HIV-1 Reverse Transcriptase Protein Structures Index

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Tutorials and Museum Exhibits

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A tutorial on HIV-1 Reverse Transcriptase structure/function by Matthew Bok Walsh and David Marcey at the Online Macromolecular Museum at California Lutheran University.

HIV Reverse Transcriptase Review in Science:
Huang H, Chopra R, Verdine GL, Harrison SC.
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.
Science. 1998 Nov 27;282(5394):1669-75.
PMID: 9831551 or (PDF file download)

The HIV Drug Resistance Database at LANL and the HIV Drug Resistance Database at Stanford are both sources of information on sites in the protease and reverse transcriptase proteins which mutate to create drug resistance in the virus.

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PDB Structure Entries

Use the buttons below each entry in the list to get the PubMed entry, protein structure database (PDB) entry, open a Protein Explorer session with the entry, or get the NCBI entry (allowing Cn3D viewing) of the entry.

1HHJ: Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3429-33. J Mol Biol. 1985 Nov 5;186(1):205-10. J Mol Biol. 1991 May 20;219(2):277-319. Nature. 1987 Oct 8-14;329(6139):512-8. Cell. 1992 Sep 18;70(6):1035-48. Nature. 1987 Oct 8-14;329(6139):506-12.

Human class I histocompatibility antigen (Hla-A 0201) in complex with a 9 amino acid HIV-1 RT peptide (ILKEPVHGV; residues 309-317 in HXB2 RT).

1RTD: Science 1998 Nov 27;282(5394):1669-75.

HIV-1 (clone HXB2) reverse transcriptase (p65RT/RNAse and p51RT) with DNA/primer duplex and dNTP; 3.2 Angstom resolution.

1HYS: EMBO J 2001 Mar 15;20(6):1449-61.

HIV-1 RT complexed with a polypurine tract RNA:DNA heteroduplex, and monoclonal antibody.

1HVU: EMBO J. 1998 Aug 3;17(15):4535-42. Structure. 1994 Sep 15;2(9):869-76.

HIV-1 RT complexed with a polypurine tract RNA:DNA heteroduplex, and monoclonal antibody.

1BQM: J Mol Biol 1998 Nov 27;284(2):313-23.

HIV-1 RT wild-type complexed with HBY 097 {(S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3- METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2( 1H)-THIONE} RT inhibitor.

1BQN: J Mol Biol 1998 Nov 27;284(2):313-23.

HIV-1 RT Y188L mutant complexed with HBY 097 {(S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3- METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2( 1H)-THIONE} RT inhibitor.

1HQU: J Mol Biol 1998 Nov 27;284(2):313-23. J Mol Biol. 2001 Jun 1;309(2):437-45.

HIV-1 RT K103N mutant complexed with HBY 097 {(S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3- METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2( 1H)-THIONE} RT inhibitor.

1C0T: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with Thiazoloisoindolinone NNRTI BM+21.1326 {(R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3- A]ISOINDOL-5(9BH)-ONE}.

1C0U: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with Thiazoloisoindolinone NNRTI BM+50.0934 {(R)-(+) 5(9BH)-OXO-9B-PHENYL-2,3-DIHYDROTHIAZOLO[2,3- A]ISOINDOL-3-CARBOXYLIC ACID METHYL ESTER}.

1C1B: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with GCA-166 {6-(3",5"-DIMETHYLBENZYL) -1-ETHOXYMETHYL-5-ISOPROPYLURACIL} .

1C1C: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with MKC-442 (Emivirine) analog TNK-6123 {6-CYCLOHEXYLTHIO-1-ETHOXYMETHYL-5-ISOPROPYLURACIL}.

1RT5: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with UC10 {N-[4-CLORO-3-(T-BUTYLOXOME) PHENYL-2-METHYL-3-FURAN-CARBOTHIAMIDE}.

1JLA: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT wild-type complexed with TNK-651 {6-BENZYL-1-BENZYLOXYMETHYL- 5-ISOPROPYL URACIL}.

