PALACIOS R, SANTOS J, CORRALES M, RUIZ J, GONZALEZ M, MARQUEZ M; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 348.

Hosp. Virgen de la Victoria, Malaga, Spain

BACKGROUND: FSL are rare in HIV patients. We analyze the incidence, etiology, epidemiologic, clinical, immunologic and evolutive characteristics of FSL in aids patients.METHODS: Review of the clinical reports of HIV patients diagnosed between 01/86 and 02/00 who had FSL (ultrasonography or CT) which etiology was confirmed by histology, strains or cultures of specific samples.RESULTS: Two thousand two hundred twenty HIV patients, 889 aids cases; 27 had FSL (3.0%). 23 male; mean age: 34.3 (24-50). HIV risk: IDU (81.4%). Mean CD4: 74.8/ml (1-272; median 54). Sixteen patients had aids previously and the rest ones were aids cases after the etiologic diagnostic of the FSL. Tuberculosis (TB) was the most frequent cause (62.9%, 17/27) and one of the most frequent opportunistic infections in our aids patients (47.2%). 4.0% of the TB cases had FSL (17/420). The other causes: 2 Mycobacterium avium complex, 2 Hodgkins disease, one acute leukemia, one Kaposis sarcoma, one pyogenous abscess due to S. aureus (IDU), one due to Salmonella no-typhi, one by Cryptococcus and a splenic thrombosis. Due to worsening or to get a diagnosis, 9 patients were splenectomized: 4 TB, 3 neoplasms, the splenic thrombosis and the pyogenous abscess. The risk for developing FSL was the greatest in TB cases (RR 2.6; IC 95%: 1.16-5.96; p<0.05). Four TB cases, 3 multidrug-resistant (MDRTB) and the abscess by S. aureus died.CONCLUSIONS: FSL in HIV patients affect immunosuppressed subjects and the etiology is varied, being infectious diseases the most frequent cause. TB supposes more than a third of the cases. In our serie, the probability that a patient with aids and TB would have FSL was more than the double that any other etiology would. The high mortality is partially explained because of the isolation of MDRTB strains.KEYWORDS: AIDS; Focal splenic lesions; Tuberculosis

Publication Types:

• Meeting Abstracts

Keywords:

• Abscess
• Acquired Immunodeficiency Syndrome
• HIV Infections
• HIV Seropositivity
• Humans
• Incidence
• Male
• Sjogren's Syndrome
• Splenic Diseases
• Tuberculosis

Other ID:

• GWAIDS0009833

UI: 102247331

From Meeting Abstracts