV P+  +P   GNMY  S++   AS++ H  ++ L GK
Sbjct:   300 SLTDKVVEKTFMTLTKKRFQERVNPAIQVPTLCGNMYCGSVWGGLASIIGHVDSAQLEGK 359

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIM 370
             R+ +FSYGSGL A+  SF++  G    +   +   +N+  +L  R  +PPE +     + 
Sbjct:   360 RIGLFSYGSGLAASFCSFRVT-G----STEKLAKTLNLPARLAARRAVPPESYDAMCDLR 414

Query:   371 EHRYGGKDFVTSKDCSYLTPGTFYLTNVDSMYRRFYAKK 487
             +  +  K++    + S L PGT+YL NVD M++R Y+ K
Sbjct:   415 KQAHLQKNYTPKGEVSTLEPGTYYLENVDDMFKRTYSIK 453


 >gi|555835|gb|AAA92675.1|  (U12790) HMG CoA synthase [Mus musculus]
            Length = 432

Frame  2 hits (HSPs):                                       ______________
                        __________________________________________________
Database sequence:     |                 |                |               | 432
                       0               150              300

  Plus Strand HSPs:

 Score = 195 (68.6 bits), Expect = 8.1e-14, P = 8.1e-14
 Identities = 43/115 (37%), Positives = 70/115 (60%), Frame = +2

Query:    14 SYQNRDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLL-HNKNSSLVGK 190
             +Y N+D++KA  +A+  +++ + + S  +    GNMYT+SLY   ASLL H+    L G 
Sbjct:   318 TYTNKDVDKALLKASLDMFNQKTKASLYLSTNNGNMYTSSLYGCLASLLSHHSAQELAGS 377

Query:   191 RVVMFSYGSGLTATMFSFQLQEGQHPFN-LSNIVT-VMNVSDKLKQRVEIPPEKF 349
             R+  FSYGSGL A+ FSF++ +   P + L  +V+ V ++  +L  R  + PE+F
Sbjct:   378 RIGAFSYGSGLAASFFSFRVSKDASPGSPLEKLVSSVSDLPKRLDSRRRMSPEEF 432


 >gi|1708237|sp|P54871|HMCS_CAEEL  HYDROXYMETHYLGLUTARYL-COA SYNTHASE (HMG-COA
            SYNTHASE) (3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE)
            >gi|1078869|pir||C55729 hydroxymethylglutaryl-CoA synthase homolog
            - Caenorhabditis elegans (fragment) >gi|555829|gb|AAA92672.1|
            (U12787) HMG CoA synthase [Caenorhabditis elegans]
            Length = 458

Frame  2 hits (HSPs):                                   _________________ 
Annotated Domains:      _________________________________________________ 
                        __________________________________________________
Database sequence:     |                |               |                || 458
                       0              150             300              450
__________________

Annotated Domains:
   Entrez               active site: POTENTIAL.                  120
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 6..444
   PROSITE              HMG_COA_SYNTHASE: Hydroxymethylglutaryl- 108..123
__________________


  Plus Strand HSPs:

 Score = 186 (65.5 bits), Expect = 9.0e-13, P = 9.0e-13
 Identities = 43/143 (30%), Positives = 76/143 (53%), Frame = +2

Query:    50 QAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTA 229
             + +  ++  +  P  +  +++GNMYT SL+A   + L   +     K ++ F+YGSGL +
Sbjct:   301 ELSAQVWKEKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLAS 360

Query:   230 TMFSFQLQEGQHPFNLSNIVTV-MNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTS 406
              +F  ++++     NL  I  V +    +L  R++  PE+F ETL+  E     K+   S
Sbjct:   361 AIFPGRVRQTS---NLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKS 417

Query:   407 KDCSYLTPGTFYLTNVDSMYRRFY 478
                + L P T++L N+D +YRR Y
Sbjct:   418 PSETSLFPNTYFLDNMDKLYRRSY 441


 >gi|7499787|pir||T25726  hypothetical protein F25B4.6 - Caenorhabditis elegans
            >gi|1458280|gb|AAB37084.1| (U64842) Similar to
            hydroxymethlglutaryl-CoA synthase; coded for by C. elegans cDNA
            cm01e7 [Caenorhabditis elegans]
            Length = 462

Frame  2 hits (HSPs):                                   _________________ 
                        __________________________________________________
Database sequence:     |                |               |               | | 462
                       0              150             300             450

