Bissuel F, Cotte L, Pere-Verge D, Bailly F, De Monclos M, Vitrey D, Trepo C; International Conference on AIDS.
Int Conf AIDS. 1998; 12: 542 (abstract no. 32109).
Liver and AIDS Unit, Hotel-Dieu Hospital, Lyon, France.
OBJECTIVE: To evaluate the prevalence of Helicobacter pylori (HP) in HIV-infected patients, which is a major etiologic agent of upper gastrointestinal symptoms in HIV-negative individuals. METHODS: From July 1994 to May 1996, we conducted a prospective study in HIV-infected patients who underwent upper endoscopy in our unit. Antral and duodenal biopsies were systematically performed. HP infection was diagnosed by identification of the organism on histology (Giemsa staining), culture, or positive urease testing (CLO-test). RESULTS: 81 patients were studied (73 male, 8 female): 38 homosexuals, 15 intravenous drug addicts, 14 heterosexuals, 2 blood transfused. 63 patients belong to CDC stage C. Mean CD4 count was 92/mm3 (0-928). 45 patients had an antiretroviral therapy including one or two nucleoside analogues. Endoscopy was performed within a context of diarrhea in 26 patients, weight loss in 22, dysphagia in 16, abdominal pain in 15, and anorexia in 2. A total of 27 patients (33%) were positive for HP (HP+). Endoscopy was macroscopicaly and histologicaly abnormal in 70 patients: gastric ulcer or gastritis in 46 patients (21 HP+), duodenal ulcer or duodenitis in 35 patients (11 HP+), esophageal candidiasis in 28 patients (13 HP+), peptic esophagitis in 3 patients (0 HP+), Kaposi's sarcoma in 6 patients (4 HP+). 11 patients presented with normal findings (1 HP+). CONCLUSION: The prevalence of HP in upper gastrointestinal biopsies is the same in the studied population (33%) as in the general french population (30%). The frequency of HP infection is lower in HIV-infected patients than in HIV negative patients who suffered from gastritis or gastric ulcer (45% vs 70-90%), and duodenitis or duodenal ulcer (31% vs 90%). In our study, no correlation was found between HP+ and sex, HIV risk factor, CD4 count, and antiretroviral therapy.
Publication Types:
Keywords:
- AIDS Vaccines
- Abdominal Pain
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Duodenal Ulcer
- Duodenitis
- Esophagitis
- Female
- Gastritis
- HIV Seropositivity
- Helicobacter Infections
- Helicobacter pylori
- Humans
- Male
- Prevalence
- Prospective Studies
- Stomach Ulcer
- Urease
Other ID:
UI: 102229624
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