Watenpaugh DE, Wasmund WL, Wasmund SL, Muenter NK, Smith ML.
Circulation. 1998; 98: I128.
UNT HSC, Fort Worth, TX, USA.
Many people do not sleep enough. Sometimes people sleep less than normal over several nights. We hypothesized that sleep restriction accentuates autonomic responses to a stressor such as static handgrip exercise to volitional fatigue. Methods: Nine healthy subjects (3 females, 6 males) slept only 4 hours per night for 4 consecutive nights. Before and after sleep restriction, subjects performed static left handgrip endurance tests at 50% of pre-sleep restriction maximal grip strength. On the right (resting) arm, finger photoplethysmography measured arterial blood pressure and heart rate, and ultrasound measured brachial arterial blood flow. As an index of sympathoexcitation, we calculated right forearm vascular resistance (FVR) responses to left static handgrip as mean arterial pressure divided by brachial (forearm) blood flow. Results: Sleep restriction did not affect left handgrip endurance time, and heart rate and arterial pressure responses to handgrip endurance testing also remained unchanged after sleep restriction (all P> 0.2). However, the increase in FVR in the resting forearm during the handgrip endurance test doubled (P = 0.04) from the pre-sleep restriction elevation of 10 +/- 6 units (an 11% increase, X +/- SE) to 21 +/- 4 after sleep restriction (a 23% increase). Also, the reduction in FVR over the first min following the handgrip endurance test equaled 14 +/- 4 units (a 14% reduction) prior to sleep restriction, yet FVR decreased 27 +/- 4 units (a 24% reduction) following the post-sleep restriction handgrip test (pre- vs. post-sleep restriction P = 0.007). Conclusion: These data support our hypothesis that sleep restriction exaggerates sympathetic-mediated vasoconstrictor responses to exercise stress. Therefore, sleep restriction may place individuals with underlying cardiovascular disease at greater risk.
Publication Types:
Keywords:
- Arm
- Blood Pressure
- Exercise
- Female
- Forearm
- Heart Rate
- Humans
- Male
- Sleep
- Sleep Deprivation
- Vascular Resistance
- blood supply
- NASA Discipline Regulatory Physiology
- Non-NASA Center
Other ID:
UI: 102195003
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