Signal transduction

GeneDescriptionSequencesSequence assemblyPredicted SNPs having score >= 0.99
ABL1V-abl Abelson murine leukemia viral oncogene homolog 1M14752, X16416X16416
4
ABL2V-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)M35296
ABRActive BCR-related geneL19704, U01147U01147
ACVR1BActivin A receptor, type IBZ22536
ADKAdenosine kinaseU50196U50196
ADRBK1Adrenergic, beta, receptor kinase 1M80776, U08435, U08436, U08437, U08438, X61157U08438
AK1Adenylate kinase 1J04809J04809
1
AK2Adenylate kinase 2U39945, U54645U54645
3
AK3Adenylate kinase 3X60673X60673
1
AKT1V-akt murine thymoma viral oncogene homolog 1M63167M63167
AKT2V-akt murine thymoma viral oncogene homolog 2M77198, M95936M77198
ALOX12Arachidonate 12-lipoxygenaseM35418, M58704, M62982
ALOX5Arachidonate 5-lipoxygenaseJ03571, J03600J03600
1
ARAF1V-raf murine sarcoma 3611 viral oncogene homolog 1L24038, U01337, X04790L24038
ARHARas homolog gene family, member AL09159, L25080, X05026L25080
Location 1 (2)
Location 2 (2)
ARHCRas homolog gene family, member CL25081L25081
ARHGDIBRho GDP dissociation inhibitor (GDI) betaL07916, L20688L20688
2
BLKB lymphoid tyrosine kinaseS76617, Z33998S76617
1
BMPR2Bone morphogenetic protein receptor, type II (serine/threonine kinase)D50516, Z48923Z48923
BMXBMX non-receptor tyrosine kinaseX83107, AF045459
BRAFV-raf murine sarcoma viral oncogene homolog B1M95712, M95720, X54072M95712
BTKBruton agammaglobulinemia tyrosine kinaseU10087, X58957U01923
U78027
3
CAKCell adhesion kinaseL20817, Z29093U48705
Z29093
1
CALM1Calmodulin 1 (phosphorylase kinase, delta)M27319U12022
1
CAMK4Calcium/calmodulin-dependent protein kinase IVD30742
CBLBCas-Br-M (murine) ectropic retroviral transforming sequence bU26710, U26711, U26712U26710
CCNHCyclin HU11791, U12685U11791
CDC2L1Cell division cycle 2-like 1 (PITSLRE proteins)M37712, U04815M37712
Location 1 (2)
Location 2 (1)
Location 3 (3)
CDC42Cell division cycle 42 (GTP-binding protein, 25kD)M35543, M57298L10844
1
CDC42Cell division cycle 42 (GTP-binding protein, 25kD)M35543, M57298L10844
1
CDC7L1CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1AF015592AF015592
CDK2Cyclin-dependent kinase 2M68520, X61622, X62071M68520
CDK5Cyclin-dependent kinase 5X66364L04658
1
CDK6Cyclin-dependent kinase 6X66365X66365
CDK7Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)L20320, X77303, X77743, X79193L20320
CDK8Cyclin-dependent kinase 8X85753X85753
CDKN2BCyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)L36844, U17075, AF004819
CHEK1CHK1 (checkpoint, S.pombe) homologAF016582AF016582
CHN1Chimerin (chimaerin) 1X51408, Z22641X51408
1
CHN2Chimerin (chimaerin) 2U28926U07223
1
CHUKConserved helix-loop-helix ubiquitous kinaseAF009225
CIS4STAT induced STAT inhibitor-4AB006968
CKS1CDC28 protein kinase 1X54941X54941
1
CKS2CDC28 protein kinase 2X54942X54942
1
CLGNCalmeginD86322D86322
CLK2CDC-like kinase 2AF023268AF023268
J03060
L29218
U46920
CLK3CDC-like kinase 3L29217L29217
CNKCytokine-inducible kinaseU56998U56998
COTCot (cancer Osaka thyroid) oncogeneD14497D14497
1
CSKC-src tyrosine kinaseX60114X60114
2
CSNK1A1Casein kinase 1, alpha 1L37042, X80693L37042
1
CSNK1DCasein kinase 1, deltaU29171U29171
CSNK1ECasein kinase 1, epsilonL37043L37043
CSNK2A2Casein kinase 2, alpha prime polypeptideM55268M55268
CSNK2BCasein kinase 2, beta polypeptideM30448
CTNNA1Catenin (cadherin-associated protein), alpha 1 (102kD)D14705, L23805U03100
Location 1 (1)
Location 2 (1)