  Plus Strand HSPs:

 Score = 186 (65.5 bits), Expect = 9.1e-13, P = 9.1e-13
 Identities = 43/143 (30%), Positives = 76/143 (53%), Frame = +2

Query:    50 QAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTA 229
             + +  ++  +  P  +  +++GNMYT SL+A   + L   +     K ++ F+YGSGL +
Sbjct:   305 ELSAQVWKEKTDPYLVFNRRIGNMYTPSLFAQLLAYLAADDCVTGEKSILFFAYGSGLAS 364

Query:   230 TMFSFQLQEGQHPFNLSNIVTV-MNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTS 406
              +F  ++++     NL  I  V +    +L  R++  PE+F ETL+  E     K+   S
Sbjct:   365 AIFPGRVRQTS---NLDKIRQVAIRAIKRLDDRIQFTPEEFTETLQKREVFLRSKEIPKS 421

Query:   407 KDCSYLTPGTFYLTNVDSMYRRFY 478
                + L P T++L N+D +YRR Y
Sbjct:   422 PSETSLFPNTYFLDNMDKLYRRSY 445


 >gi|10581089|gb|AAG19877.1|  (AE005072) 3-hydroxy-3-methylglutaryl-coenzyme A
            synthase; MvaB [Halobacterium sp. NRC-1]
            Length = 445

Frame  2 hits (HSPs):                                     ___________     
                        __________________________________________________
Database sequence:     |                |                |                | 445
                       0              150              300

  Plus Strand HSPs:

 Score = 145 (51.0 bits), Expect = 1.4e-07, P = 1.4e-07
 Identities = 35/94 (37%), Positives = 56/94 (59%), Frame = +2

Query:    53 AAKHLYDARVQPSTLIPKQVGNMYTASLYAA-FASLLHNKNSS--LVGKRVVMFSYGSGL 223
             A +  YDA +QP+  I  QVGN YT S++ A F++L H   +   L GKR+++ SYGSG 
Sbjct:   307 AYREWYDAAIQPTLSISSQVGNWYTGSVHLARFSALKHAAENGIDLAGKRLLVASYGSGA 366

Query:   224 TATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEI 334
              A + S  +Q+G      +  V    + ++++QR +I
Sbjct:   367 QAEIHSETVQDG-----FTEAVAASTIDEQIEQRYDI 398


 >gi|9937404|gb|AAG02453.1|AF290098_1  (AF290098) HMG-CoA synthase [Streptococcus
            pneumoniae]
            Length = 398

Frame  2 hits (HSPs):                                   ________________  
                        __________________________________________________
Database sequence:     |                  |                  |            | 398
                       0                150                300

  Plus Strand HSPs:

 Score = 144 (50.7 bits), Expect = 1.7e-07, P = 1.7e-07
 Identities = 41/126 (32%), Positives = 60/126 (47%), Frame = +2

Query:    32 LEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSY 211
             ++K   Q  K L       S L  ++VGN+YT SL+    SLL N +S   G ++ ++SY
Sbjct:   256 MDKNLPQEKKDLLQKHFDQSILYSQKVGNIYTGSLFLGLLSLLENTDSLKAGDKIALYSY 315

Query:   212 GSGLTATMFSFQLQEGQHPF------NLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIME 373
             GSG  A  FS +L EG   +      N  N  T ++V+D   ++V        ET     
Sbjct:   316 GSGAVAEFFSGELVEGYEAYLDKDRLNKLNQRTALSVADY--EKVFFEEVNLDETNSAQF 373

Query:   374 HRYGGKDF 397
               Y  +DF
Sbjct:   374 AGYENQDF 381


 >gi|9937397|gb|AAG02448.1|AF290096_1  (AF290096) HMG-CoA synthase [Streptococcus
            pyogenes]
            Length = 391

Frame  2 hits (HSPs):                                    _________________
                        __________________________________________________
Database sequence:     |                   |                  |           | 391
                       0                 150                300

  Plus Strand HSPs:

 Score = 139 (48.9 bits), Expect = 1.2e-06, P = 1.2e-06
 Identities = 44/136 (32%), Positives = 66/136 (48%), Frame = +2

Query:    83 QPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQ 262
             Q S    KQ+GN+YT SLY    SLL N      G ++  FSYGSG  +  +S QL  G 
Sbjct:   265 QASITYSKQIGNIYTGSLYLGLLSLLENSKVLQSGDKIGFFSYGSGAVSEFYSGQLVAGY 324

