The DOMON
domains are involved in heme and sugar recognition
MULTIPLE SEQUENCE ALIGNMENT OF THE DM13 DOMAIN
Secondary
Structure
------------------EEEEEEE------EEEEEE-------------EEEEEE------------EEEE-----EEE
WH5701_02499_Syn_87301508 35 GMF------QKAEAP-VSGSFMIKTEAGKQ-VLVLSSDFKTND---SAPDLKVAFSPSAKPLAMSKPPKYELKAGSYTVL
MED121_19319_Msp_87121730 29 GELEADFS-SWGSDA-VEGDWRISERGGKQ-YIQLLDNFEAK----EGPDVKIFLSKQDAASVNG-----NNATDDAVFI
SAV0708_Saur_15923698 54 GTFS-----SKNGET-VEGKAEIKN------GKLMLTNYKSS----KGPDLYVYLTKNG-----------DIKNGKEIAM
Tery_2225_Tery_113475866 104 GKFVT----VTRGEN-TKGRAEIIRVGGKT-QVRLGENFSTM----VGPAVKLVLHKQSRPESYT--------GENYVPL
SAR0761_Saur_49482964 54 GTFS-----SKNGET-VEGKAEIKN------GKLMLTNYKSS----KGPDLYVYLTKNG-----------DIKNGKEIAM
Dpse\GA17202_Dpse_54637920 149
PRPQKISAL-RGVHG-VSSENIVIVDA----QTLLVPNFSYDG---EAPDAKFWVGRGQRPTSEG-----LRIPDENGKE
LOC579039_Spur_115695230 93 GALGFS----PLVHR-TSAAAVVVLDP----KKIRFEDLNYDG---FGPDAYFWVGPGDTPSYDE----DYRIPDETGSL
Npun02007944_Npun_53686863 49 GTF------VSGEQK-TQGKVNITTKDGKS-FLELDESFKTSE---SGPDLVVILHRSDNVINSTKPPSYPLKNGDYFII
VV2_0813_Vvul_27367221 60 GEFSRDRADSDFLHW-GEGKLVIDAQ-----SIAFLGELA------PGPDYKLYLSPTFIETEAD----FLANKEQLVRV
PTD2_04781_Ptun_88861382 53 AKFERHLQDSDFLHF-GEGEVFISQH-----AIAFVGTLA------PGPDYQLYLSPEFVETELD----FNRLKAQMVQV
SKA34_10313_Psp_89075712 53 GVFKKDLAGSDFLHW-GEGKVSISTT-----KITLMGKLA------PGPDYKLYLSPRFVETEAE----FNQEKADMVLV
VAS14_13564_Vang_90578082 53 AEFKRDLAGSDFLHW-GEGKVSISPT-----KITLMGKLA------PGPDYKLYLSSKFVETETE----FNQEKTNMVLV
SwooDRAFT_1484_Swoo_118072177 53 GQFSRERADSDLLHW-GEGEVSISAD-----SIAFIGSLA------PGPDYRLYLSPKFVDTESG----FNRLKPSMVQV
GP2143_05890_Mgam_119476097 53 GVFSRDRTDSDTLHW-GEGDVAIGVS-----SIAFVGSLA------PGPDYKLYLSPEYVETESA----FIRLKPSMVQV
AHA_0124_Ahyd_117618213 53 GTFRRDLQDSDRLHW-GEGQVSIGPD-----AISLMGKLA------PGPDYQLYLSPVFVETEAD----FARLKEKMVKI
Bpro_4776_Psp_91790601 51 GQFRRDLKDSDPLHW-GEGTVSVSPQ-----SIALSGKLA------PGPDYKLYLSPEFVETEAD----FARLKARMTRV
Rgel02001255_Rgel_47574394 50 AQFRRELKDSDALHW-GEGMVFVGPR-----SISLLGRLA------PGPDYKLYLSPEFVETEAD----FQRLKPQMLRV
_Apre_3056881 85 GGF------VTQEHE-TRGTATVLRNGAA--RVLRLEGFSTS----DGPDLHIWLSDATAGGEWG-----KYDDGRYLPL
Bcep18194_B2454_Bsp_78063301 52 SRFERDLPGSDALHW-ADGKLTITDS-----SIAFEGDIA------PGPDYKIYLVPEFVDTRAS----FLAIKARAARV
BURPS1710b_A0229_Bpse_76818639 51 GRFERSLTRGDPLHW-TDGKLSVTRA-----ALAFEGRVA------PGPDYKLYLVPGFVASKEA----FLAAKPHARRV
BMAA1071_Bmal_53716672 51 GRFERSLTRGDPLHW-TDGKLSVTRA-----ALAFEGRVA------PGPDYKLYLVPGFVASKEA----FLAAKPHARRV
BTH_II1180_Btha_83716796 51 GRFERGLTGGDPLHW-TDGKLSVTRA-----ALAFEGRVA------PGPDYKIYLVPEFVASKQA----FLDVKSRARRV
