Gomila M, Domingo P, Sambeat MA, Arroyo JA, Cadafalch J, Fontanet A, Fuster M, Orellana I, Marinez-Bru C, Gurgui M, Vazquez G; International Conference on AIDS.

Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. TuPeB4538.

Hospital de St. Pau, Barcelona, Spain

BACKGROUND: Non-nucleoside reverse transcriptase inhibitors (NNRTIs), specially nevirapine are known to cause hepatic dysfunction, and in some instances hepatitis. Aim of the study: to prospectively follow-up liver function tests in patients randomized to receive either indinavir (IDV) or nevirapine (NVP) together with stavudine and didanosine. Patients and METHODS: Antiretroviral naive HIV-1-infected patients were randomized to start combination antiretroviral therapy with either IDV or NVP and stavudine plus didanosine. AST, ALT, bilirrubin, alkaline phosphatase (AP) and gamma glutamyl transpeptidase (GGT) were determined at baseline, 3, 6, 9, and 12 months of follow-up. AST, ALT and AP were measured by colorimetric methods (DGKCH at 37˚C) whereas GGT was measured by SZASZ at 37˚C. Statistical analyses were performed with the StatViewTM 4.5 statistical package. RESULTS: There were 81 men and 21 women, with a mean age of 39.3 +-9.9 years (range: 18-66). Thirty-five patients had a stage C3 HIV infection. Forty-seven patients were randomized to IDV and 55 to NVP. Twenty-one (30%) patients had hepatitis C infection. There were no statistically significant differences between groups with respect to baseline CD4 count and viral load. Bilirrubin levels significantly increased in patients taking IDV at all time points, whereas AST, ALT, AP, and GGT did not experience significant increases. AP and GGT significantly increased in patients taking NVP at all time points (p < 0.05), whereas bilirrubin, AST, and ALT did not experience significant changes. No patient presented with clinical hepatitis. CONCLUSIONS: Indinavir increased only bilirrubin levels without causing changes in th other liver function tests, whereas NVP significantly increased cholestasis markers but not cytolisis enzymes.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Alanine Transaminase
• Aspartate Aminotransferases
• CD4 Lymphocyte Count
• Didanosine
• Female
• HIV Infections
• HIV Seropositivity
• HIV-1
• Humans
• Indinavir
• Liver Function Tests
• Longitudinal Studies
• Male
• Nevirapine
• Reverse Transcriptase Inhibitors
• Stavudine
• Viral Load

Other ID:

• GWAIDS0020657

UI: 102259723

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