Query:   263 HPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFY 442
                 ++N   +++   +L   V    + F E +++ ++  G  +F    D  YLT G F 
Sbjct:   325 DKMLMTNRQALLDQRTRLS--VSKYEDLFYEQVQLDDN--GNANF----DI-YLT-GKFA 374

Query:   443 LTNVDSMYRRFYAKKD 490
             LT +   ++R Y   D
Sbjct:   375 LTAIKE-HQRIYHTND 389


 >gi|12724576|gb|AAK05670.1|AE006388_1  (AE006388) hydroxymethylglutaryl-CoA
            synthase (EC 4.1.3.5) [Lactococcus lactis subsp. lactis]
            Length = 384

Frame  2 hits (HSPs):                                   __________        
                        __________________________________________________
Database sequence:     |                   |                  |           | 384
                       0                 150                300

  Plus Strand HSPs:

 Score = 135 (47.5 bits), Expect = 4.5e-06, P = 4.5e-06
 Identities = 30/76 (39%), Positives = 44/76 (57%), Frame = +2

Query:    32 LEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSY 211
             LE      A+ L + + +   +  ++VGN+YT SLY +  SLL N +    G+R+ +FSY
Sbjct:   248 LESEKPANAEELME-QFEHGIVYNRRVGNLYTGSLYLSLISLLENSDKLSAGQRIGLFSY 306

Query:   212 GSGLTATMFSFQLQEG 259
             GSG  A  FS +L EG
Sbjct:   307 GSGTVAEFFSGELVEG 322


 >gi|9937390|gb|AAG02443.1|AF290094_1  (AF290094) HMG-CoA synthase [Enterococcus
            faecium]
            Length = 384

Frame  2 hits (HSPs):                                   ______________    
                        __________________________________________________
Database sequence:     |                   |                  |           | 384
                       0                 150                300

  Plus Strand HSPs:

 Score = 133 (46.8 bits), Expect = 8.1e-06, P = 8.1e-06
 Identities = 34/110 (30%), Positives = 56/110 (50%), Frame = +2

Query:    32 LEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSY 211
             L++ ++   + L  AR + S    +++GN+YT SLY    SLL N  S   G R+ +FSY
Sbjct:   248 LDQTDEDNQERLM-ARYEESIRYSRRIGNLYTGSLYLGLTSLLENSKSLQPGDRIGLFSY 306

Query:   212 GSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETL 361
             GSG  +  F+  L+E     N    +   +  + L  R  I  +++ ET+
Sbjct:   307 GSGAVSEFFTGYLEE-----NYQEYLFAQSHQEMLDSRTRITVDEY-ETI 350


 >gi|9937383|gb|AAG02438.1|AF290092_1  (AF290092) HMG-CoA synthase [Enterococcus
            faecalis]
            Length = 383

Frame  2 hits (HSPs):                                    _________        
                        __________________________________________________
Database sequence:     |                   |                   |          | 383
                       0                 150                 300

  Plus Strand HSPs:

 Score = 130 (45.8 bits), Expect = 2.0e-05, P = 2.0e-05
 Identities = 26/62 (41%), Positives = 37/62 (59%), Frame = +2

Query:    74 ARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQ 253
             AR + S +  ++VGN+YT SLY    SLL N  +   G ++ +FSYGSG  A  F+ +L 
Sbjct:   261 ARYEESIIYSRRVGNLYTGSLYLGLISLLENATTLTAGNQIGLFSYGSGAVAEFFTGELV 320

Query:   254 EG 259
              G
Sbjct:   321 AG 322


 >gi|11356423|pir||T44125  hypothetical protein [imported] - Staphylococcus
            aureus  (fragment)
            Length = 129

Frame  2 hits (HSPs):       ______________________________________________
                        __________________________________________________
Database sequence:     |                  |                   |           | 129
                       0                 50                 100

  Plus Strand HSPs:

 Score = 104 (36.6 bits), Expect = 0.00013, P = 0.00013
 Identities = 34/128 (26%), Positives = 65/128 (50%), Frame = +2

Query:   104 KQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQHPFNLSN 283
             + VGN+YT SLY +  SLL N ++    ++V +FSYGSG    +FS  + +G       +
Sbjct:    12 RDVGNIYTGSLYLSLISLLQN-HTFQPEEKVCLFSYGSGAVGEIFSGSIVKGYD--KALD 68