Dpse\GA17202_Dpse_54637920 34 GTKIGAL--TRLHHG-VSGDVYAVDS-----RTIFIKKFSYDG---EAPAAYFYVGNTARPSNEG----ATRLRDERGGT
VVA1277_Vvul_37676937 67 GEFSRDRADSDFLHW-GEGKLVIDAQ-----SIAFSGELA------PGPDYKLYLSPTFIETEAD----FLANKERLVRV
MED92_12219_Osp_89095454 51 GTFTKDLPGSDFLHW-GEGKLSLSQN-----KIVFEGELA------PGPDYKLYLSPVFVDDEAS----FEASKAKMVQL
y4083_Ypes_22127952 53 GEFSRNQKGSDAVHW-AEGKLYVSEH-----EIAFEGEIA------PGPDYKIYLTKTQADDKES----FLKIKDDAKLI
CPS_0108_Cpsy_71281863 208 GFF------STFAHN-VSGKATIIDD-----CTIEISQFSYDG---GGPDVYFYGAIDHEYTSVD------AFPMGQKLN
BCE_G9241_pBC218_0022_Bcer_47565260 59 GQF------QNGTHE-TTGTAKIHQFADGK-RVLRLSDFATS----NGPDVRVVLVPTNHLKNNE-----DVKNYKYIEL
BcerKBAB4DRAFT_5400_Bwei_89204057 61 GQF------QNGVHE-TTGTATIHQLADGK-RILRLSNFSTS----NGPDVRVVLVPTDRLKNNE-----DVKNHQYIEL
h16_B2146_Reut_116696082 56 GTFRKDLAGSDALHW-ASGQLHVSPQ-----ALAFEGSVA------PGPDYRIYLAPEFVDNKEA----FLRIKDRSLQV
StropDRAFT_2984_Stro_113943736 94 GEF------ITHEHN-TSGTARIIRTAD---GTLRLELVGLATS--NGPDLRVWLTDQPVRTGEAGW--HVFDDGHWVEL
V12B01_16186_Vspl_84385226 50 GEFTKDRQDSDFLHW-GEGIVSVSES-----AIAFEGELA------PGPDYKVYLSPKFIETEQA----FNDSKSELLRV
MED222_03785_Vsp_86145746 50 GEFTKDRQDSDFLHW-GEGIVSVSES-----AIAFEGELA------PGPDYKVYLSPKFIETEQA----FNDSKSELLRV
DIP1688_Cdip_38234259 79 GQF------ISHEHE-TSGTATLIVDADGK-KKLVLTDLATS----NGPDVHVWLSKAPVIPGKDGW--FVAKDHEHFDV
ELI_07270_Elit_85374281 9 GQFRG----ADSSHP-ASGGVEIVKLKGGGLGVKLKGDFKVR----GGPDLRVWLSDASNPRNGR-----AVRSKDYVDL
CENSYa_0388_Csym_118194106 174 GSFA-----GLAGHA-ADGDAKILDVSGT--RFLRFENFEVT----NGPDLRVYLAPDGSVSQGI-------------EL
FP2506_10116_Fpel_114705286 30 GRFT-----GAGGHV-ASGTVTVVTENGRT-RVVFGNDFSLD----SAPDAYVAFGSARSYAEGT-------------AF
SPO3881_Sipo_56698692 31 GHFE-----GRSNHV-TSGSVKLVKDGERY-VVELGDDFSLD----GGPDPRVAFGKDGKYDPDT-------------KL
pFBAOT6.58_Apun_51492571 51 GRLARDLKGSDLLHW-GEGEIRVSRD-----RIAHIGRLA------PGPDYKLYLAPRFVDTKEA----FLLIKDRSVRV
RS9917_09446_Syn_87123823 48 GRF------LAAEHP-AAGQVHLERRNGNA-TLVFSQDFRTTD---QAPDLFVVVSPMAMPLENSPAPAYPLTPGTFHVV
alr1534_Ana_17229026 41 GNF------QAGEHP-TQGQVSVVKEAGKN-YLEFDRNFKTD----QGPDLYVILYRFEKPPISG------IKEKDYVSI
Shewana3_4340_Ssp_117676277 53 GEFKKDQKGSDALHW-ANGQLFVTDN-----EIVFKGDVA------PGPDYKIYLTKKQATDKES----FLDIKKEAILI
LV102a_Kpne_38639590 57 GDFKRNQKGSDVLHW-AEGELYVTDN-----EIAFKGEVA------PGPDYKIYLTKKQAVDKSS----FLEMKKEAVLI
YPO4064_Ypes_16124178 45 GEFSRNQKGSDAVHW-AEGKLYVSEH-----EIAFEGEIA------PGPDYKIYLTKTQADDKES----FLKIKDDAKLI
YpesA_01002441_Ypes_77634206 49 GEFSRNQKGSDAVHW-AEGKLYVSEH-----EIAFEGEIA------PGPDYKIYLTKTQADDKES----FLKIKDDAKLI
L8106_15844_Lsp_119494581 51 GSFVT----VEQDHP-TEGTARIVNENGKR-YLEFDSAFTTA----QGPDVNIIFHQKNSVPVNL-------KEGEYITL
