University of Wisconsin-Madison, B.S., 1971, Biochemistry
University of Arkansas for Medical Science, Ph.D. 1985 (Biochemistry)

Experience:

• 1999-2000 Acting Director, Division of Chemistry, GS-14, National Center for Toxicological Research; Jefferson, AR
• 1996-Present Special Assistant to the Director, GS-14, National Center for Toxicological Research; Jefferson, AR
• 1992-1995 Assistant Director, Office of Research, GS-13, National Center for Toxicological Research; Jefferson, AR
• 1991-1992 U. S. Food and Drug Administration Mid-Level Management Program Associate.
• 1989-1992 Division of Biochemical Toxicology, GS-13 Research Chemist, National Center for Toxicological Research; Jefferson, AR
• 1988-present Adjunct Assistant Professor, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences; Little Rock, AR,
• 1985-1988 Division of Biochemical Toxicology, GS-12 Research Chemist, National Center for Toxicological Research; Jefferson, AR
• 1978-1984 Division of Biochemical Toxicology, GS-11 Research Chemist, National Center for Toxicological Research; Jefferson, AR
• 1976-1977 Division of Molecular Biology, GS-9 Chemist ,National Center for Toxicological Research; Jefferson, AR
• 1974-1975 McArdle Laboratory for Cancer Research, Project Specialist; Madison, Wisconsin
• 1972-1973 Division of Medicinal Chemistry, OIH20, Biological Laboratory, Assistant, Walter Reed Army Institute of Research; Washington D.C.,.

Honors:

• Department of Health And Human Services Employee of the Month Award, 1996
• U.S. Food and Drug Administration Award of Merit (Group), 1994.
• U.S. Food and Drug Administration Group Recognition Award I, 1992.
• U.S. Food and Drug Administration Group Recognition Award II, 1992.
• U.S. Food and Drug Administration Mid-Level Management Associate, 1991-1992
• U.S. Food and Drug Administration Commendable Service Award, 1991.
• Department of Health and Human Services Long-term Training Award, 1979-1980.

Publications:

• Gross, C., Engbaek, F., Flammang, T. and Burgess, R. (1976) A rapid micromethod for the purification of E. coli RNA polymerase and the preparation of bacterial extracts active in RNA synthesis, J. Bacteriol. 128, 382-389.

• Kadlubar, F., Flammang, T. and Unruh, L. (1978) The role of N-hydroxy arylamine N-glucuronides in arylamine-induced urinary bladder carcinogenesis: Metabolite profiles in acidic) neutral and alkaline urines of 2-naphthylamine- and 2-nitronaphthalene-treated rats, In A. Aitio (ed.), Conjugation Reactions in Drug Biotransformation", Elsevier-North Holland (Shannon, Ireland), pp 443-454.

• Ketterer, B., Kadlubar, F., Flammang, T., Carne, T. and Enderberg, G. (1979) Glutathione adducts in N-methyl-4-aminoazobenzene formed in vivo by reaction of N-benzoyloxy-N-methyl-4-aminoazobenzene with glutathione, Chemical and Biological Interactions 25, 7-21.
  
  
• Kadlubar, F.F., Ketterer, B., Flammang, T.J. and Christodoulides, L. (1980) Formation of 3-(glutathion-S-yl)-N-methyl-4-aminoazobenzene and inhibition of aminoazo dye-nucleic acid binding in vitro by reaction of glutathione with metabolically-generated N-methyl-4-aminoazobenzene-N-sulfate, Chemical and Biological Interactions 31, 265-278.

• Oglesby, L.A., Flammang, T.J., Tullis, D.L. and Kadlubar, F.F. (1981) Rapid absorption, distribution, and excretion of carcinogenic N-hydroxy-arylamines after direct urethral instillation into the rat urinary bladder, Carcinogenesis 2, 15-20.

