Cardiac Development and Function
Mouse Models Maturation and aging in FVB Cardiac characterization of inbred strains Rat Models Cardiac function of inbred and consomic rats under 12% or 21% O2 Expression Profiles Maturation and aging in FVB Comparative Sequence Analysis NKX2.5 MEF2C GATA4 GATA5 GATA6 SRF
Mouse Models Maturation and aging in FVB Cardiac characterization of inbred strains
Rat Models Cardiac function of inbred and consomic rats under 12% or 21% O2
Expression Profiles Maturation and aging in FVB
Comparative Sequence Analysis NKX2.5 MEF2C GATA4 GATA5 GATA6 SRF
Cardiomyopathy
Mouse Models C57BL/6J Dilated Cardiomyopathy HLB#133 C57BL/6J Tachycardia HLB#345 C57BL/6J Bradycardia with prolonged QT and PR intervals HLB#376 SNPs MYH7: Beta-cardiac myosin heavy chain MYBPC3: Cardiac myosin binding protein C MYL2: Myosin regulatory light chain MYL3: Myosin essential light chain 3 TPM1: Alpha-tropomyosin TNNT2: Cardiac troponin T Sarcomere Mutations MYH7: Cardiac beta-Myosin Heavy Chain MYBPC3: Cardiac beta-Myosin Heavy Chain TNNT2: Cardiac Troponin T TNNI3: Cardiac Troponin I Clinical Features Patients with sarcomere gene mutations Probands being analyzed Antibody Production MLCK2: Myosin light chain kinase 2 Myoglobin PLN: phospholamban TPM2: Tropomyosin 2 TNNI3: Cardiac Troponin I
Mouse Models C57BL/6J Dilated Cardiomyopathy HLB#133 C57BL/6J Tachycardia HLB#345 C57BL/6J Bradycardia with prolonged QT and PR intervals HLB#376
SNPs MYH7: Beta-cardiac myosin heavy chain MYBPC3: Cardiac myosin binding protein C MYL2: Myosin regulatory light chain MYL3: Myosin essential light chain 3 TPM1: Alpha-tropomyosin TNNT2: Cardiac troponin T
Sarcomere Mutations MYH7: Cardiac beta-Myosin Heavy Chain MYBPC3: Cardiac beta-Myosin Heavy Chain TNNT2: Cardiac Troponin T TNNI3: Cardiac Troponin I
Clinical Features Patients with sarcomere gene mutations Probands being analyzed
Antibody Production MLCK2: Myosin light chain kinase 2 Myoglobin PLN: phospholamban TPM2: Tropomyosin 2 TNNI3: Cardiac Troponin I
Cardiac Hypertrophy
Mouse Models Pressure-overload induced hypertrophy (FVB) Exercise induced hypertrophy (FVB) Expression Profiles Pressure-overload induced hypertrophy (FVB) Exercise induced hypertrophy (FVB) Isoproterenol induced hypertrophy
Mouse Models Pressure-overload induced hypertrophy (FVB) Exercise induced hypertrophy (FVB)
Expression Profiles Pressure-overload induced hypertrophy (FVB) Exercise induced hypertrophy (FVB) Isoproterenol induced hypertrophy
Myocardial Infarction
Mouse Models Histology Literature
Essential Hypertension
Mouse Models C57BL/6J Hypertension HLB#10 (heritable, available) C57BL/6J Hypertension HLB#12 (heritable, available) C57BL/6J Hypertension HLB#13 (heritable, available) C57BL/6J Hypertension HLB#15 (heritable, available) C57BL/6J Hypertension HLB#27 (heritable, available) C57BL/6J Hypertension HLB#39 (heritable, available) C57BL/6J Hypertension HLB#40 (heritable, available) C57BL/6J Hypertension HLB#54 (heritable, available) C57BL/6J Hypertension HLB#59 (heritable, available) C57BL/6J Hypertension HLB#60 (heritable, available) C57BL/6J Hypertension HLB#66 (heritable, available) C57BL/6J Hypertension HLB#68 (heritable, available) C57BL/6J Hypertension HLB#72 (heritable, available) C57BL/6J Hypertension HLB#73 (heritable, available) C57BL/6J Hypertension HLB#75 (heritable, available) C57BL/6J Hypertension HLB#76 (heritable, available) C57BL/6J Hypotension HLB#308 Rat Models Renal physiology under high and low salt of inbred and consomic rats Vascular responses under chemical stressors of inbred and consomic rats QTL maps A mouse QTL map QTL for blood pressure in CBA/CaJ and BALB/cJ inbred mice Concordance of mouse QTL for salt-induced hypertension with rat and human loci Expression Analysis Background of using B6 and A/J inbred mice as a model View/download data from the expression analysis