HaurDRAFT_3840_Haur_113938194 124 GSF------RGIDHK-SGGIATLYQQPDGS-NLLRLSDFFVE----AGPDMYIFVAKAAEINQPS------DLQAGYLEL
CwatDRAFT_1309_Cwat_67924807 35 GSFI-----GQGGHT-VSGEFQIIKKGEIH-YLVLQDNFKFDGA--PDPKIGFSLNDEF--------------SEDTLFS
SAML0205_Samb_91199778 79 GGL------ISHEHA-TSGTVKLVRLTDGS-HVVRLENLDTS----NGPDLHVWLTDAPVKEGTAGW--HVFDDGKYVSL
SCO0153_Scoe_21218710 85 GEL------VSHEHS-TSGTAQLVRLTDGS-HVVRLENLDTS----NGPDVHVWLTDAPVKEGKAGW--HLFDDGEYVDL
_Smob_28864193 87 GTL------ISHEHT-TSGTVRVLRLPDGS-RTLRLEGLDTS----NGPDVKVLLSDAPVKPGRAGW--HVFDDGAHVSL
Sde_3314_Sdeg_90022954 232 AEF------NTFAYG-VAGTVTVVND-----CTLLFTRFSYTGG--GLPDVYFYTGPNGNFNQGS-----GFGPNLYG--
gll1172_Gvio_37520741 132
ETPPLSLVSVDAKTT-GTGRIVVENGKS---YVQLSEDFTIG----EAPAIRMTLYKDAAPPKKT------YDPKKYVDL
MGP2080_04650_Mgam_119504874 66 TEFNRQRKDSDALHW-GEGQLRIYAD-----AIIFEGNLA------PGPDYRLYLAPKFVETEAD----FLAVKEQSVEI
Dpse\GA11661_Dpse_54638383 35
KPRVLPEFK-RLAHGLRSSNISVLDA-----KTFYIPNLHYDG---AGPDAYFWVGNGSEPNIMG-----IKVPNEVGSL
Jann_4076_Jsp_89056567 31 AIASGQFQD-TGPRYQGSGSAVIAQTSDGQ-TVLQFGDFSVT----PGPDLEVWLVEADAPTSAA-----AVLASSYISL
AgaP_ENSANGG00000002671_Agam_118777513 4 GREIGHL--TNFGHG-IKGQVFAVDE-----STLFVKGFAYDG---NAPDAFFWVGNSPRPSPEGF---IIPYPEEYSGR
CG32922_Dmel_33589346 34 GTKIGAL--TRLHHG-VSGDVYAVDS-----RTIFIKKFNYDG---EAPAAYFYVGNTARPSNEG----AARLRDERGGT
CG14681_Dmel_78706736 34 GTKIGAL--TRLHHG-VSGDVYAVDS-----RTIFIKKFNYDG---EAPAAYFYVGNTARPSNEGA----ARLRDERGGT
LOC657143_Tcas_91093736 56 GKFIGKL--SELHHG-VSGEVYAVDG-----RTLYLKDFTYDG---QGPAAYFYASTSRNANSAG-----FRLRDENGSP
CG14681_Dmel_78706738 34 GTKIGAL--TRLHHG-VSGDVYAVDS-----RTIFIKKFNYDG---EAPAAYFYVGNTARPSNEGA----ARLRDERGGT
LOC579354_Spur_115712036 28 GKLVGTFT-DKSTHD-IAGTVYAEDE-----TTLRIIGFRYDG---AGPDAFIWAGESGVPSDDG-----FIIPDEEGRT
LOC759839_Spur_115740301 10 GKLVGTFT-DKSTHD-IAGTVYAEDE-----TTLRIIGFRYDG---AGPDAFIWAGESGVPSDDG-----FIIPDEEGRT
LOC575280_Spur_115894476 29 GEFIQQGDTPATHHN-VNGTVYAVDD-----DTLQIIGFTFDG---KAPDTFFFIGTSGTPSGNS------YVIPKAIGL
AgaP_ENSANGG00000007940_Agam_58384351 33 GTKIGDL--SELHHG-VSGSVYAVDA-----RTLFLKNFNYDG---EGPAAYFYVGNTRAPSNKG----AHRLRDERGRA
LOC756575_Spur_115749019 12 GKLVGTFT-DKSSHD-IAGTVYAEDD-----TTLRIIGFRYDG---AGPVAYFWVGPGGTPNNNGD----YAIPDETGST
LOC661990_Tcas_91089939 57 GRLIGPL--QEFAHG-IKGTVYAVDE-----STIFIKGFSYDG---TGPDAFFWIGNSPRPSPEGI---IIPYPENYAGR
LOC766813_Spur_115616851 17 GEFIQQGDTPATHHN-VSGTVYAVDD-----DTLQIIGFTFDG---KAPDTFFFIGTTGTPSGNG------YVIPKAIGL
AgaP_ENSANGG00000012956_Agam_58375727 4 GKYIGKF--NSYHHQ-ASGDVYAVDE-----YTFLLTGFNYDG---NGIDTFFWSGASNRPGPQG-----FIVPDEYGKT
AgaP_ENSANGG00000003130_Agam_118784555 4 GKYIGKF--NSYHHQ-ASGDVYAVDE-----YTFLLTGFNYDG---NGIDTFFWSGASNRPGPQG-----FIVPDEYGKT