1JLB: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant complexed with Nevirapine {11-CYCLOPROPYL-5, 11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2",3"-E][1,4]DIAZEPIN-6-ONE}.

1JLC: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant complexed with PETT-2 {N- [[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N"-[5-CHLORO-PYRIDYL]-THIOUREA}.

1JLE: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant.

1JLF: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant complexed with Nevirapine {11-CYCLOPROPYL-5, 11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2",3"-E][1,4]DIAZEPIN-6-ONE}.

1JLG: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant complexed with UC-781 {2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE}.

1JLQ: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT complexed with 739W94 {2-AMINO-6-(3,5-DIMETHYLPHENYL) SULFONYLBENZONITRILE}.

1JKH: J Mol Biol. 2001 Sep 28;312(4):795-805. Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8. Structure. 1995 Sep 15;3(9):915-26. J Mol Biol. 1994 Sep 30;242(4):586-8. J Med Chem. 1996 Apr 12;39(8):1589-600. Nat Struct Biol. 1995 Apr;2(4):293-302. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9518-23. J Med Chem. 1999 Sep 23;42(19):3845-51. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54 ( Pt 5):938-53.

HIV-1 RT Y181C mutant complexed with DMP-266(Efavirenz) {(-)-6- CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1, 4-DIHYDRO-2H-3, 1-BENZOXAZIN-2-ONE}.

1FKP: Biochemistry. 1998 Oct 13;37(41):14394-403. Nat Struct Biol. 1995 Apr;2(4):303-8.

HIV-1 RT K103N mutant complexed with Nevirapine {11-CYCLOPROPYL-5, 11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2",3"-E][1,4]DIAZEPIN-6-ONE}.

1DLO: Structure 1996 Jul 15;4(7):853-60.

HIV-1 RT C280S mutant.

1DTQ: Structure 1996 Jul 15;4(7):853-60.

HIV-1 RT complexed with NNRTI Phenylethylthiazolylthiourea PETT-1 {N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N"-[5-NITRILOMETHYL-PYRIDYL]- THIOUREA} (PETT131A94).

1DTT: Biochemistry. 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with NNRTI Phenylethylthiazolylthiourea PETT-2 {N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N"-[5-CHLORO-PYRIDYL]-THIOUREA}.

1EET: J Med Chem. 2000 Jan 27;43(2):304.

HIV-1 RT complexed with MSC204 {1-(5-BROMO-PYRIDIN-2-YL)-3-[2-(6- FLUORO-2-HYDROXY-3-PROPIONYL-PHENYL)-CYCLOPROPYL]-UREA}.

1EP4: J Med Chem. 2000 Jan 27;43(2):304.

HIV-1 RT complexed with S-1153 {5-(3,5-DICHLOROPHENYL)THIO-4- ISOPROPYL-1-(PYRIDIN-4-YL-METHYL)-1H-IMIDAZOL-2-YL-METHYL CARBAMATE}.

1FK9: Biochemistry. 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with efavirenz {(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL- 4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE.

1FKP: Structure Fold Des 2000 Oct 15;8(10):1089-94.

HIV-1 K103N NNRTI resistance mutant complexed with nevirapine {11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2",3"-E][1,4] DIAZEPIN-6-ONE}.

1FKO: Structure Fold Des 2000 Oct 15;8(10):1089-94.

HIV-1 K103N NNRTI resistance mutant complexed with efavirenz (Dmp-266) {(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3, 1-BENZOXAZIN-2-ONE}

1IKW: Eur J Biochem 2002 Mar;269(6):1670-7.

HIV-1 RT wild type complexed with efavirenz (Dmp-266) {(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3, 1-BENZOXAZIN-2-ONE}

1IKV: Eur J Biochem 2002 Mar;269(6):1670-7.

