GUPTE SV, PATEL MV, JAFRI MA, UPADHYAY DJ, TAKALKAR S, SHETTY N, CHUGH Y, KHORAKIWALA HF, DE SOUZA NJ; Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. F-432.

Wockhardt Research Centre, Aurangabad, India.

BACKGROUND: WCK 1152 & WCK 1153 are enantiomers of a novel FQ WCK 919. METHODS: MICs of WCK 1152, WCK 1153, moxifloxacin (Moxi) and levofloxacin (Levo) were determined against 30 FQS SPN, 10 FQR SPN and 29 (SPV) by NCCLS method. In vivo (p.o.) efficacy of WCK 1152, WCK 1153, Moxi and Levo was evaluated using FQS SPN 731 and 733, FQR SPN 7709 and 5844 and Streptococcus mitis (S. mitis) strains in mouse systemic infection (i.p.) model. Efficacy of WCK 1152, WCK 1153 and Moxi was also determined in immunocompromised mouse lung infection caused by FQR SPN 5844. Infection was given by intratracheal route and treatment by p.o. at doses of 30 and 50 mg/kg for WCK 1152, 20 and 30 mg/kg for WCK 1153 and 75 mg/kg for Moxi. Lung CFU was determined 1 day post treatment. RESULTS: MIC[50] values of WCK 1152, WCK 1153, Moxi and Levo against FQS SPN were 0.03, 0.03, 0.125 and 1.0, against FQR SPN were 0.5, 0.25, 2 and 16 and for SPV were 0.1, 0.05, 0.2 and 1.0 mcg/ml respectively. SPN systemic infections, FQs ED[50] (mg/kg) [table: see text]. FQR SPN lung load reduction by WCK 1152 and WCK 1153 was significantly superior to Moxi. WCK 1152 at 50 and Moxi at 75 mg/kg dose reduced lung bacterial count by 6.32 and 1.46 log respectively. WCK 1153 at a lower dose of 30 mg /kg achieved lung sterility. CONCLUSIONS: WCK 1152 and WCK 1153 show developmental potential as orally effective agents for the management of FQR SPN and viridans infections.

Publication Types:

• Meeting Abstracts

Keywords:

• Animals
• Aza Compounds
• Fluoroquinolones
• Mice
• Microbial Sensitivity Tests
• Ofloxacin
• Quinolines
• Streptococcus pneumoniae
• Viridans Streptococci
• moxifloxacin

Other ID:

• GWAIDS0026062

UI: 102265686

From Meeting Abstracts