knk_Dmel_21356127 43 GKYLGKL--NSYHHQ-VSGDVYAVNE-----YTFLIVGFNYDG---NGADTFFWSGASNRPGPQG-----FIVPDEYGKT
W01C8.5_Cele_17570215 148 SVKLSTEFS-GKRYQLRSGPLYVIDR-----RTIKVYGFTFEGN--KAPKTYFYAGRGASVSYSSGVKVAIRGKDEKEIS
CBG14733_Cbri_39598096 146 SVALNSEFT-GKRYKLRSGPLYVIDR-----RTIKVYGFTFEGN--KAPKTYFYVGRGASVSYSLGVKVAIRGKDEKEIS
CBG07437_Cbri_39596518 230
FESEPDMGL-FGEYGIISDPIEVIDS-----RTLRIPRFSYKAS--QTPDGYFFAGAGKDIDTKTGEKAVIVGKDLSVNT
H06A10.1_Cele_17568459 148
FESEADMGL-FGEYGIISDPIEVIDS-----RTLKIPKFSYKAS--QTPDGYFFAGAGSEIDQKSGKKAAILRSDQTLNY
LOC661990_Tcas_91089939 176 PRVLPEFK--RLAHGLRSDNISILDA-----KTFYIPNLHYDG---AGPDAYFWVGNGSEPSPFG-----IKVPNEMGSL
AgaP_ENSANGG00000002671_Agam_118777513 123 PRVLPEFK--RLAHGLRSSNISILDA-----KTFYIPNLHYDG---AGPDAYFWVGNGSEPNIMG-----TKVPNELGSL
CG12492_Dmel_24649429 35
KPRVLPEFK-RLAHGLRSSNISVLDA-----KTFYIPNLHYDG---AGPDAYFWVGNGSEPNIMG-----IKVPNESGSL
AgaP_ENSANGG00000007940_Agam_58384351 149 PTKIAGL---SGVHDVSSDNIVIVDA-----QTLLVPNFSYDG---EAPDAKFWVGRGPAPTSQG-----IRIPDENGKE
CG32922_Dmel_33589346 149
PRPQKISAL-RGVHGVSSDNIVIVDA-----QTLLVPNFSYDG---EAPDAKFWVGRGQRPTSDG-----LRIPDENGKE
CG14681_Dmel_78706738 149
PRPQKISAL-RGVHGVSSDNIVIVDA-----QTLLVPNFSYDG---EAPDAKFWVGRGQRPTSDG-----LRIPDENGKE
LOC575280_Spur_115894476 154 GRLGLS----PVVHGVTAEDVIILNS-----KLIRFVGLNYDG---RGPDAYFWTDTVTNPTTSG-----MRVPQDGERT
LOC766813_Spur_115616851 142 GRLGLS----PVVHGVTAEDVIILNS-----KLIRFVGLNYDG---RGPDAYFWTDIVTNPTTNG-----MRVPQDGERT
LOC763595_Spur_115784194 21 GQL-------SGSYGLSATSVVIVND-----QKLRFEGLQYDG---SCSGARFWAGTGSTPSSSG-----HFVRNEHNSD
LOC578503_Spur_115753700 54 GFGPALGFS-PRVHGTSATAVVVLDP-----KKIRFENLNYDG---LGPDAYFWVGPGDTPNNDGD----YKIPDETGSL
LOC657143_Tcas_91093736 169
PKPQKIEPL-KGVHAISSDPIVIVDA-----QTLLVPNLSYDG---EAPDAKFWVGRGPKPSPQG-----IRVPDENGKM
LOC759839_Spur_115740301 130 GALGFA----PRVHNTYASAVIILNA-----KQIRVENLVYDG---QGPRAYFWVGPGGTPNNDGD----YEIPDETGST
LOC579354_Spur_115712036 148 GTLGFT----PRVHNTYASAVIILNA-----KQIRVENLVYDG---QGPRAFFWVGPEGTPNNNGD----YAIPDETGST
knk_Dmel_21356127 162 GTFS------KRSHNVSSSSVEILDS-----KTIRIKDFTYDG---RGKRTFFWTGVGPQPSSRG-----SKLPDERGYL
AT5G54830_Atha_15239759 32 SLIGHESEF-KMLQHQLRGVFTVVDD-----CSFRVSRFDML----SGSEVHWWGAMSSDFDNMT--------NDGFVIS
AgaP_ENSANGG00000012956_Agam_58375727 123 GSLTAI----AGGPMVSSDTIDILDS-----KTIRITDFSYDGKAGGQGAVHFWVGVGPSPSSKG-----SKVPDEMGYL
AgaP_ENSANGG00000003130_Agam_118784555 123 GSLTAI----AGGPMVSSDTIDILDS-----KTIRITDFSYDGKAGGQGAVHFWVGVGPSPSSKG-----SKVPDEMGYL
W01C8.5_Cele_17570215 31 GVYVGDL---SSPETDISGQVFIVNA-----TTLQIFNLTFSP---SQQDLYFWLDTKDVPTREG-----IKAHTFEYGI
Consensus/80% u.h.......p..a..spuph.h.p........hb..ph........uPDhbhhhs.....s..s..........p....
