| US 7,354,389 B2 | ||
| Microarray detector and methods | ||
| Fareed Kureshy, Del Mar, Calif. (US); Vijay K. Mahant, Murrieta, Calif. (US); Shailendra Singh, Carlsbad, Calif. (US); and Xiaohua Shen, San Jose, Calif. (US) | ||
| Assigned to Autogenomics, Inc., Carlsbad, Calif. (US) | ||
| Appl. No. 10/509,985 PCT Filed May 28, 2003, PCT No. PCT/US03/17073 § 371(c)(1), (2), (4) Date Nov. 16, 2004, PCT Pub. No. WO03/100474, PCT Pub. Date Dec. 04, 2003. |
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| Claims priority of provisional application 60/383896, filed on May 28, 2002. | ||
| Prior Publication US 2005/0118640 A1, Jun. 02, 2005 | ||
| Int. Cl. C40B 60/08 (2006.01) | ||
| U.S. Cl. 506—37 [435/6] | 13 Claims |
| 1. An analytic system for optical detection of a plurality of analytes that are bound to a biochip, the analytic system comprising:
a platform functionally coupled to a confocal microscope detector and movable along an x-coordinate, a y-coordinate, and optionally
a z-coordinate relative to the detector, wherein the platform is configured to receive a biochip;
wherein the biochip has a plurality of registration markers and further has a plurality of analytes in predetermined positions
relative to the registration markers;
a first light source that is configured to illuminate the registration markers at a first angle relative to the z-coordinate
to generate registration marker signals, and further comprising a second light source that is configured to sequentially illuminate
at least two of the plurality of analytes at a second angle relative to the z-coordinate to generate at least two individual
analyte signals, respectively;
a computer configured to determine the position of the biochip with respect to a given x-coordinate value and a given y-coordinate
value using the registration marker signals; and
wherein the first and the second angles are different.
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