National Institute of Arthritis and Muscloskeletal and Skin Diseases (NIAMS)
2004 FASEB Summer Research Conferences:
Biology of Calpains in Health and Disease
June 12 – 17, 2004 • Tucson, AZ
Agenda
| Saturday, June 12 |
|
| 4:00 p.m. | Conference Registration |
| 6:00 p.m. | FASEB Opening Reception |
| 7:00 p.m. | Dinner |
| 8:30 p.m. | After-dinner talk |
| Sunday, June 13 |
|
| Session 1: The calpain gene family: Introduction Session Chair: Dr. Ron Mellgren, Medical College of Ohio and Dr. Neil Forsberg, Oregon State University |
|
| 1:00 p.m. | The world of cysteine peptidases, and the place of calpains in it Dr. Alan Barrett, Sanger Institute: Keynote Speaker |
| 1:45p.m. | The calpain system: Remaining questions Dr. Darrel Goll, University of Arizona |
| 3:00 p.m. | Phytocalpains: Plant orthologous calcium-dependent cysteine proteases Dr. Rogerio Margis, Federal University of Rio de Janeiro, Brazil |
| 3:45p.m. | Unexpectedly different invasive phenotypes of calpain1- and 2-antisense cell lines: Non-overlapping roles of ubiquitous calpains in vivo? Dr. Shirley Gil-Parado, LMU University, Germany |
| Session 2: Calpain structure: Biophysical aspects of calpain activation Session Chairs: Dr. D. Goll (U. Arizona) and Dr. P. Davies (Queen’s University) |
|
| 7:00 p.m. | Calpain activation and inhibition Dr. Tudor Moldoveanu, McGill University |
| 7:45 p.m. | Structure of mu-like calpain Dr. Zongchao Jia, Queen’s University |
| 9:00 p.m. | The protease core of muscle-specific calpain, p94 Dr. Peter Davies, Queen’s University |
| 9:40 p.m. | Axonal damage and neuron death in MS and EAE: A pivotal role for calpain in demyelination Dr. Narin Banik, South Carolina. |
| Monday, June 14 |
|
| Session 3: Physiological roles of calpains Session Chairs: Dr. Hiroyuki Sorimachi (U. Tokyo) and Dr. Koichi Suzuki (Toray, Japan) |
|
| 1:00 p.m. | Physiological functions of stomach-specific calpain, nCL-2/calpain-8, revealed by genetically-modified mice Dr. Shoji Hata, University of Tokyo |
| 1:30 p.m. | Physiological function of mu-calpain in platelet signalling Dr. Athar Chishti, University of Illinois |
| 2:45 p.m. | Knock-in mice reveal novel functions of muscle-specific calpain p94/calpain-3 in non-muscle cells. Dr. Hiroyuki Sorimachi, University of Tokyo |
| 3:30 p.m. | Regulation of ubiquitous calpains by growth factors and chemokines during cell motility Dr. Alan Wells, University of Pittsburgh |
| 4:15 p.m. | Calpain facilitates GLUT-4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes Dr. Yashomati Patel, University of North Carolina |
| Session 4: Calpains and striated muscle disease Session Chairs: Dr. M. Spencer (UCLA) and Dr. Isabelle Richard |
|
| 7:00 p.m. | Calpains in muscle protein turnover Dr. Neil Forsberg, Oregon State University |
| 7:40 p.m. | Development of an assay system for p94/calpain-3 toward diagnosis of muscular dystrophy Dr. Yasuko Ono, University of Tokyo |
| 8:20 p.m. | Linking calpain-3 to the sarcomere Dr. Melissa Spencer, UCLA |
| 9:10 p.m. | Testing the role of calpain-3 in mdm mouse muscular dystrophy Dr. Gregory Cox, Jackson Laboratory |
| 9:50 p.m. | Calpain-3 and limb girdle muscular dystrophy 2A Dr. Isabelle Richard, Genethon, France |
| Tuesday, June 15 |
|
| Session 5: The calpains in pathology- I Session Chairs: Dr. P. Tompa (Hungarian Academy of Science) and Dr. Y. Patel (UNC) |
|
| 1:00 p.m. | How broad is clinical variability in calpainopathy? Dr. Mayana Zatz, University of Sao Paulo, Brazil |
| 1:45 p.m. | Calpains and cataract Dr. Thomas Shearer, Oregon Health Sciences University |
| Calpains in muscle damage in exercise Dr. Jeff Widrick, Oregon State University |
|
| Calpain mechanisms in motility and chemotaxis Dr. Mary Lokuta, University of Wisconsin |
|
| Session 6: The calpains in pathology II Session Chairs: Dr. S. Gil-Parado (LMU, Germany) and Dr. N. Tavernarakis (Greece) |
|
| Role of calpain in myocardial ischemia/reperfusion injury Dr. Roberta Gottlieb, Scripps Institute |
|
| Calcium and protease cascades in neurodegeneration Dr. Nektarios Tavernarakis, IMBB, Greece |
|
| Involvement of calpain in retinopathy Dr. Mitsuyoshi Azuma, Senju Pharmaceuticals, Japan |