Query:   284 IVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSM 463
                 +N+   L+ R ++  E++ ET     +R+  ++F   ++ +       YL +++  
Sbjct:    69 KEKHLNM---LESREQLSVEEY-ETFF---NRFDNQEFDFERELTQDPYSKVYLYSIEDH 121

Query:   464 YRRFYAKK 487
              R +  +K
Sbjct:   122 IRTYKIEK 129


 >gi|9937368|gb|AAG02427.1|AF290088_1  (AF290088) HMG-CoA synthase
            [Staphylococcus haemolyticus]
            Length = 388

Frame  2 hits (HSPs):                                     ________________
                        __________________________________________________
Database sequence:     |                   |                  |           | 388
                       0                 150                300

  Plus Strand HSPs:

 Score = 121 (42.6 bits), Expect = 0.00029, P = 0.00029
 Identities = 37/128 (28%), Positives = 62/128 (48%), Frame = +2

Query:   104 KQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEG-QHPFNLS 280
             + VGN+YT SLY +  SLL N+ S   G+ + +FSYGSG     FS  L EG +   ++ 
Sbjct:   271 RYVGNIYTGSLYLSLISLLENR-SLKGGQTIGLFSYGSGSVGEFFSATLVEGYEKQLDIE 329

Query:   281 NIVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDS 460
                 ++N      +R E+  E +    K    R+   +F  + + +      +YL N+  
Sbjct:   330 GHKALLN------ERQEVSVEDYESFFK----RFDDLEFDHATEQTDDDKSIYYLENIQD 379

Query:   461 MYRRFYAKK 487
               R+++  K
Sbjct:   380 DIRQYHIPK 388


 >gi|9937361|gb|AAG02422.1|AF290086_1  (AF290086) HMG-CoA synthase
            [Staphylococcus aureus]
            Length = 388

Frame  2 hits (HSPs):                                     ________________
                        __________________________________________________
Database sequence:     |                   |                  |           | 388
                       0                 150                300

  Plus Strand HSPs:

 Score = 120 (42.2 bits), Expect = 0.00039, P = 0.00039
 Identities = 35/125 (28%), Positives = 59/125 (47%), Frame = +2

Query:   104 KQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQHPFNLSN 283
             + VGN+YT SLY +  SLL N++    G+ + +FSYGSG     +S  L  G +  +L  
Sbjct:   271 RYVGNIYTGSLYLSLISLLENRDLQ-AGETIGLFSYGSGSVVEFYSATLVVG-YKDHLDQ 328

Query:   284 IVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSM 463
                       L  R E+  + +    K    R+   +F   +D  +     FYL+N+++ 
Sbjct:   329 AAH----KALLNNRTEVSVDAYETFFK----RFDDVEFDEEQDAVHEDRHIFYLSNIENN 380

Query:   464 YRRFY 478
              R ++
Sbjct:   381 VREYH 385


 >gi|9937376|gb|AAG02433.1|AF290090_1  (AF290090) HMG-CoA synthase
            [Staphylococcus epidermidis]
            Length = 388

Frame  2 hits (HSPs):                                     ________________
                        __________________________________________________
Database sequence:     |                   |                  |           | 388
                       0                 150                300

  Plus Strand HSPs:

 Score = 112 (39.4 bits), Expect = 0.0037, P = 0.0036
 Identities = 34/125 (27%), Positives = 57/125 (45%), Frame = +2

Query:   104 KQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQHPFNLSN 283
             + VGN+YT SLY +  SLL  ++    G+ + +FSYGSG     FS  L +G        
Sbjct:   271 RYVGNIYTGSLYLSLISLLETRDLK-GGQTIGLFSYGSGSVGEFFSGTLVDG-----FKE 324

Query:   284 IVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSM 463
              + V      L  R+E+  +++    K    R+   +     + S      FYL ++D+ 
Sbjct:   325 QLDVERHKSLLNNRIEVSVDEYEHFFK----RFDQLELNHELEKSNADRDIFYLKSIDNN 380

Query:   464 YRRFY 478
              R ++
Sbjct:   381 IREYH 385


 >gi|5419956|emb|CAB46505.1|  (AJ132503) TaF protein [Myxococcus xanthus]
            Length = 374