of B6 and A/J inbred mice Background of using a mutant C57BL6 mouse: JAX HLB#27 View/download data from the expression analysis of JAX HLB#27 Biochemical pathway Renin-Angiotensin pathway SNPs ACE: Angiotensin I Converting Enzyme (CardioGenomics) ACE: Angiotensin I Converting Enzyme (Southwestern) ACE2: Angiotensin I Converting Enzyme 2 AGT: Angiotensinogen REN: Renin AGTR1: Angiotensin receptor 1 AGTR2: Angiotensin receptor 2 Comparative Sequence Analysis ACE: Angiotensin I Converting Enzyme ACE2: Angiotensin I Converting Enzyme 2 AGT: Angiotensinogen REN: Renin AGTR1: Angiotensin receptor 1 AGTR2: Angiotensin receptor 2 SLC4A1: Chloride-bicarbonate exchanger gene AE1 Antibody Production EDN1: Endothelin 1
Mouse Models C57BL/6J Hypertension HLB#10 (heritable, available) C57BL/6J Hypertension HLB#12 (heritable, available) C57BL/6J Hypertension HLB#13 (heritable, available) C57BL/6J Hypertension HLB#15 (heritable, available) C57BL/6J Hypertension HLB#27 (heritable, available) C57BL/6J Hypertension HLB#39 (heritable, available) C57BL/6J Hypertension HLB#40 (heritable, available) C57BL/6J Hypertension HLB#54 (heritable, available) C57BL/6J Hypertension HLB#59 (heritable, available) C57BL/6J Hypertension HLB#60 (heritable, available) C57BL/6J Hypertension HLB#66 (heritable, available) C57BL/6J Hypertension HLB#68 (heritable, available) C57BL/6J Hypertension HLB#72 (heritable, available) C57BL/6J Hypertension HLB#73 (heritable, available) C57BL/6J Hypertension HLB#75 (heritable, available) C57BL/6J Hypertension HLB#76 (heritable, available) C57BL/6J Hypotension HLB#308
Rat Models Renal physiology under high and low salt of inbred and consomic rats Vascular responses under chemical stressors of inbred and consomic rats
QTL maps A mouse QTL map QTL for blood pressure in CBA/CaJ and BALB/cJ inbred mice Concordance of mouse QTL for salt-induced hypertension with rat and human loci
Expression Analysis Background of using B6 and A/J inbred mice as a model View/download data from the expression analysis of B6 and A/J inbred mice Background of using a mutant C57BL6 mouse: JAX HLB#27 View/download data from the expression analysis of JAX HLB#27
Biochemical pathway Renin-Angiotensin pathway
SNPs ACE: Angiotensin I Converting Enzyme (CardioGenomics) ACE: Angiotensin I Converting Enzyme (Southwestern) ACE2: Angiotensin I Converting Enzyme 2 AGT: Angiotensinogen REN: Renin AGTR1: Angiotensin receptor 1 AGTR2: Angiotensin receptor 2
Comparative Sequence Analysis ACE: Angiotensin I Converting Enzyme ACE2: Angiotensin I Converting Enzyme 2 AGT: Angiotensinogen REN: Renin AGTR1: Angiotensin receptor 1 AGTR2: Angiotensin receptor 2 SLC4A1: Chloride-bicarbonate exchanger gene AE1
Antibody Production EDN1: Endothelin 1
Lipid Metabolism
Random Mouse Mutagenesis Models C57BL/6J Hypercholesterolemia HLB#245 C57BL/6J Hypercholesterolemia with low HDL HLB#154 C57BL/6J Hypercholesterolemia with low HDL HLB#241 C57BL/6J Hypercholesterolemia with low HDL low glucose HLB#105 C57BL/6J Hypercholesterolemia with low HDL low glucose HLB#347 C57BL/6J Hypocholesterolemia with low HDL HLB#192 C57BL/6J Hypocholesterolemia with low HDL HLB#218 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#237 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#252 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#320 C57BL/6J Change in cholesterol on atherogenic diet HLB#300 (heritable) C57BL/6J High triglyceride HLB#213 C57BL/6J High triglyceride HLB#275 C57BL/6J High triglyceride HLB#322 C57BL/6J Hypercholesterolemia with high triglyceride HLB#274 C57BL/6J Hypercholesterolemia with high triglyceride HLB#293 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#253 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#254 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#255 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#291 