CTNNB1Catenin (cadherin-associated protein), beta 1 (88kD)X87838, Z19054X87838
CTNND2Catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)U52828, U96136U96136
DGKADiacylglycerol kinase, alpha (80kD)X62535, AF064767X62535
DGKGDiacylglycerol kinase, gamma (90kD)AF020945D26135
DGKQDiacylglycerol kinase, theta (110kD)L38707
DMPKDystrophia myotonica-protein kinaseL08835, L19268L08835
1
DRG2Developmentally regulated GTP-binding protein 2X80754X80754
1
DVL3Dishevelled 3 (homologous to Drosophila dsh)U49262, AF006013D86963
DYRK1Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1D85759, D86550, U52373, U58496, AB015282D86550
1
DYRK1BDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1BY17999Y17999
DYRK2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2Y09216, Y13493Y13493
Location 1 (1)
Location 2 (1)
DYRK3Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3Y12735Y12735
DYRK4Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4Y09305Y09305
EFNA1Ephrin-A1M57730M57730
3
EFNA5Ephrin-A5U26403
EFNB1Ephrin-B1U09303U09303
1
EFNB2Ephrin-B2U16797U81262
EGFREpidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)X00588X00588
EPHA2EphA2M59371M59371
EPHA4EphA4L36645
EPHA5EphA5L36644
EPHA7EphA7L36642
EPHB3EphB3X75208X75208
EPHB4EphB4U07695U07695
EPHB6EphB6D83492D83492
ERBB2V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)M11730, X03363M11730
ERBB3V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3M29366, M34309, S61953S61953
M34309
ERBB4V-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4L07868
FBLFibrillarinM59849, X56597X56597
FERFer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)J03358
FESFeline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homologX06292
FGFR1Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)M34185, M34641X66945
FGFR2Fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)M87770, M87771M87770
1
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologM12502, M19722M19722
FLT1Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)S77812, S77814, X51602X51602
FLT3LGFms-related tyrosine kinase 3 ligandU03858, U04806
FLT4Fms-related tyrosine kinase 4X68203, X69878
FRKFyn-related kinaseU00803, U22322
FYBFYN-binding protein (FYB-120/130)AF001862, AF001863AF001862
FYNFYN oncogene related to SRC, FGR, YESM14333, M14676Z97989
GLAGalactosidase, alphaU78027, X14448U01923
U78027
3
GNAI1Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1J03005, M27543M27543
1
GNG10Guanine nucleotide binding protein 10U31383U31383
1
GPRK6G protein-coupled receptor kinase 6L16862L16862
GRB2Growth factor receptor-bound protein 2L29511, M96995M96995
GUCY1B3Guanylate cyclase 1, soluble, beta 3X66533X66533
2
HCKHemopoietic cell kinaseM16591, M16592M16591
HIPK3Homeodomain-interacting protein kinase 3Y09306, AF004849AF004849
HRKHarakiri, BCL2-interacting protein (contains only BH3 domain)U76376
ILKIntegrin-linked kinaseU40282U40282
IRAK1Interleukin-1 receptor-associated kinase 1L76191L76191
U52112
IRAK2Interleukin-1 receptor-associated kinase 2AF026273
ITPKBInositol 1,4,5-trisphosphate 3-kinase BX57206X57206
JAK1Janus kinase 1 (a protein tyrosine kinase)M64174M64174
JAK2Janus kinase 2 (a protein tyrosine kinase)AF005216
JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)U09607
KDRKinase insert domain receptor (a type III receptor tyrosine kinase)L04947, X61656AF035121
KIAA0641Apoptosis-associated tyrosine kinaseAB014541
LCATLecithin-cholesterol acyltransferaseM12625, X04981
LCKLymphocyte-specific protein tyrosine kinaseM36881, U07236X05027