Secondary
Structure
EEE---EE----EEEEE-------------EEEEEEEE------EE---
WH5701_02499_Syn_87301508 APL---KSSKGAQRYVIPASI---DLSKQKSVLIWCQKFNATMAWAPIQ 146\Prokaryotic DM13
MED121_19319_Msp_87121730 SLV---STFEGGSEYEIPAGI---NLNSFKSLIFHCEAYSKLWGTSQIR 139| homologs
SAV0708_Saur_15923698 VD-----YDKEKQTFDL-KNV---DLSKYDEVTIYCKKAHVIFGGAKLK 146|
Tery_2225_Tery_113475866 GDL---KSFTGEQVYNIPEGI---SWQDFPNVVVWCERFDVTFGSAKLN 208|
SAR0761_Saur_49482964 VD-----YDKEKQTFDL-KNV---DLSKYDEVTIYCKKAHVIFGGAKLK 146|
Dpse\GA17202_Dpse_54637920 NPLR--RYERKTIVLTLPEDL---TIFDIGHFGVWCEAFTVDFGHVRLP 258|
LOC579039_Spur_115695230 QVIR--SYSGATVTVTLIDNI---TIADIGHIGLWCVRFRQDFGHVDIP 200|
Npun02007944_Npun_53686863 APL---QKYSGAQTYSIPQNI---NLADYKSAAIWCRKFNATFGAASLS 160|
VV2_0813_Vvul_27367221 GD----VKTFDRFILPIPSDV---DVANYTTAIVWCETFSQFITSAKYR 165|
PTD2_04781_Ptun_88861382 GA----VKTFNNFLVALPAHI---DPTHYNTVIVWCDSFNQFITSAQYQ 158|
SKA34_10313_Psp_89075712 GN----VKTFDNFVVNVPQNI---DIAKYDTVIVWCESFGQFITSAKYQ 158|
VAS14_13564_Vang_90578082 GN----VKTFDNFVVNVPQNI---DIAKYDTVIVWCESFGQFITSAKYK 158|
SwooDRAFT_1484_Swoo_118072177 GS----VNTFDNFIVTIPDDV---DPSHYNTLVVWCESFGQFITSGTYE 158|
GP2143_05890_Mgam_119476097 GD----VKTFDNFLVTMPAGV---DVSQYNAVIIWCETFGQFITSARYQ 158|
AHA_0124_Ahyd_117618213 GP----VKTFDNFIVPLPADV---NPADYDSVIIWCETFGQFITAARYR 158|
Bpro_4776_Psp_91790601 GD----VKTFENFVVRVPESV---DISRYNTVIVWCESFSQFITAARYR 156|
Rgel02001255_Rgel_47574394 GD----VKTFENFLVPVPQGV---DPSRFNTVIVWCEAFGQFITAAKYR 155|
_Apre_3056881 GPM---KATDGNQNYPIPEDA---DLSGLRSVVVWCDRFNVAFGSAPLD 189|
Bcep18194_B2454_Bsp_78063301 AD----LKTFGNFVVPLPADV---NPAQYTSVVIWCERFSKFISAARYR 157|
BURPS1710b_A0229_Bpse_76818639 GE----LKTFGDFVAPLAADV---DIDAYTTVVIWCERFSQFIGAAQYR 156|
BMAA1071_Bmal_53716672 GE----LKTFGDFVAPLAADV---DIDAYTTVVIWCERFSQFIGAAQYR 156|
BTH_II1180_Btha_83716796 GE----LKTFGDFVVPLAEDV---DVDAYTTVVIWCERFSQFIGAARYR 156|
Dpse\GA17202_Dpse_54637920 ASLT-RRYRNKDITLSLPEGK---TLRDIKWFSVWCDEFAVNFGDVAIP 143|
VVA1277_Vvul_37676937 GD----VKTFDRFILPIPSDV---DVANYTTAIVWCETFSQFITSAKYR 172|
MED92_12219_Osp_89095454 SD----VKTFNGFVVNVPEGI---DVGQYTTAVVWCETFAEFISAAKYQ 156|
y4083_Ypes_22127952 GD----LKNFGNFKKTLPAGV---NPDDYTTVQIWCETFSQFIGSASYK 158|
CPS_0108_Cpsy_71281863 GK----IYNNARIFIKLPQNK---SLDDLNGLSVWCTEFEANFGQVEFT 308|
BCE_G9241_pBC218_0022_Bcer_47565260 GN---LKGNKGDQNYEIPEGV---DVSEYGSVSVWCKRFNENFGAVYFN 164|
BcerKBAB4DRAFT_5400_Bwei_89204057 GK---LKGNKGNQNYEIPEGI---DVSTYGSVSVWCKRFNENFGAAYFK 166|
