Ramos G, Cuenca-Estrella M, Monzon A, Martinez-Suarez JV, Rodriguez-Tudela JL; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1998 Sep 24-27; 38: 453 (abstract no. J-10).

Instituto de Salud Carlos III, Madrid, Spain.

UR-9825 is a new triazole derivative with potent broad spectrum antifungal activity. The antifungal in vitro activity of UR-9825 was assessed in comparison with that of ITR and FLZ against 254 yeast clinical isolates. The MICs were determined using the NCCLS microdilution reference method with minor modifications (RPMI-2% glucose). Isolates were recovered for the last six months from 47 different Spanish hospitals. Each strain represented a unique isolate from a patient The majority of isolates (n=148) were from blood culture specimens. The MICs90/MODE (microgram/ml) are shown below (Table: see text) UR-9825 presents higher in vitro activity than FLZ and ITR against Candida spp. isolates. This new triazole was active against all 11 strains of C. krusei and 33 of C. glabrata (MIC90 0,03 and 0,0015 microgram/ml respectivily), species with high MICs to FLZ and ITR. Clinical and bioavailability studies are needed to determine whether this in vitro results accurately predict clinical utility.

Publication Types:

• Meeting Abstracts

Keywords:

• Antifungal Agents
• Candida
• Candidiasis
• Fluconazole
• Humans
• In Vitro
• Itraconazole
• Miconazole
• Microbial Sensitivity Tests
• Quinazolines
• Saccharomyces cerevisiae
• Triazoles
• albaconazole

Other ID:

• 20711091

UI: 102188443

From Meeting Abstracts