LIMK1LIM domain kinase 1D26309, U63721M36860
U63721
1
LIMK2LIM domain kinase 2D45906D45906
LTKLeukocyte tyrosine kinaseD16105, X60702
LYNV-yes-1 Yamaguchi sarcoma viral related oncogene homologM16038M16038
1
MACSMyristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)D10522, M68956D10522
2
MADH1MAD (mothers against decapentaplegic, Drosophila) homolog 1U59912U59423
1
MADH2MAD (mothers against decapentaplegic, Drosophila) homolog 2AF027964U68018
1
MADH3MAD (mothers against decapentaplegic, Drosophila) homolog 3U68019U68019
MAPKAPK2Mitogen-activated protein kinase-activated protein kinase 2U12779, X75346U12779
1
MAPKAPK5Mitogen-activated protein kinase-activated protein kinase 5AF032437, AG032437AF032437
MATKMegakaryocyte-associated tyrosine kinaseL18974, S75168
MEKK3MAP/ERK kinase kinase 3U78876
MEKK4MAP/ERK kinase kinase 4D86968, AF002715D86968
1
MEKK5MAP/ERK kinase kinase 5D84476, U67156U67156
2
MST1RMacrophage stimulating 1 receptor (c-met-related tyrosine kinase)X70040X70040
NCK1NCK adaptor protein 1X17576X17576
NEK3NIMA (never in mitosis gene a)-related kinaseZ29067Z29067
1
NME1Non-metastatic cells 1, protein (NM23A) expressed inX17620X17620
NME2Non-metastatic cells 2, protein (NM23B) expressed inL16785, X58965M36981
1
NMIN-myc (and STAT) interactorU32849U32849
1
NPM1Nucleophosmin (nucleolar phosphoprotein B23, numatrin)J02590, M23613, M26697U89322
1
NTRK1Neurotrophic tyrosine kinase, receptor, type 1X03541, Y09028, Y09029, Y09030, Y09031, Y09032, Y09033, Y09034, Y09035, Y09036, AB019488M23102
AC004079
NTRK2Neurotrophic tyrosine kinase, receptor, type 2U12140U12140
NTRK3Neurotrophic tyrosine kinase, receptor, type 3U05012U05012
NTRKR1Neurotrophic tyrosine kinase, receptor-related 1M97675, U38894M97675
3
NTRKR2Neurotrophic tyrosine kinase, receptor-related 2M97639M97639
NTRKR3Neurotrophic tyrosine kinase, receptor-related 3X74764X74764
1
PCTK3PCTAIRE protein kinase 3X66362X66362
2
PDE4BPhosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)L12686, L20966, L20971, U85048L20971
PDGFAPlatelet-derived growth factor alpha polypeptideM20488, M20489, M20490, M20491, M20492, M20493, M20494, X03795, X06374X06374
PDGFBPlatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)K01913, K01914, K01915, K01916, K01917, M12783M12783
PDGFRAPlatelet-derived growth factor receptor, alpha polypeptideD50001, D50002, D50003, D50004, D50005, D50006, D50007, D50008, D50009, D50010, D50011, D50012, D50013, D50014, D50015, D50016, D50017, M21574M21574
PDGFRBPlatelet-derived growth factor receptor, beta polypeptideJ03278, M21616J03278
2
PDGFRLPlatelet-derived growth factor receptor-likeD37965D37965
1
PDK2Pyruvate dehydrogenase kinase, isoenzyme 2L42451L42451
2
PDK4Pyruvate dehydrogenase kinase, isoenzyme 4U54617
PDPK13-phosphoinositide dependent protein kinase-1Y15056AF017995
1
PHKA2Phosphorylase kinase, alpha 2 (liver), glycogen storage disease IXD38616, X80497X80497
PHKG2Phosphorylase kinase, gamma 2 (testis)M31606, Y11950, Y11951M31606
PIASX-BETAProtein inhibitor of activated STAT XAF077953, AF077954AF077954
PIK3C3Phosphoinositide-3-kinase, class 3Z46973Z46973
1
PIK3CAPhosphoinositide-3-kinase, catalytic, alpha polypeptideZ29090Z29090
PIK3CAPhosphoinositide-3-kinase, catalytic, alpha polypeptideZ29090Z29090
PIK3CGPhosphoinositide-3-kinase, catalytic, gamma polypeptideX83368X83368
PIM1Pim-1 oncogeneM16750, M24779, M54915M54915
3
PLA2G2APhospholipase A2, group IIA (platelets, synovial fluid)M22430M22430
