Stille W, Brodt HR, Koller-Lampert K, Schulze-Werninghaus G, Jakschik M, Helm EB; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 214 (abstract no. Th.B.O.15).
Universitatsklinik Frankfurt, Zentrum der Inneren Medizin, Frankfurt, FRG
OBJECTIVE: To compare clinical pattern, course and frequency of active TB and MNT in HIV-positive (HIV+) iv drug addicts (IVDA) and pts not HIV-infected or from other risk groups. METHODS: At Frankfurt University Hospital (FUH), all TB/MNT pts have been retrospectively registered since 1973/1980. Since 1982, all HIV+ pts have been examined prospectively. RESULTS: Until 1984, 726 inpatients with TB (ca. 60/year) were treated. Of these, 2 homosexual pts had AIDS, and 2 pts were IVDA (HIV status unknown). None of the 78 pts with proof of MNT had AIDS or was IVDA. From 1982-88, 336 AIDS in- and outpatients (31 IVDA = 9.2%) were treated at FUH. Of 50 HIV+ TB pts, 11 were IVDA. TB was diagnosed before any other AIDS manifestation in 10 out of 11 IVDA, but only in 2 of 39 pts from other risk groups. In IVDA, clinical pattern and course of TB (4x disseminated, 2x lymph nodes, 5x lungs) were more severe than in pts from other risk groups. Of 75 pts with MNT infections, 7 (= 9.3%) were IVDA. Compared to pts from other risk groups, range of pathogens, frequency and clin. course in IVDA did not significantly differ. CONCLUSION: Active TB and other MNT infections are significantly more frequent in HIV+ than in HIV-neg. IVDA. Compared to HIV+ pts from other risk groups, IVDA develop TB earlier, more frequently, and with more severe clinical course. MNT infections in IVDA do not differ from those in pts from other risk groups.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- HIV
- HIV Antibodies
- HIV Infections
- HIV Seropositivity
- HIV Seroprevalence
- Infection
- Mycobacterium Infections
- Substance Abuse, Intravenous
- Substance-Related Disorders
- Tuberculosis
Other ID:
UI: 102176812
From Meeting Abstracts