Frame  2 hits (HSPs):                                _______________      
                        __________________________________________________
Database sequence:     |                   |                   |          | 374
                       0                 150                 300

  Plus Strand HSPs:

 Score = 110 (38.7 bits), Expect = 0.0059, P = 0.0059
 Identities = 33/113 (29%), Positives = 59/113 (52%), Frame = +2

Query:    26 RDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMF 205
             R+L   +    +  +  RV+PS   P  VGN+ + S+Y +  S++          RV MF
Sbjct:   220 RELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYLSLCSIIDTIKPER-SARVGMF 278

Query:   206 SYGSGLTATMFSFQLQEGQHPFNLSNIVTVMNVSDKLKQRVEIPPEKFVETLK 364
             SYGSG ++  FS  +  G  P ++S +   +++   L+ R ++  +++VE LK
Sbjct:   279 SYGSGCSSEFFSGVI--G--PESVSALAG-LDIGGHLRGRRQLTFDQYVELLK 326


 >gi|4096796|gb|AAD10460.1|  (U40157) orf1; unknown function;  similar to
            condensing-enzymes; Method: conceptual translation supplied by
            author. [Staphylococcus carnosus]
            Length = 389

Frame  2 hits (HSPs):                                     ________________
                        __________________________________________________
Database sequence:     |                   |                  |           | 389
                       0                 150                300

  Plus Strand HSPs:

 Score = 110 (38.7 bits), Expect = 0.0063, P = 0.0062
 Identities = 35/124 (28%), Positives = 54/124 (43%), Frame = +2

Query:   104 KQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMFSFQLQEGQHPFNLSN 283
             + VGN+YT SLY +  SLL N   +  G  + +FSYGSG     FS  L +     N  +
Sbjct:   272 RYVGNVYTGSLYLSLISLLENHKLN-GGDNIGLFSYGSGSVGEFFSATLVD-----NYQD 325

Query:   284 IVTVMNVSDKLKQRVEIPPEKFVETLKIMEHRYGGKDFVTSKDCSYLTPGTFYLTNVDSM 463
              + V      L  R  +  E++ +      +R+   +F T  +      G FYL  +   
Sbjct:   326 HLDVKAHKAMLDNRKALSVEEYEKFF----NRFDNLEFDTETELEVEPKGNFYLKEISDN 381

Query:   464 YRRF 475
              R +
Sbjct:   382 IRYY 385


 >gi|9711351|dbj|BAB07822.1|  (AB037907) HMG-CoA synthase [Streptomyces
            griseolosporeus]
            Length = 346

Frame  2 hits (HSPs):                                   ________          
                        __________________________________________________
Database sequence:     |                     |                     |      | 346
                       0                   150                   300

  Plus Strand HSPs:

 Score = 97 (34.1 bits), Expect = 0.18, P = 0.16
 Identities = 21/50 (42%), Positives = 30/50 (60%), Frame = +2

Query:    89 STLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMF 238
             +T   + +GN YTAS+Y   A+LL ++   L G+R+   SYGSG  A  F
Sbjct:   226 TTAYNRVIGNSYTASVYLGLAALL-DQADDLTGERIGFLSYGSGSVAEFF 274


 >gi|9695275|dbj|BAB07795.1|  (AB037666) 3-hydroxy-3-methylglutaryl CoA synthase
            [Streptomyces sp. CL190]
            Length = 389

Frame  2 hits (HSPs):                                    ________         
                        __________________________________________________
Database sequence:     |                   |                  |           | 389
                       0                 150                300

  Plus Strand HSPs:

 Score = 95 (33.4 bits), Expect = 0.37, P = 0.31
 Identities = 22/61 (36%), Positives = 32/61 (52%), Frame = +2

Query:    59 KHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMFSYGSGLTATMF 238
             K   +  +  +T     +GN YTAS+Y   A+LL ++   L G+ +   SYGSG  A  F
Sbjct:   259 KDAIEGALGQTTAYNNVIGNSYTASVYLGLAALL-DQADDLTGRSIGFLSYGSGSVAEFF 317

Query:   239 S 241
             S
Sbjct:   318 S 318


 >gi|730331|sp|P40830|PKSG_BACSU  PUTATIVE POLYKETIDE BIOSYNTHESIS PROTEIN PKSG
            >gi|7475585|pir||E69678 involved in polyketide synthesis pksG -
            Bacillus subtilis >gi|528991|gb|AAA85140.1| (U11039) unknown
            [Bacillus subtilis] >gi|2634085|emb|CAB13586.1| (Z99112) pksG
            [Bacillus subtilis] >gi|2634097|emb|CAB13597.1| (Z99113) pksG
            [Bacillus subtilis]
            Length = 345