3
PLCB4Phospholipase C, beta 4L41349AL031652
PLCEPhospholipase C, epsilonD42108D42108
PLCG2Phospholipase C, gamma 2 (phosphatidylinositol-specific)M37238M37238
1
PPP2R5AProtein phosphatase 2, regulatory subunit B (B56), alpha isoformL42373L42373
2
PPP2R5BProtein phosphatase 2, regulatory subunit B (B56), beta isoformL42374L42374
PPP2R5CProtein phosphatase 2, regulatory subunit B (B56), gamma isoformL42375
PPP2R5DProtein phosphatase 2, regulatory subunit B (B56), delta isoformL76702L76702
1
PPP2R5EProtein phosphatase 2, regulatory subunit B (B56), epsilon isoformL76703L76703
PRKAA2Protein kinase, AMP-activated, alpha 2 catalytic subunitU06454
PRKACAProtein kinase, cAMP-dependent, catalytic, alphaX07767X07767
1
PRKACBProtein kinase, cAMP-dependent, catalytic, betaM34181M34181
PRKACGProtein kinase, cAMP-dependent, catalytic, gammaM34182
PRKAG1Protein kinase, AMP-activated, gamma 1 non-catalytic subunitU42412U42412
PRKAR1AProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)M18468, M33336M33336
4
PRKAR1BProtein kinase, cAMP-dependent, regulatory, type I, betaM65066M65066
Location 1 (2)
Location 2 (1)
PRKAR2BProtein kinase, cAMP-dependent, regulatory, type II, betaM31158M31158
1
PRKCAProtein kinase C, alphaX52479X52479
PRKCB1Protein kinase C, beta 1X06318X07109
PRKCGProtein kinase C, gammaM13977, Z15114
PRKCIProtein kinase C, iotaL18964L33881
PRKCL1Protein kinase C-like 1S75546U33053
2
PRKCL2Protein kinase C-like 2U33052U33052
PRKCMProtein kinase C, muX75756X75756
1
PRKCQProtein kinase C, thetaL01087L01087
PRKCZProtein kinase C, zetaL14283, Z15108Z15108
1
PRKG1Protein kinase, cGMP-dependent, type IY07512
PRKG2Protein kinase, cGMP-dependent, type IIX94612
PRKM1Protein kinase, mitogen-activated 1 (MAP kinase 1; p40, p41)Z11694, Z11695Z11695
1
PRKM10Protein kinase mitogen-activated 10 (MAP kinase)U07620U07620
PRKM11Protein kinase mitogen- activated 11Y14440
PRKM13Protein kinase mitogen- activated 13Y10488AF004709
PRKM3Protein kinase, mitogen-activated 3 (MAP kinase 3; p44)M84490, Z11696X60188
3
PRKM4Protein kinase, mitogen-activated 4 (MAP kinase 4; p63)X59727X59727
1
PRKM6Protein kinase, mitogen-activated 6 (extracellular signal-regulated kinase, p97)L77964, X80692X80692
PRKM7Protein kinase mitogen-activated 7 (MAP kinase)U25278
PRKM8Protein kinase mitogen-activated 8 (MAP kinase)L26318
PRKM9Protein kinase mitogen-activated 9 (MAP kinase)L31951, U34821U09759
2
PRKMK1Protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)L11284L11284
3
PRKMK1Protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)L11284L11284
3
PRKMK2Protein kinase, mitogen-activated, kinase 2, p45 (MAP kinase kinase 2)L11285L11285
4
PRKMK3Protein kinase, mitogen-activated, kinase 3 (MAP kinase kinase 3)D87116, L36719D87116
PRKMK5Protein kinase, mitogen-activated, kinase 5 (MAP kinase kinase 5)U25265U25265
1
PRKMK7Protein kinase, mitogen-activated, kinase 7 (MAP kinase kinase 7)AF022805AF013589
PRKRProtein kinase, interferon-inducible double stranded RNA dependentM35663M35663
PTK2PTK2 protein tyrosine kinase 2L05186
PTK2BProtein tyrosine kinase 2 betaL49207, U33284U43522
PTK7PTK7 protein tyrosine kinase 7U33635, U40271U33635
PTK9Protein tyrosine kinase 9U02680U02680
RAB8IPRab8 interacting protein (GC kinase)U07349U07349
RASA1RAS p21 protein activator (GTPase activating protein) 1M23379M23379
RETRet proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)X15262
RGS1Regulator of G-protein signalling 1S59049, X73427S59049
