Woolley I, Valdez H, Walker C, Landay A, Hess G, Zdunek D, Lederman M; International Conference on Emerging Infectious Diseases.
NLM Gatew. 1998 Mar 8-11; (abstract no. P12.8).
Case Western Reserve University School of Medicine, Cleveland, OH.
OBJECTIVE: To determine the prevalence of hepatitis G virus (HGV) antibody in AIDS patients and determine any relationship to clinical or laboratory abnormalities. To determine any relationship between HGV antibody and plasma HGV PCR. METHODS: Plasma samples from 192 AIDS patients were tested for HGV RNA by RT-PCR and for antibody to a putative HGV envelope protein by ELISA. RESULTS: Of 192 samples 50 (26%) were positive for HGV antibody and 44 of 192 samples (22%) were positive for HGV RNA. Only one sample (0.5%) was positive in both tests. Presence of HGV antibody was not associated with hepatic or hematologic abnormalities, any specific HIV risk group, AIDS related opportunistic infection or plasma HIV RNA levels. The mean CD4+ count in persons with evidence of past or present HGV infection by antibody or PCR was lower than that of those without evidence of infection (105 cells/uL v. 153 cells/uL, p less than 0.05). CONCLUSIONS: HGV exposure is common in AIDS patients in Cleveland. The clinical manifestations of HGV in this population are not recognized. HGV antibody may be protective against HGV propagation in this population.
Publication Types:
Keywords:
- AIDS-Related Opportunistic Infections
- Acquired Immunodeficiency Syndrome
- Antibodies
- CD4 Lymphocyte Count
- Communicable Diseases
- Enzyme-Linked Immunosorbent Assay
- GB virus C
- HIV Infections
- Humans
- Prevalence
- Reverse Transcriptase Polymerase Chain Reaction
Other ID:
UI: 102236447
From Meeting Abstracts