Torre D, Zeroli C, Giola M, Ferrario G, Bonetta G, Tambini R; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 196 (abstract no. PO-A19-0371).
Div. of Infectious Diseases, Regional Hospital, Varese, Italy.
Fibronectin receptor (FNR), a member of the integrin beta 1 subfamily and considered as a serum integrin, is involved in specific adhesive interaction between mononuclear cells and extracellular matrix, that is a prerequisite for accumulation of these cells to inflammatory sites and for consequent phagocytosis and killing of microorganisms. We have previously demonstrated a binding of fibronectin to HIV-1 infected cells, and in particular to gp120. This study was designed to determine levels of FNR in patients with HIV-1 infection. An enzymatic immunoassay was used for the quantitative determination of serum FNR (Takara Shuzo, Japan). Our results show a significant increase of FNR levels in the serum of HIV-1 infected patients, especially in those with AIDS (n = 11; P < .0001). In contrast, AIDS patients with neurologic disorders (n = 5) showed normal serum levels of FNR. We suggest that increase of FNR levels in AIDS patients could be related to enhanced expression of FNR in HIV-1 infected cells. In conclusion, the increased levels of FNR in patients with HIV-1 infection may reflect interaction of this circulating receptor with HIV-1 infected cells as well as with circulating gp120.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antigens, CD29
- Extracellular Matrix
- Fibronectins
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- Humans
- Integrin alpha5beta1
- Integrins
- Japan
- immunology
Other ID:
UI: 102203190
From Meeting Abstracts