Shelton J, Morse GD, Hewitt RG; National Conference on Human Retroviruses and Related Infections.
Program Abstr Second Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 2nd 1995 Wash DC. 1995 Jan 29-Feb 2; 146.
State University of New York at Buffalo, Buffalo, NY.
Since the incidence of GH in HIV-infected patients is controversial, we established a screening program among our patients receiving antiretroviral therapy using a radiotelemetry device (Heidelberg capsule). After an overnight fast of at least 8 h, patients with no history of gastrointestinal maladies or surgery (with the exception of oral/esophageal candidiasis or appendectomy) were evaluated between the hours of 8 and 10 AM. Patients were considered to have GH when their intrapatient mean pH was greater than 3. Demographics, such as age, sex, race, and CD4 counts were collected and compared between patients with and without GH using analysis of variance. Serum gastrin was measured in a subgroup of patients. GH was detected in 6/31 (19%) patients. All patients with GH had serum gastrin greater than 50 pg/ml, while 4 without GH had serum gastrin less than 50 pg/ml. Patients with GH tended to be African- American or Hispanic (5/6 patients with GH vs. 9/25 without GH). This pilot study suggests that GH in HIV patients may be related to CD4%. The clinical significance of GH is unknown, but its impact on the absorption of drugs requiring an acid milieu (eg. itraconazole, dapsone, and delavirdine) needs to be addressed.
Publication Types:
Keywords:
- AIDS Vaccines
- Achlorhydria
- Acquired Immunodeficiency Syndrome
- African Americans
- CD4 Lymphocyte Count
- Candidiasis
- Delavirdine
- Gastrins
- HIV Infections
- HIV Seropositivity
- Hispanic Americans
- Humans
- Incidence
- Itraconazole
- Outpatients
Other ID:
UI: 102213475
From Meeting Abstracts