ZAROTSKY V, JARESKO GS, HOLTOM PD; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. L-776.

University of Southern California Schools of Pharmacy and Medicine, Los Angeles, CA

Background In small studies PTZ has shown comparable to other antipseudomonal beta-lactam regimens. These studies lack the sample size to detect a significant difference. Purpose Utilizing meta-analysis, we evaluated the relative efficacy of PTZ in FNP. Methods A computerized literature search was conducted. Data were abstracted by two investigators. Weighted odds ratios (OR) and 95% confidence intervals (CI) were calculated. OR>1 favors PTZ. Results Seven randomized controlled studies met inclusion criteria. Only one study evaluated PTZ as monotherapy, six evalauated PTZ in combination with aminoglycoside. 1702 cases were identified for analysis. (OR; CI: # of cases) for the following outcomes are: overall clinical cure (1.28; 1.04-1.56:1623) bacteremia (1.15; 0.73-1.80:342), overall mortality (1.11;0.68-1.82:1.13), mortality due of infection (1.54; 0.90-2.64:1620), microbiologic cure (1.79; 0.99-3.25:205), relapse or new bacterial infections (1.42; 1.07-1.89:1313), adverse drug reactions (0.74; 0.54-1.00:1385). Conclusion There was no difference in efficacy between PTZ when compared to the other antibiotic regimens. However PTZ had significantly less superinfecions than its comparators, but significantly greater number of adverse drug reactions. PTZ in combination with an aminoglycoside is effected for treating FNP. More data is needed on PTZ as monotherapy.

Publication Types:

• Meeting Abstracts

Keywords:

• Aminoglycosides
• Anti-Bacterial Agents
• Bacterial Infections
• Humans
• Meta-Analysis
• Odds Ratio
• Penicillanic Acid
• Piperacillin
• beta-Lactams
• tazobactam

Other ID:

• GWAIDS0029869

UI: 102269501

From Meeting Abstracts