Archer H, Miguez-Burbano MJ, Rodriguez A, Burbano X, Pilarte A, Rodriguez N, Shor-Posner G; International Conference on AIDS.

Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. WePeB5973.

University of Miami School of Medicine, Miami, United States

BACKGROUND: Recent reports of a non-significant reduction in the rate of HIV/hospitalizations suggests that HAART may have reached its threshold of effectiveness in reducing clinical morbidity resulting in hospital admissions. METHODS: Rates of hospitalization, discharge diagnosis, medical history, CD4 and viral load were obtained in HIV+ subjects consecutively hospitalized at Jackson Memorial hospital (JMH) and recruited in a cross-sectional study (Sept-Dec 2001). RESULTS: 84 men and 57 women ranging in age from 20-62 (42+/-8) and HIV-infected for a mean of 6 years were hospitalized. Most patients (52%) were African-American, 26% Haitian, 18% Hispanics and 4% white. The mean CD4 was 114+/-145 cells/mm3 and viral load was 353541+/-311378 HIV copies; no significant gender differences were observed. More than half (60%) of the participants were currently on HAART. Hospitalizations were due mainly to infections (75%), renal disorders (8%), malignancy (4%), and others (13%). Only 1% had not been previously hospitalized at JMH, 14% once, 45% 2-4 and 40% had multiple (>5) hospitalizations (MH). After controlling for HAART, no significant associations were observed between MH and current CD4, years with HIV, tobacco use, or drug use history. Women with MH tended to have higher viral loads compared to men with MH (0.07). Univariate analyses indicated that women were 8x more likely to have MH and 3x more likely to have >10 previous hospital admissions. Multivariate analyses, controlling for HAART, revealed that patients with MH were more likely to be female (OR=2.3, p=0.02), black (OR=3, p=0.02) have high current viral loads and an associated renal disease (OR=7.2, p=0.001). CONCLUSIONS: Viral burden, but not CD4, and renal disease appear to be sensitive predictors of MH. The gender differences in higher hospitalization rates require further exploration. Support: Florida Tobacco Research and Fogarty.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antiretroviral Therapy, Highly Active
• Cross-Sectional Studies
• Female
• Florida
• HIV Infections
• HIV Seropositivity
• Haiti
• Hospitalization
• Hospitals
• Humans
• Male
• Prospective Studies
• Sex
• Viral Load

Other ID:

• GWAIDS0014878

UI: 102252376

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