Bourdoux P, Bonnyns M, Clumeck N; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 267 (abstract no. M.B.P.272).
Saint Pierre University Hospital, B-1000 Brussels, Belgium
Transient TBA are currently observed in nonthyroidal-illness (NTI) and particularly in severe infections but their incidence in AIDS is not yet known. Therefore, we studied the thyroid function in 102 patients with AIDS (stages 1 to 4) aged 19-78 (group 1), in 102 age-sex matched controls with various infectious diseases (group 2) and in 4302 unselected patients aged 15-99 (group 3), admitted to our medical service. Thyroid function was assessed by serum T4, T3, TBG, FTI (T4/TBG) and TSH. When a thyroid disease was suspected, a complete panel of investigations was performed including free T4 and T3, and TRH test. A low T3 syndrome was observed in 20% of all patients, including AIDS patients. Thyroid diseases were found in one patient in group 1 (1%) and in 84 patients in group 3 (2%). In clinically euthyroid patients, the other TBA were distributed as follows (in % in groups 1/ 2/ 3): decreased T4 (7/3/2), decreased FTI (7/1/0.2), increased T4 (1/9/2.7), increased FTI (1/4/1.4), increased TSH (2/2/2). Moreover, in patients of group 3 with high TSH, 1.6% had normal FTI indicating euthyroidism. When compared to controls, patients with AIDS, although euthyroid, had significantly different mean values of T4 (AIDS vs Controls, 7.4 and 8.2 mug/dl, P less than 0.025), T3 (127 and 142 ng/dl, P less than 0.025), FTI (1.26 and 1.55 ng/dl, P less than 0.001), TSH (2.6 and 1.8 muU/ml, P less than 0.01). Mean serum thyroglobulin levels were not different in groups 1 and 2. In conclusion: 1) Decreased T4 frequency is higher in AIDS than in other NTI although the proportion of true thyroid disease is the same; 2) abnormal TBG level accounts for more than half of TBA, particularly in patients with low T4; 3) consequently, FTI is the most appropriate tool for screening thyroid dysfunction in AIDS and NTI patients.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Case-Control Studies
- Down Syndrome
- Euthyroid Sick Syndromes
- Humans
- Hyperthyroidism
- Incidence
- Thyroid Diseases
- Thyroid Function Tests
- Thyroid Gland
- Thyrotropin-Releasing Hormone
- Thyroxine
- Thyroxine-Binding Proteins
- Triiodothyronine
- abnormalities
Other ID:
UI: 102177126
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