DEROUINEAU JG, DHOTTE PC, BUTTET PA; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 348.

Health Dispensary Figuier , Paris, France

BACKGROUND: A PEP for HIV is recommended and freely supplied in France, following HIV transmission risk for a recent unprotected sexual intercourse (< 48 h). The possible antiretroviral (ARV) drug resistance leads using other ARV regimens than AZT+3TC.METHODS: Retrospective study of all PEP delivered in Health Dispensary Figuier for 2 years, between 03/15/98 and 03/15/00.RESULTS: Eighty-three patients (pts) received PEP (72 men, 11 women) with 30 years mean age [19-57]. The 28 day PEP followed unsafe anal/vaginal intercourses (lack/rupture of condom: 36 receptive, 36 insert, 9 oral) and 2 blood exposures. The partners HIV status was positive for 26, unknown for 57. Mean time between HIV risk and PEP start was 26 h [1-59]. PEP was 41 D4T+DDI [29 with protease inhibitor (PI), 12 without], 24 D4T+3TC [7 with PI, 17 without], 5 D4T+DDI+3TC and 13 others. 11 PEP were stopped because of a partners negative HIV. Result: One pt revealed HIV positive during the PEP. 71 PEP were continued. 15 pts were lost of follow-up. Out of the 56 followed, 5 (9%) stopped because of side effects (2 with D4T+DDI). 51 PEP lasted for 28 days, 23 with D4T+DDI [16 with PI, 7 without], 21 with D4T+3TC [6 with PI, 15 without], 7 with others. After PEP end, 23 pts had a HIV serology 5 months later, 13 had one 3 months later, and 7 had one 1 month later only. 4 pts were lost of follow-up after PEP end, and 9 wait for first test control. No HIV seroconversion was observed. Conclusion: D4T+DDI regimen with others ARV or not has been well tolerated in this group of pts and most often allowed the 28 day PEP. No HIV seroconversion has been reported.KEYWORDS: Drugs' tolerability; HIV; Post exposure prophylaxis

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Anti-HIV Agents
• Condoms
• Didanosine
• Female
• France
• HIV
• HIV Infections
• HIV Seropositivity
• Humans
• Lamivudine
• Male
• Paris
• Retrospective Studies
• Stavudine
• Zidovudine
• transmission

Other ID:

• GWAIDS0009828

UI: 102247326

From Meeting Abstracts