Mathurin S, Lupo S, Bortolozzi R, Nannini E, Alonso H; International Conference on AIDS.
Int Conf AIDS. 1998; 12: 328 (abstract no. 22326).
CAICI, Rosario, Argentina.
INTRODUCTION: FUO is a frequent and complex clinical situation in hiv positive patients and require a different approach from non HIV infected patients. OBJECTIVE: To assess the etiology of FUO in HIV positive patients admitted to our hospital, and to evaluate the usefulness of the main diagnostic procedures. DESIGN/METHODS: In a prospective study, we analyzed 38 episodes of FUO in 35 patients (26 male and 9 female) admitted to our hospital between 1994/96. The median age was 31 years (21-46). 26 were intravenous drug abusers, 7 heterosexual and 2 homosexual. FUO was defined as fever higher than 38.3 degrees persisting for more than 4 weeks without etiology after have performed blood and urine cultures and chest and sinus X-rays in HIV positive patients. RESULTS: The etiology of FUO was confirmed in 34 cases (89.5%), five with double etiology. There were 34 infections, 1 NHL, 1 interstitial pneumonitis, 1 Kaposi sarcoma and 1 factitious fever. The major causes of the fever were tuberculosis (17) and disseminated histoplasmosis (9). Those episodes described as double etiology were: PCP/Cryptococosis, Histoplasmosis/Cryptococosis, TBC/KS, TBC/NHL and Histoplasmosis/CMV. In 16 patients the etiology of FUO was an AIDS defining event. The median cd4 count was 170, 16 patients presented cd4 below 100. The most effective invasive diagnostic method was the Lymp node biopsy or aspiration (93%), the liver biopsy (60%) and the skin scarification/biopsy (55%). 14 patients died as the result of the infections that motivated the FUO or as the result an IH complication. CONCLUSIONS: Infections were the most frequent etiology of FUO. TBC and disseminated histoplasmosis should be considered as a first-line diagnosis in our area. Invasive diagnostic methods permit to obtain highs diagnostic efficacy.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Female
- Fever
- Fever of Unknown Origin
- HIV
- HIV Infections
- HIV Seropositivity
- Histoplasmosis
- Homosexuality
- Humans
- Infection
- Male
- Prospective Studies
- Sarcoma, Kaposi
- Tuberculosis
- organization & administration
Other ID:
UI: 102228365
From Meeting Abstracts