RGS16Regulator of G-protein signalling 16U70426U70426
RGS7Regulator of G-protein signalling 7U32439U32439
RHO7GTP-binding protein Rho7L78833, X95456U18009
U72882
L78833
Location 1 (2)
Location 2 (2)
Location 3 (1)
RHOKRhodopsin kinaseU63973
ROCK1Rho-associated, coiled-coil containing protein kinase 1U43195U43195
6
RPS6KA2Ribosomal protein S6 kinase, 90kD, polypeptide 2L07598, X85106
RPS6KB1Ribosomal protein S6 kinase, 70kD, polypeptide 1M60724, M60725M60724
RYKRYK receptor-like tyrosine kinaseS59184, X69970S59184
2
SAPK3Stress-activated protein kinase 3U66243, X79483
SERK1SAPK/Erk kinase 1L36870, U17743L36870
SFNStratifinAF029082X57348
SH2D1ASH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)AL023657AL023657
AL022718
1
SH3D1BSH3 domain protein 1BU61167U61167
SRCV-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homologK03218
SRPK2SFRS protein kinase 2U88666U88666
SSI-1JAK binding proteinU88326, AB000676, AB000734, AB005043AB000734
SSI-3STAT induced STAT inhibitor 3AB004904, AB006967AB004904
1
STAT1Signal transducer and activator of transcription 1, 91kDU18662, U18663, U18664, U18665, U18666, U18667, U18668, U18669, U18670
STAT2Signal transducer and activator of transcription 2, 113kDU18671U18671
STAT3Signal transducer and activator of transcription 3 (acute-phase response factor)L29277L29277
STAT4Signal transducer and activator of transcription 4L78440L78440
STAT5ASignal transducer and activator of transcription 5AL41142, U43185, U47686U43185
U47686
STAT6Signal transducer and activator of transcription 6, interleukin-4 inducedAF067572, AF067573
STATI2STAT induced STAT inhibitor-2AB004903, AB006966, AF037989AF037989
1
STK11Serine/threonine kinase 11 (Peutz-Jeghers syndrome)AF032986, AF035625AF032986
STK15Serine/threonine kinase 15D84212, AF008551, AF011467, AF011468AF011468
1
STK17ASerine/threonine kinase 17a (apoptosis-inducing)AB011420AC005189
AB011420
1
STK17BSerine/threonine kinase 17b (apoptosis-inducing)AB011421AB011421
STK2Serine/threonine kinase 2L20321L20321
1
STK3Serine/threonine kinase 3 (Ste20, yeast homolog)U26424U26424
STK4Serine/threonine kinase 4U60207U60207
SUB1.5Guanine nucleotide exchange factor; 115-kD; mouse Lsc homologU64105U64105
SYKSpleen tyrosine kinaseL28824L28824
1
TESK1Testis-specific kinase 1D50863D50863
TIAM1T-cell lymphoma invasion and metastasis 1U16296
TK2Thymidine kinase 2, mitochondrialU77088, Y10498
TNFAIP1Tumor necrosis factor, alpha-induced protein 1 (endothelial)M59465M59465
1
TRKOncogene TRK
TRK1TRNA lysine 1
TTKTTK protein kinaseM86699M86699
TXKTXK tyrosine kinaseL27071L27071
TYK2Tyrosine kinase 2X54637X54637
TYRO3TYRO3 protein tyrosine kinaseU18934U18934
1
TYROBPTYRO protein tyrosine kinase binding proteinAF019563AF019562
2
UBE1LUbiquitin-activating enzyme E1, likeL13852L13852
UBE2AUbiquitin-conjugating enzyme E2A (RAD6 homolog)M74524M74524
1
UBE2BUbiquitin-conjugating enzyme E2B (RAD6 homolog)M74525, X53251M74525
VASPVasodilator-stimulated phosphoproteinZ46389Z46389
2
VAV2Vav 2 oncogeneS76992
VRK2Vaccinia related kinase 2AB000450AB000450
WASWiskott-Aldrich syndrome (ecezema-thrombocytopenia)U12707, U19927U12707
YES1V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1M15990M15990
YESPV-yes-1 Yamaguchi sarcoma viral oncogene homolog pseudogene
ZAP70Zeta-chain (TCR) associated protein kinase (70 kD)L05148
ZPKZipper (leucine) protein kinaseU07358U07358

Michael Edmonson (edmonson@nih.gov)
Generated at Thu Jan 27 15:13:13 2000