Chadwick EG, Freeman I, Yogev R, Brown RR; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 288 (abstract no. PO-B02-0918).
Northwestern Univ. Med. Sch., Chicago, IL.
Data suggest that chronic diarrhea and cachexia in adults with AIDS may be related to interferon-induced hypercatabolism of TRP. Deficiency of an essential amino acid such as TRP leads to negative nitrogen balance and poor growth, and may contribute to the FTT commonly seen in pediatric HIV infection. We studied the relationship of TRP metabolism to FTT in HIV-infected (HIV+) children and uninfected controls. Random blood TRP levels were measured using an automated fluorimetric method in 31 HIV+ children (13 with AIDS, 6 of whom had FTT) and 34 controls. TABULAR DATA, SEE ABSTRACT VOLUME. 1p < 0.001 compared w/controls, 2p < 0.001 compared w/non-FTT, 3p < 0.025 compared w/controls CONCLUSION: TRP levels are significantly depressed in HIV+ children, especially those with FTT. Intervention to preserve adequate TRP stores may decrease the incidence of FTT in HIV+ children.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Adult
- Cachexia
- Child
- Child Abuse
- Child Development
- Failure to Thrive
- Growth
- Growth Disorders
- HIV Seropositivity
- Humans
- Incidence
- Interferons
- Malnutrition
- Tryptophan
- Tryptophan Oxygenase
Other ID:
UI: 102203792
From Meeting Abstracts