| US 7,414,153 B2 | ||
| Process for preparation of optically active 1-erythro-2-amino-1-phenyl-1-propanol | ||
| Subrahmanyam Gollapudy, Hyderabad (India); and Sunil Vaman Joshi, Mahad (India) | ||
| Assigned to Emmellen Biotech Pharmaceuticals Limited, Mumbai (India) | ||
| Appl. No. 11/578,362 PCT Filed Mar. 09, 2005, PCT No. PCT/IN2005/000075 § 371(c)(1), (2), (4) Date Oct. 13, 2006, PCT Pub. No. WO2005/100299, PCT Pub. Date Oct. 27, 2005. |
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| Claims priority of application No. 448/MUM/2004 (IN), filed on Apr. 15, 2004. | ||
| Prior Publication US 2007/0203363 A1, Aug. 30, 2007 | ||
| Int. Cl. C07B 57/00 (2006.01); C07C 209/00 (2006.01) | ||
| U.S. Cl. 564—304 [564/357] | 15 Claims |
| 1. A process for preparation of 1-erythro-2-amino-1-phenyl-1-propanol from 1-1-phenyl-1-hydroxy-2-propanone comprising:
i) reacting 1-1-phenyl-1-hydroxy-2-propanone with an oximation agent in the presence of a base to form 1-1-phenyl-1-hydroxy-2-propanone
oxime
ii) reducing 1-1-phenyl-1-hydroxy-2-propanone oxime using nickel aluminium catalyst mixture as reducing agent
to obtain crude optically active 1-erythro-2-amino-1-phenyl-1-propanol base.
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