|
| 9:45 p.m. | The calpain “degradome” Dr. Kevin Wang, University of Florida |
| Wednesday, June 16 |
|
| Session 7: Calpain inhibitors in the treatment of disease Dr. K. Wang (U. Florida) and Dr. P. Friedrich (Hungarian Academy of Science) |
|
| 1:00 p.m. | A novel small subunit for mammalian calpains Dr. Peter Friedrich, Hungarian Academy of Science |
| 1:45 p.m. | Calpain inhibitors: A treatment of Alzheimer’s disease Dr. Ottavio Arancio, NYU School of Medicine |
| 3:00 p.m. | Activation of calpains by fragments of its unstructured inhibitor, calpastatin Dr. Peter Tompa, Hungarian Academy of Sciences |
| 3:45 p.m. | Calpain inhibitors as therapeutic agents in neuromuscular and neutrodegenerative diseases Dr. Alfred Stracher, (New York) |
| Session 8: Agricultural applications of calpains Session Chairs: Dr. Tom Shearer (Oregon Health Sciences University) and Dr. M. Koohmaraie (USDA-MARC) |
|
| 7:00 p.m. | The role of calpain-3 and calpain-10 in meat tenderization Dr. Roy Bickerstaffe, Lincoln University, NZ |
| 7:40 p.m. | The role of calpains in postmortem proteolysis and tenderness Dr. Mohammad Koohmaraie, USDA-MARC, Nebraska |
| 9:00 p.m. | Involvement of the proteasome and lysosome in calpain-3-deficient mice Dr. Didier Attaix, INRA, France |
| 9:45 p.m. | Influence of nutrition on calpastatin in skeletal muscle Dr. Steven Lonergan, Iowa State University |
| Thursday, June 17 |
|
| 9:00a.m. | Session 9: Calpains: Student Perspectives Session Chairs: Dr. R. Bickerstaffe (Lincoln U, NZ) and Dr. Y. Ono (U.Tokyo) |
| Murachi Awards | |
| 1:30 p.m. | End of Conference |
Participants
| James P. Alexander Triple Point Biologics 2230 Pacific Avenue Forest Grove, OR 97116 John Anagli Ottavio Arancio David D. Arrington Didier Attaix Mitsuyoshi Azuma Naren L. Banik Ronald G. Bardsley Alan J. Barrett Marc Bartoli Norman W. Barton Roy Bickerstaffe Athar H. Chishti Gregory A. Cox Dorothy E. Croall Dominic Cuerrier Eric P. Czerwinski Peter L. Davies Roberta De Tullio Beatriz G. Diaz Tim Edmunds Neil Forsberg Peter Friedrich Matthew Garcia James W. Geddes Darrel E. Goll Roberta A. Gottlieb Shoji Hata Elisabeth J. Huff-Lonergan Jun Inoue Zongchao Jia Sarah B. Kennett Mohammad Koohmaraie Nechama S. Kosower Suguru Koyama Irina Kramerova Elena Kudryashova Rene Lametsch Mary A. Lokuta Steven M. Lonergan Carol L. Lorenzen Kasey R. Maddock Ronald L. Mellgren Edon Melloni Tudor Moldoveanu Jim D. Morton Emi Nakajima Christiane Neuhof Heinz Neuhof Yasuko Ono Tim Parr Yashomati M. Patel Bernadette Pignol Oliver H. Popp David A. Potter Isabelle Richard John D. Roberts Masataka Saito Rick G. Schnellmann Thomas R. Shearer Aleem Siddigui Hiroyuki Sorimachi Melissa Spencer Anjajah Srirangam Alfred Stracher Yunchao Su Koichi Suzuki Jiro Takano Agnes Tantos Nektarios N. Tavernarakis Margrethe Therkildsen Valery F. Thompson Peter Tompa Barbara A. Tremper-Wells Kevin Wang Alan Wells Jeffrey J. Widrick Yi-Lin Yang Mayana Zatz Francis H. Zbikowski |
Summary
The third FASEB-sponsored meeting, which focused on the biology of calpains, was held in Tucson, AZ, on June 12–17, 2004. The meeting consisted of 35 invited speakers and attracted a total of 85 attendees (including 33 invited speakers). The program was divided into sessions that included:
Invited speakers and attendees came from the United States, Canada, the United Kingdom, France, New Zealand, Israel, Denmark, Greece, Germany, Italy, Brazil, Hungary, Korea, and Cuba. Following the main sessions, 6 students were invited to present short talks to compete for the Murachi Awards and 4 speakers were chosen to give “Late-breaking research presentations." Each afternoon session had a discussion session chaired by 2 scientists. Overall, from the Chairperson’s perspectives, the meeting was very successful. It created a good feeling of inclusiveness and helped establish “calpain” as a viable area of study. It successfully attracted a broad range of scientists and many attendees commented that this was an excellent meeting. It was decided that another meeting would be held in 2006 and that Drs. Melissa Spencer (UCLA) and David Potter (Indiana University) would serve as Co-chairs. |
 |
|
 |