Frame  2 hits (HSPs):                              ______________         
Annotated Domains:      __________________________________________________
                        __________________________________________________
Database sequence:     |                     |                     |      | 345
                       0                   150                   300
__________________

Annotated Domains:
   PFAM                 HMG_CoA_synt: Hydroxymethylglutaryl-coen 2..344
   PRODOM               PD000453: CHSY(16) CHS1(11) CHS2(11)     1..133
   PRODOM               PD004407: HMCS(7) HMCM(3)                140..340
__________________


  Plus Strand HSPs:

 Score = 84 (29.6 bits), Expect = 5.8, P = 1.0
 Identities = 27/87 (31%), Positives = 41/87 (47%), Frame = +2

Query:    26 RDLEKANQQAAKHLYDARVQPSTLIPKQVGNMYTASLYAAFASLLHNKNSSLVGKRVVMF 205
             R + K      +  +  RV+P     ++VGN+  A+L+ A AS +         KR+  F
Sbjct:   191 RKVAKVKTSGIETDFLTRVKPGLNYCQRVGNIMGAALFLALASTIDQGRFD-TPKRIGCF 249

Query:   206 SYGSGLTATMFSF----QLQEGQHPFNL 277
             SYGSG  +  +S     Q QE Q  F +
Sbjct:   250 SYGSGCCSEFYSGITTPQGQERQRTFGI 277


Parameters:
  filter=none
  matrix=BLOSUM62
  V=50
  B=50
  E=10
  gi
  H=1
  sort_by_pvalue
  echofilter

  ctxfactor=5.98

  Query                        -----  As Used  -----    -----  Computed  ----
  Frame  MatID Matrix name     Lambda    K       H      Lambda    K       H
   Std.    0   BLOSUM62                                 0.318   0.135   0.401  
   +3      0   BLOSUM62        0.318   0.135   0.401    0.369   0.160   0.586  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   +2      0   BLOSUM62        0.318   0.135   0.401    0.334   0.145   0.439  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   +1      0   BLOSUM62        0.318   0.135   0.401    0.359   0.159   0.628  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -1      0   BLOSUM62        0.318   0.135   0.401    0.344   0.148   0.544  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -2      0   BLOSUM62        0.318   0.135   0.401    0.351   0.155   0.554  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a
   -3      0   BLOSUM62        0.318   0.135   0.401    0.360   0.161   0.575  
               Q=9,R=2         0.244   0.0300  0.180     n/a     n/a     n/a

  Query
  Frame  MatID  Length  Eff.Length     E    S W   T  X   E2     S2
   +3      0      203       202       10.  77 3  12 22  0.095   35
                                                    31  0.11    38
   +2      0      203       203       10.  77 3  12 22  0.095   35
                                                    31  0.11    38
   +1      0      203       202       10.  77 3  12 22  0.095   35
                                                    31  0.11    38
   -1      0      203       202       10.  77 3  12 22  0.095   35
                                                    31  0.11    38
   -2      0      203       202       10.  77 3  12 22  0.095   35
                                                    31  0.11    38
   -3      0      203       203       10.  77 3  12 22  0.095   35
                                                    31  0.11    38


Statistics:

  Database:  /usr/local/dot5/sl_home/beauty/seqdb/blast/nr
    Title:  nr
    Release date:  unknown
    Posted date:  4:06 PM CST Feb 28, 2001
    Format:  BLAST
  # of letters in database:  197,782,623
  # of sequences in database:  625,274
  # of database sequences satisfying E:  49
  No. of states in DFA:  597 (59 KB)
  Total size of DFA:  231 KB (256 KB)
  Time to generate neighborhood:  0.02u 0.00s 0.02t  Elapsed: 00:00:00
  No. of threads or processors used:  6
  Search cpu time:  227.01u 1.06s 228.07t  Elapsed: 00:01:52
  Total cpu time:  227.09u 1.11s 228.20t  Elapsed: 00:01:52
  Start:  Wed Jan 23 19:07:51 2002   End:  Wed Jan 23 19:09:43 2002


Annotated Domains Database:   March 14, 2000 

Release Date:  March 14, 2000