• Kadlubar, F.F., Unruh, L.E, Flammang, T.J., Sparks, D., Mitchum, R.K. and Mulder, G.J. (1981) Alteration of urinary levels of the carcinogen, N-hydroxy-2-naphthylamine in the rat by control of urinary pH, inhibition of metabolic sulfation and changes in biliary excretion, Chemical and Biological Interactions 33, 129-147.

• Kadlubar, F.F., Melchior, W.B., Flammang, T.J., Gagliano, A.G., Yoshida, H. and Geacintov, N.E. (1981) Structural consequences of the oxygen atom of guanine in DNA by the carcinogen N-hydroxy-1-naphthylamine. Cancer Res. 41, 2168-2174.

• Westra, J.G,, Flammang, T.J., Fullerton, N.F., Beland, F.A., Weis, C.C. and Kadlubar, F.F, (1985) Formation of DNA adducts in vivo in rat liver and intestinal epithelium after administration of the carcinogen, 3,2'-dimethyl-4-aminobiphenyl and its hydroxamic acid, Carcinogenesis 6, 37-44.

• Roberts, D.W., Benson, R.W., Flammang, T.J. and Kadlubar, F.F. (1985) Development of an avidin-biotin amplified enzyme-linked immunoassay for detection of DNA adducts of the human bladder carcinogen 4-aminobiphenyl, In Chappas, Simic, Grossman and Upton (eds), "Mechanisms DNA Damage and Repair", pp. 479-488, Plenum Press, New York, NY.

• Frederick, C.B., Weis, C.C., Flammang, T.J., Martin, C.N. and Kadlubar, F.F. (1985) Hepatic N-oxidation, acetyl-transfer and DNA-binding of the acetylated metabolites of the carcinogen, benzidine, Carcinogenesis 6, 959-965.

• Howard, P.C., Flammang, T.J. and Beland F.A. (1985) In vivo and in vitro hepatic metabolism of the carcinogen 1-nitropyrene, in Cooke, M. and Dennis, A.J. (eds), "Polynuclear Aromatic Hydrocarbons: Mechanisms, Methods and Metabolism" Battelle Laboratories, Columbus, OH, p 771-783.

• Howard, P.C., Flammang, T.J. and Beland, F.A. (1985) Comparison of the in vitro and in vivo hepatic metabolism of the carcinogen 1-nitropyrene, Carcinogenesis 6, 243-249.

• Flammang, T.J., Westra J.G., Kadlubar, F.F. and Beland, F.A. (1985) DNA adducts formed from the probable proximate carcinogen, N-hydroxy-3,2'-dimethyl-4-aminobiphenyl, by acid catalysis or S-acetyl coenzyme A-dependent enzymatic esterification, Carcinogen. 6, 251-258.

• Flammang, Thomas J. and Kadlubar, Fred F. (1985) Acetyl CoA-dependent, cytosol-catalyzed binding of carcinogenic N-hydroxy arylamines to DNA, In A.R. Boobis, J. Caldwell, F. deMateis and C.R. Elcombe (eds), "Microsomes and Drug Oxidations", Taylor and Francis, London and Philadelphia, pp. 170-197.

• Flammang, T.J. and Kadlubar, F.F. (1986) Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissues and species differences other acyl donors and arylhydroxamic acid-dependent acyltransferases, Carcinogenesis, 7, 919-926.

• Lang, N.P., Chu, D.Z.J., Hunter, C.F., Kendall, D.C., Flammang, T.J. and Kadlubar, F.F. (1986) Role of aromatic amine acetyltransferase in human colorectal cancers Archives of Surgery, 121, 1259-1261.

• Hein, D.W., Flammang, T.J., Kirlin, W.G., Trinidad, A. and Ogolla, F. (1987) Acetylator genotype-dependent metabolic activation of carcinogenic N-hydroxyarylamines by S-acetyl coenzyme A-dependent enzymes of inbred hamster tissue cytosols: Relationship to arylamine N-acetyltransferase, Carcinogenesis 8, 1767-1774.