h16_B2146_Reut_116696082 GE----LKTFGNFTVALPAGV---DPARYGAVVIWCERFGQFIGAAGYR 161|
StropDRAFT_2984_Stro_113943736 GR---LKGNRGDQAYDIPAEV---DLDRLTSVSIWCKRFAVSFGAAPLA 202|
V12B01_16186_Vspl_84385226 GD----VKTFDRFMVELPEGT---DLNRFNTVVIWCETFGQFITSAKIK 155|
MED222_03785_Vsp_86145746 GD----VKTFDRFMVNLPEGT---DLNRFNTVVIWCETFGQFITSAKIK 155|
DIP1688_Cdip_38234259 AP---IKGNIGNQVYDLPDDV---NFDEWTSVVLWCDDFNVSFGAAELS 187|
ELI_07270_Elit_85374281 GR---LKSSSGEQIYRIPASA---DVADANSVVIWCRAFGVFFGSATLK 117|
CENSYa_0388_Csym_118194106 GK---LKGSRGSQNYNI-DGI---DTDVYNTVVIYCQPFRVYFGEAQLF 270|
FP2506_10116_Fpel_114705286 AE---LKSLSGGQTYSAPASI---DGSDYDAVWLWCRRFSVPLGVARLR 128|
SPO3881_Sipo_56698692 GA---LLSLTGKQRYAVPPTW---DVSAYNEVYIWCDVAGVPLGVAKIN 129|
pFBAOT6.58_Apun_51492571 GD----VKTFNGFIVEVPAGI---DVRDYNTVVIWCEAFDQFISAAEYQ 156|
RS9917_09446_Syn_87123823 AP---LKSTRGSQRYGLPAYL---KTSEQRSVLIWCRQYNATMSWAQLE 159|
alr1534_Ana_17229026 AQ---LQKITGNQRYALPNNV---NLQEFKSVAIWCRKFNATFGYAIL- 144|
Shewana3_4340_Ssp_117676277 GE----LKNFGNFKKTIPASV---NVNEFTTVQIWCEHFSKFIGSAKYQ 158|
LV102a_Kpne_38639590 GE----LKNFGNFRKSIPDSV---NVNEFTTVQIWCERFSKFIGSAEYR 162|
YPO4064_Ypes_16124178 GD----LKNFGNFKKTLPAGV---NPDDYTTVQIWCETFSQFIGSASYK 150|
YpesA_01002441_Ypes_77634206 GD----LKNFGNFKKTLPAGV---NPDDYTTVQIWCETFSQFIGSASYK 154|
L8106_15844_Lsp_119494581 TS---LQSFEGSQRYLLPDNL---DLSQYKSVGIWCRKFNVTFGYASL- 155|
HaurDRAFT_3840_Haur_113938194 GK---LKGSEGNQNYSLPADF---DPALYANVVIWCEKYQVLMAVAPIQ 228|
CwatDRAFT_1309_Cwat_67924807 GL----NLDQGKQIYRLPFDF---NPDKYNEVTLWCDKFNADLAEAKY- 132|
SAML0205_Samb_91199778 GK---LKGNKGSQNYRVPGDV---DPTRYTSVSIWCDRFDVSFGAAELA 187|
SCO0153_Scoe_21218710 GK---LKGNKGSQNYDVPADV---DPSRYTSVSVWCDRFNVSFGAAELA 193|
_Smob_28864193 GS---LKGNKGDQNYALPRDL---DLDRYTSVSIWCDRFDVSFGASALM 195|
Sde_3314_Sdeg_90022954 -----QTFETTTHIQTISSS----ALNELDAISVWCVQAGVDFGSGVFN 330|
gll1172_Gvio_37520741 G---ALVSRKGDQRYAIPTNL---NVKDYGSIAIWCKKFDVTLAYAKID 240|
Jann_4076_Jsp_89056567 GP---LQSATGGQTYGIPSDI---DASAYGSVVIWCEDFSVLFSVAPLR 142|
MGP2080_04650_Mgam_119504874 GA----VRNFDGFVLSHSPAI---NAAQYTTAVVWCETFGQFITSGQYR 171/
Dpse\GA11661_Dpse_54638383 EP--LRGYQGEDIEIQLPGSM---TVYDIDWLAVWCVEYRHNFGHVYIP 144
AgaP_ENSANGG00000002671_Agam_118777513 EPPVLQQHTNTDIILKLPMGK---RIRDIRWLSVWCRRFTVDFGEIFIP 115
CG32922_Dmel_33589346 ASL-TRRYRNKDVTLSLPEGK---TLRDIKWFSVWCDEFAVNFSDVSIP 143
CG14681_Dmel_78706736 ASL-TRRYRNKDVTLSLPEGK---TLRDIKWFSVWCDEFAVNFGDVSIP 143
LOC657143_Tcas_91093736 EV--IRRYRKEGVTLTLPEGK---TLNNIKIFYVWCEEFEVNFGDVKIP 163