HIV-1 K103N NNRTI resistance mutant complexed with efavirenz (Dmp-266) {(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3, 1-BENZOXAZIN-2-ONE}

1IKX: Eur J Biochem 2002 Mar;269(6):1670-7.

HIV-1 K103N NNRTI resistance mutant complexed with Pnu142721 {6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4- YLAMINE}.

1IKY: Eur J Biochem 2002 Mar;269(6):1670-7.

HIV-1 wild-type RT complexed with Msc194 {1-[2-(3-ACETYL-2-HYDROXY- 6-METHOXY-PHENYL)-CYCLOPROPYL]-3-(5-CYANO-PYRIDIN-2-YL)-THIOUREA}.

1HNI: Structure 1995 Apr 15;3(4):365-79.

HIV-1 C280S RT complexed with NNRTI alpha-APAR 95845 {(2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE} at 2.8 A resolution.

1HNV: Nat Struct Biol 1995 May;2(5):407-15.

HIV-1 C280S RT complexed with TIBO R 86183 {TETRAHYDRO-IMIDAZO (4,5,1-KJ)(1,4-)BENZODIAZEPIN-2(1H)-ONE AND THIONE DERIVATIVE}.

1HPZ: Nat Struct Biol 1995 May;2(5):407-15.

HIV-1 K103N mutant RT complexed with NNRTI alpha-APA R95845 (Loviride){ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO) ACETAMIDE}.

1HQE: J Mol Biol. 2001 Jun 1;309(2):437-45. Structure. 1996 Jul 15;4(7):853-60.

HIV-1 K103N mutant RT uncomplexed.

1HQU: J Mol Biol. 2001 Jun 1;309(2):437-45. J Mol Biol. 1998 Nov 27;284(2):313-23.

HIV-1 Mutant K103N RT complexed with HBY 097 (a quinoxaline derivative) {(S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3, 4-DIHYDROQUINOXALIN-2(1H)-THIONE}.

1HMV: Proc Natl Acad Sci U S A 1995 Feb 14;92(4):1222-6. J Mol Biol. 1998 Nov 27;284(2):313-23.

Wild-type HIV-1 RT amino-terminal finger and palm domains, one subunit.

1HAR: Structure 1994 Oct 15;2(10):953-61.

Wild-type HIV-1 RT amino-terminal finger and palm domains, one subunit.

1HRH: Science 1991 Apr 5;252(5002):88-95.

Wild-type HIV-1 RT RNAse H domain. (Two RNAse H domains, although RNAse H is only found on p65 of the p51/p65 heterodimer of active RT).

1J5O: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32. J Mol Biol. 1998 Dec 11;284(4):1095-111.

HIV-1 M184I mutant RT complexed with ds-DNA template-primer and monoclonal Ab (1J5O).

1N5Y: EMBO J. 2002 Dec 2;21(23):6614-24.

HIV-1 Reverse Transcriptase Crosslinked To Post-Translocation AZT monophosphate-Terminated DNA (Complex P) and monoclonal Ab (Fab 28).

1N6Q: EMBO J. 2002 Dec 2;21(23):6614-24.

HIV-1 Reverse Transcriptase Crosslinked To Pre-Translocation AZT monophosphate-Terminated DNA (Complex P) and monoclonal Ab (Fab 28).

1QE1: Structure. 1996 Jul 15;4(7):853-60. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10027-32. J Mol Biol. 1998 Dec 11;284(4):1095-111.

HIV-1 M184I mutant RT uncomplexed.

1KLM: Proc Natl Acad Sci U S A 1997 Apr 15;94(8):3984-9.

HIV-1 RT complexed with BHAP U-90152 {(1-(5-METHANSULPHONAMIDO-1H- INDOL-2-YL-CARBONYL) 4-[METHYLAMINO)PYRIDINYL]PIPERAZINE}.

1REV: Structure 1995 Sep 15;3(9):915-26.

HIV-1 RT complexed with 9-CL-TIBO {TETRAHYDRO-IMIDAZO(4,5,1-KJ) (1,4-)BENZODIAZEPIN-2(1H)-ONE}.

