Bera O, Cesaire R, Edouard A, Delaunay C, Sobesky G, Neisson-Vernant C; International Conference on AIDS.

Int Conf AIDS. 1993 Jun 6-11; 9: 673 (abstract no. PO-C06-2734).

CHU de Fort-de-France, Martinique-F.W.I.

OBJECTIVES: To determine the prevalence of anti HBV markers and HCV antibodies in a cohort of HIV infected patients from the "hopital de jour" (Internal Medecine outpatient clinic) in Martinique F.W.I. METHODS: 167 sera were collected in 1991-1992 (62% male and 38% female, mean age of 41 years (range: 21/73)). All sera were tested for HCV antibodies utilizing a second generation EIA assay (Abbott) and a confirmatory test. Detection of HBs Antigen, anti HBc Antibodies and anti HBs Antibodies was performed using Abbott ELISA assays. RESULTS: The prevalence of anti HCV found in the cohort was 18% (versus 0.7% in the Martinique blood bank for the same period). Of the 30 patients HCV seropositive: 7/106 (7%) were heterosexuals, 3/31 (10%) homosexuals, 7/9 (78%) transfused patients, 13/16 (81%) drugs and ex-drugs abusers, 0/6 bisexuals. HBs Ag, antiHBs Ab or anti HBc Ab were present in 77% of the HCV+ and 51% of the HCV- patients. Martinique is an endemic area for hepatitis B virus (15% of the blood donors are HBc+). This may explain the small difference in term of HBV markers presence between homosexuals (58%) and heterosexuals (48%). In cohort studied, 8% of the patients were found AgHBs positive: no significant difference was observed between groups, except regarding transfused patients (22%). No patient was found anti-Delta antibodies positive. CONCLUSION: HIV/HCV co-infection can be demonstrated rather frequently in patients with a history of drug abuse and/or blood transfusion. Drugs abusers presented with a very high level of HBV and HCV contamination (94% and 81% respectively). In our study, sexual transmission seems to play an important role for HBV but not HCV contamination. These results are similar to those reported in the literature, the only difference being the heterosexual orientation of the HIV+ population in Martinique.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Biological Markers
• Blood Donors
• Blood Transfusion
• Female
• HIV Infections
• HIV Seropositivity
• Hepacivirus
• Hepatitis B Antibodies
• Hepatitis B Surface Antigens
• Hepatitis B virus
• Hepatitis C Antibodies
• Humans
• Male
• Martinique
• Population
• Population Groups
• Prevalence
• immunology

Other ID:

• 93336656

UI: 102206035

From Meeting Abstracts