CG14681_Dmel_78706738 ASL-TRRYRNKDVTLSLPEGK---TLRDIKWFSVWCDEFAVNFGDVSIP 143
LOC579354_Spur_115712036 VK--LEAYDNVDIRVTLPAGK---TVSSLAWISVWCREFGANFGDLTVP 136
LOC759839_Spur_115740301 VK--LEAYDNVNISVTLPAGK---TVSSLAWISVWCRQFAANFGDLTVP 118
LOC575280_Spur_115894476 GSEKLGAYSNEDLTIHLDTSEGPGSLSDYLWISVWCKQAGANFADVTIP 142
AgaP_ENSANGG00000007940_Agam_58384351 GV--LRRYRNEDITLSLPEGK---TLRDIRWFSVWCDDFSVNFGDVQIR 141
LOC756575_Spur_115749019 GV--ISAYTGETITLTFPEGT---DIFDIGHFGLWCVQANQDFGHVDIP 121
LOC661990_Tcas_91089939 EPPVLRAYNNTNIILRLPMGK---RIRDIRWLSVWCRRFTVDFGEVFIP 168
LOC766813_Spur_115616851 GSEKLGAYSNEDLTIHLDTSEGPGSLSDYLWISVWCKQAGANFADVTIP 130
AgaP_ENSANGG00000012956_Agam_58375727 NI--LERYFNKDFTLRLPDNK---KITEVKWLAVYDLNSQNNFADVYIP 111
AgaP_ENSANGG00000003130_Agam_118784555 NI--LERYFNKDFTLRLPDNK---KITEVKWLAVYDLNSQNNFADVYIP 111
knk_Dmel_21356127 NI--LDRYHNKDFTLTLPDRK---KITEIKWLAVYDLSSQNNFGDVYIP 150
W01C8.5_Cele_17570215 EIS-ENYRGGKDIILELPENY---DIFHIDWISVYCYKYRVNFGSVLVP 264
CBG14733_Cbri_39598096 EIS-ENYRGGKDIILELPENY---DIFHIDWISVYCYKYRVNFGSVLVP 262
CBG07437_Cbri_39596518 CPM-LKDITDETMIVRLDPSQ---TIYDIEWISVFCYKYSHDFGHLDIG 346
H06A10.1_Cele_17568459 CPM-LKDITDQDIIIRLDQSQ---TIYDIEWISVFCYKYSHDFGHLDMG 264
LOC661990_Tcas_91089939 DP--LRGYQGEDIEIQLPGSI---TVYDIDWLAVWCVQYRHNFGHVIIP 284
AgaP_ENSANGG00000002671_Agam_118777513 DP--LRGYQGEDIEIQLPGNL---TVYDIDWLAVWCVEYRHNFGHVYIP 231
CG12492_Dmel_24649429 EP--LRGYQGEDIEIQLPESL---TVYDIDWLAVWCVEYRHNFGHVYIP 144
AgaP_ENSANGG00000007940_Agam_58384351 TP--LRRYDKKTIVLTLPGDL---TVFDIGHFGVWCEAFTVDFGHVRIP 256
CG32922_Dmel_33589346 NP--LRRYERKTIVLTLPEDL---TIFDIGHFGVWCEAFTVDFGHVRLP 258
CG14681_Dmel_78706738 NP--LRRYERKTIVLTLPEDL---TIFDIGHFGVWCEAFTVDFGHVRLP 258
LOC575280_Spur_115894476 ASKLNQPLSGVTRTVRLPG-----DVFELRSIGLWCVLARQNFGHVVIP 260
LOC766813_Spur_115616851 ASKLNQRLSGVTRTVRLPG-----DVFDKRSIGLWCVLARQNFGHVVIP 248
LOC763595_Spur_115784194 DP-LVAYSGDSDIELILPDGE---SVFEIGYIGVWCQ--GADVGHVDIP 123
LOC578503_Spur_115753700 QI--IKSYSGVNVTVTLLDNI---TVADIGHIGLWCVLFTEDFGHVDIP 164
LOC657143_Tcas_91093736 EP--LRRYDRKTVVLTLPGDL---TVFDIGHFGIWCEAFTVDFGHVQIP 278
LOC759839_Spur_115740301 GV--INPYNGETITLTFPEGT---DIFDIGHFGLWCIRFTQDFGHVDIP 237
LOC579354_Spur_115712036 GV--ISAYNGETITLTFPEGT---DIFDIGHFGLWCIAFTQDFGHVDIP 255
knk_Dmel_21356127 DP--IRQYNKETIELELPGDK---TIFDIDWISVYDVADNENYGHVLFN 266
AT5G54830_Atha_15239759 DQKLNQTFKNSSFIVRLLGNV---TWDKLGVVSVWDLPTASDFGHVLLS 139
AgaP_ENSANGG00000012956_Agam_58375727 DP--IRAYDRETITLELPGDM---TIFDIDWFSVYDVEARRDYGSILIS 232