1RT1: J Med Chem 1996 Apr 12;39(8):1589-600.

HIV-1 RT complexed with MKC-442 {6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYL URACIL}.

1RT2: J Med Chem 1996 Apr 12;39(8):1589-600.

HIV-1 RT complexed with TNK-651 {6-BENZYL-1-BENZYLOXYMETHYL-5- ISOPROPYL URACIL}.

1RT3: J Med Chem 1996 Apr 12;39(8):1589-600.

HIV-1 RT complexed with 1051U91 {6,11-DIHYDRO-11-ETHYL-6-METHYL-9- NITRO-5H-PYRIDO [2,3-B][1,5]BENZODIAZEPIN-5-ONE}.

1RT4: Biochemistry 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with UC781 {N-[4-CHLORO-3-[(1,1-DIMETHYLETHOXY) IMINO]PHENYL]-2-METHYL-3-FURAN-CARBOTHIAMIDE}.

1RT5: Biochemistry 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with UC10 {N-[4-CLORO-3-(T-BUTYLOXOME)PHENYL-2- METHYL-3-FURAN-CARBOTHIAMIDE}.

1RT6: Biochemistry 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with UC38 {1-METHYL ETHYL 2-CHLORO-5-[[[ (1-METHYLETHOXY)THIOOXO]METHYL]AMINO]-BENZOATE}.

1RT7: Biochemistry 1998 Oct 13;37(41):14394-403.

HIV-1 RT complexed with UC84 {1-METHYL ETHYL 1-CHLORO-5- [[(5,6DIHYDRO-2-METHYL-1,4-OXATHIIN-3-YL)CARBONYL] AMINO]BENZOATE}.

1RTH: Nat Struct Biol 1995 Apr;2(4):293-302.

HIV-1 RT complexed with 1051U91 {6,11-DIHYDRO-11-ETHYL-6-METHYL- 9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE}.

1RTI: Nat Struct Biol 1995 Apr;2(4):293-302.

HIV-1 RT complexed with HEF {1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL THIOTHYMINE}.

1RTJ: Nat Struct Biol 1995 Apr;2(4):303-8.

HIV-1 RT uncomplexed.

1VRT: Nat Struct Biol 1995 Apr;2(4):293-302.

HIV-1 RT complexed with nevirapine {DIPYRIDODIAZEPINONE NEVIRAPINE}.

1VRU: Nat Struct Biol 1995 Apr;2(4):293-302.

HIV-1 RT complexed with AAP {ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2- ACETYL-5-METHYLANILINO)ACETAMIDE}.

1TVR: J Mol Biol 1996 Dec 20;264(5):1085-100.

HIV-1 RT complexed with 9-chloro-TIBO {9-CL-TETRAHYDRO-IMIDAZO (4,5,1-KJ)(1,4-)BENZODIAZEPIN-2(1H)-ONE AND THIONE DERIVATIVE}.

1UWB: J Mol Biol 1996 Dec 20;264(5):1085-100.

HIV-1 RT Y181C mutant complexed with 8-chloro-TIBO {8-CL-TETRAHYDRO-IMIDAZO (4,5,1-KJ)(1,4-)BENZODIAZEPIN-2(1H)-ONE AND THIONE DERIVATIVE}.

2HMI: J Mol Biol. 1998 Dec 11;284(4):1095-111.

HIV-1 RT complexed with dsDNA and monoclonal antibody Fab28.

3HVT: J Mol Biol. 1998 Dec 11;284(4):1095-111.

HIV-1 RT complexed with nevirapine.

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Other Tables of HIV-1 Reverse Transcriptase Structures

The Reverse Transcriptase Structures Table at the Protein Structures Database (PDB) contains RT structures and RT-related stuctures (such as E. coli Klenow fragment), collected as a part of the September 2002 "Molecule of the Month" project at PDB.

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