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Effects of a Large-Scale Intervention with Influenza and 23-Valent Pneumococcal Vaccines in Elderly People: a One-Year Follow-Up.

HEDLUND JU, CHRISTENSON B, LUNDBERGH P, ORTQVIST A; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. G-449.

Dep. of Infectious Diseases, Karolinska Hospital, Stockholm, Sweden

BACKGROUND: To assess the effectiveness of influenza and pneumococcal vaccination in reducing hospitalization and deaths we performed a prospective intervention study of the elderly population in Stockholm County. METHODS: All persons in Stockholm County, aged 65 years and older (259 627 persons) were invited by letter to participate in a vaccination campaign against influenza and pneumococcal infection between September and November 1998. A total of 100,242 persons received influenza (n=23,224) and/or pneumococcal (n=77,018) vaccine. The discharge diagnoses and mortality data for all individuals >/=65 years of age hospitalized in Stockholm County during the year following the vaccination campaign were obtained from the administrative database of Stockholm County Council. RESULTS: During the 12-month observation period, the incidence of hospital treatment was lower in the vaccinated than in the unvaccinated cohort for the investigated diagnoses except for chronic obstructive pulmonary disease (COPD). The total mortality was lower in the vaccinated than in the unvaccinated cohort (OR 0.71, p<0.0001). The results are presented as hospital admissions/100,000 individuals: [table: see text] CONCLUSION: A general vaccination with these vaccines may lead to significant health benefits and to reduction of mortality in elderly individuals.

Publication Types:
  • Meeting Abstracts
Keywords:
  • 23-valent pneumococcal capsular polysaccharide vaccine
  • Aged
  • Hospitalization
  • Humans
  • Incidence
  • Influenza Vaccines
  • Influenza, Human
  • Longitudinal Studies
  • Pneumococcal Infections
  • Pneumococcal Vaccines
  • Prospective Studies
  • Streptococcus pneumoniae
  • Vaccination
  • methods
Other ID:
  • GWAIDS0031031
UI: 102270668

From Meeting Abstracts




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