AgaP_ENSANGG00000003130_Agam_118784555 DP--IRAYDRETITLELPGDM---TIFDIDWFSVYDVEARRDYGSILIS 232
W01C8.5_Cele_17570215 TPLGSFPEDNDRVVVHVPEKH---RIDEFKSFSIYSFKTDKSMASVVFP 140
Consensus/80% s.......p..sb.h.hP.s....sh.ph..hshhC.ph...hu.s.h…...
Supplementary
Fig. 2. Multiple
alignment of the DM13 domain.
Proteins are represented by their gene names, species abbreviations and gis. The
coloring reflects the consensus at 80% conservation. The consensus abbreviations and corresponding
coloring scheme is as follows: a, aromatic (FYWH) and h, hydrophobic residues
(ACFILMVWY), shaded yellow; s, small residues (AGSVCDN), colored green; u, tiny
residues (GAS) shaded green; b, big residues (EFHIKLMQRWY), shaded grey; and p,
polar residues (CDEHKNQRST) colored blue. The nearly absolutely conserved
cysteine is shaded red. Species abbreviations are as follows: Prokaryotes: Ahyd : Aeromonas hydrophila; Ana : Nostoc
sp.; Apre : Actinosynnema pretiosum;
Apun : Aeromonas punctata; Bcer : Bacillus cereus; Bmal : Burkholderia mallei; Bpse : Burkholderia pseudomallei; Bsp. : Burkholderia sp.; Btha : Burkholderia thailandensis; Bwei : Bacillus weihenstephanensis; Cdip : Corynebacterium diphtheriae; Cpsy : Colwellia psychrerythraea; Csym : Cenarchaeum symbiosum; Cwat : Crocosphaera watsonii; Elit : Erythrobacter litoralis; Fpel : Fulvimarina pelagi; Gvio : Gloeobacter violaceus; Haur : Herpetosiphon aurantiacus; Jsp. : Jannaschia sp.; Kpne : Klebsiella pneumoniae; Lsp. : Lyngbya sp.; Mgam : marine gamma; Msp. :
Marinomonas sp.; Npun : Nostoc punctiforme; Osp. : Oceanospirillum
sp.; Psp. : Photobacterium sp.; Psp.
: Polaromonas sp.; Ptun : Pseudoalteromonas tunicata; Reut : Ralstonia
eutropha; Rgel : Rubrivivax gelatinosus;
Samb : Streptomyces ambofaciens; Saur : Staphylococcus aureus;
Scoe : Streptomyces coelicolor; Sdeg : Saccharophagus degradans;
Sipo : Silicibacter pomeroyi; Smob : Streptomyces mobaraensis;
Ssp. : Shewanella sp.; Stro : Salinispora tropica; Swoo : Shewanella
woodyi; Syn : Synechococcus sp.; Tery : Trichodesmium
erythraeum; Vang : Vibrio angustum; Vsp. : Vibrio sp.;
Vspl : Vibrio splendidus; Vvul : Vibrio
vulnificus; Ypes : Yersinia pestis. Eukaryotes: :Agam : Anopheles
gambiae; Atha : Arabidopsis thaliana;
Cbri : Caenorhabditis briggsae; Cele
: Caenorhabditis elegans; Dmel : Drosophila melanogaster; Dpse : Drosophila pseudoobscura; Spur : Strongylocentrotus purpuratus; Tcas : Tribolium
castaneum.