• Flammang, T.J., Yamazoe, Y., Guengerich, F.P. and Kadlubar, F.F. (1987) The S-acetyl coenzyme A-dependent metabolic activation of the carcinogen N-hydroxy-2-aminofluorene by human liver cytosol and its relationship to the aromatic amine N-acetyltransferase phenotype, Carcinogenesis 8, 1967-1970.

• Flammang, T.J., Hein, D.W., Talaska, G. and Kadlubar, F.F. (1988) N-Hydroxy arylamine O-acetyltransferase and its relationship to aromatic amine N-acetyltransferase in inbred hamster and in human tissue cytosol, In C.M. King, L.J. Romano and D. Scheutzle (eds), "Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroarenes", Elsevier, N.Y., pp. 137-148. (Invited Symposium Lecture).

• Roberts, D.W., Benson, R.W., Groopman, J.D., Flammang, T.J., Nagle, W.A., Moss, A.J., and Kadlubar, F.F. (1988) Immunochemical quantitation of DNA adducts from the human bladder carcinogen, 4-aminobiphenyl, Cancer Res. 48, 6336-6342.

• Flammang, T.J., Talaska, G., Chu, D.Z.J., Lang N.L., and Kadlubar, F.F. (1989) N-Acetyltransferase polymorphism and arylamine toxicity: relationship to O-acylation reactions, In D.H. Hutson, J. Caldwell and G.D. Paulson (eds), "Intermediary Xenobiotic Metabolism in Animals", Taylor and Francis, Y., pp. 151- 77. (Invited Symposium Lecture).

• Flammang, T.J., Yamazoe, Y., Benson, R.W., Roberts, D.W., Potter, D.W., Chu, D.Z.J., Lang, N.P., and Kadlubar, F.F. (1989) Arachidonic acid-dependent peroxidative activation of carcinogenic arylamines by extrahepatic human tissue microsomes. Cancer Research 49, 1977-1982.

• Ketterer, B., Meyer, D.J., Lalor, E., Johnson, P., Guengerich, F.P., Distlerath, L.M., Reilly, P.B.B., Kadlubar, F.F., Flammang, T.J., Yamazoe, Y. and Beaune, P.H. (1991) A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human liver. Biochem. Pharmacol. 41, 635-638.

• Flammang, T.J., Yerokun, Y., Bryant, M.S., Couch, L.H., Kirlin, W.G., Lee, K.J., Ogolla, F., Ferguson, R.J., Talaska, G., and Hein, D.W. (1992) Hemoglobin adduct and hepatic- and urinary bladder-DNA adduct levels in rapid and slow acetylator syrian inbred hamsters administered 2-aminofluorene. J. Pharmacol. Exper. Ther. 260, 865-871.

• Flammang, T.J., Couch, L.H., Levy, G.N., Weber, W.W., and Wise, C.K. (1992) DNA adduct levels in congenic rapid- and slow-acetylator mouse strains following chronic administration of 4-aminobiphenyl. Carcinogenesis 13, 1887-1891.

• Flammang, T.J., VonTungeln, L.S., Kadlubar, F.F., and Fu, P.P. (1997) Neonatal Mouse Assay for tumorigencicity. Alternative to the chronic rodent bioassay. Regulatory Toxicology and Pharmacology 26, 230-240.

• Fu, P.P., VonTungeln, L.S., Xia, Q., Ping, Y., Casciano, D.A., Flammang, T.J., and Kadlubar, F.F. (1998) Neonatal Mouse Tumorigenicity Bioassay. Drug Information Journal 32, 711-728.

• Fu, P.P., VonTungeln, L.S., Hammons, G.J., McMahon, G., Wogan, G.N., Flammang, T.J., and Kadlubar, F.F. (1999) Carcinogenicity in the B6C3F1 neonatal mouse: A potential alternative bioassay. Progress in Clinical and Biological Research (In Press).