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#294 C57BL/6J Hypercholesterolemia with high HDL HLB#239 (heritable) C57BL/6J Hypercholesterolemia with high HDL HLB#242 C57BL/6J Hypercholesterolemia with high HDL HLB#280 C57BL/6J Hypercholesterolemia with high HDL HLB#292 C57BL/6J Hypercholesterolemia with high HDL HLB#296 C57BL/6J Hypercholesterolemia with high HDL HLB#338 C57BL/6J High HDL HLB#204 C57BL/6J High HDL HLB#211 (heritable) C57BL/6J High HDL HLB#212 (heritable) C57BL/6J High HDL HLB#250 (heritable) C57BL/6J High HDL HLB#287 C57BL/6J Low HDL HLB#206 (heritable) C57BL/6J Low HDL HLB#207 C57BL/6J Low HDL HLB#209 C57BL/6J Low HDL HLB#216 (heritable) C57BL/6J Low HDL HLB#238 C57BL/6J Low HDL HLB#244 C57BL/6J Low HDL HLB#246 C57BL/6J Low HDL HLB#277 C57BL/6J Low HDL HLB#283 C57BL/6J Low HDL HLB#286 C57BL/6J Low HDL HLB#295 (heritable) C57BL/6J Low HDL HLB#309 C57BL/6J Low HDL HLB#339 C57BL/6J Low HDL HLB#340 Animal Models of Target Genes Abca1 trangenics and knockouts Abcg5/Abcg8 trangenics with specific CNS deletions Apoa5 trangenics and knockouts Srebf1 knockout Srebf2 knockout Inbred and Consomic Animal Models Plasma and hepatic cholesterol of inbred mice Serum chemistry of inbred mice Plasma chemistry of inbred and consomic rats in 12% or 21% O2 SNPs ABCA1 ACAA2 ACAT1 ACAT2 APOA1/C3/A4/A5 gene cluster APOA1 APOC3 APOA4 APOA5 APOE/C1/C4/C2 gene cluster APOE APOC1 APOC4 APOC2 APOBEC2 APOD CD36L1 CYP7A1 CYP7B1 LCAT LIPA LIPE LXRa LXRb PLTP PPARG RXRA RXRB SREBF1 SREBF2 QTL maps Mouse HDL cholesterol Four QTL for HDL cholesterol found in CAST/Ei and DBA/2J inbred mice QTL for HDL cholesterol found in SM/J and NZB/B1NJ inbred mice Comparative Sequence Analysis ABCA1 ABCG5/G8 APOA1/C3/A4/A5 gene cluster APOA2 APOE/C1/C4/C2 gene cluster CYP7A1 LCAT LDLR LIPG LPL LXRa PLTP SLC22A4/A5 TNFa/TNFb Antibody Production APOA1 APOA5 APOC4 APOD FABP1: Fatty acid binding protein 1 LIPE: Hormone sensitive lipase RXRb
Random Mouse Mutagenesis Models C57BL/6J Hypercholesterolemia HLB#245 C57BL/6J Hypercholesterolemia with low HDL HLB#154 C57BL/6J Hypercholesterolemia with low HDL HLB#241 C57BL/6J Hypercholesterolemia with low HDL low glucose HLB#105 C57BL/6J Hypercholesterolemia with low HDL low glucose HLB#347 C57BL/6J Hypocholesterolemia with low HDL HLB#192 C57BL/6J Hypocholesterolemia with low HDL HLB#218 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#237 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#252 (heritable) C57BL/6J Hypocholesterolemia with low HDL HLB#320 C57BL/6J Change in cholesterol on atherogenic diet HLB#300 (heritable) C57BL/6J High triglyceride HLB#213 C57BL/6J High triglyceride HLB#275 C57BL/6J High triglyceride HLB#322 C57BL/6J Hypercholesterolemia with high triglyceride HLB#274 C57BL/6J Hypercholesterolemia with high triglyceride HLB#293 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#253 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#254 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#255 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#291 C57BL/6J Hypercholesterolemia with high triglyceride, high HDL HLB#294 C57BL/6J Hypercholesterolemia with high HDL HLB#239 (heritable) C57BL/6J Hypercholesterolemia with high HDL HLB#242 C57BL/6J Hypercholesterolemia with high HDL HLB#280 C57BL/6J Hypercholesterolemia with high HDL HLB#292 C57BL/6J Hypercholesterolemia with high HDL HLB#296 C57BL/6J Hypercholesterolemia with high HDL HLB#338 C57BL/6J High HDL HLB#204 C57BL/6J High HDL HLB#211 (heritable) C57BL/6J High HDL HLB#212 (heritable) C57BL/6J High HDL HLB#250 (heritable) C57BL/6J High HDL HLB#287 C57BL/6J Low HDL HLB#206 (heritable) C57BL/6J Low HDL HLB#207 C57BL/6J Low HDL HLB#209 C57BL/6J Low HDL HLB#216 (heritable) C57BL/6J Low HDL HLB#238 C57BL/6J Low HDL HLB#244 C57BL/6J Low HDL HLB#246 C57BL/6J Low HDL HLB#277 C57BL/6J Low HDL HLB#283 C57BL/6J Low HDL HLB#286 C57BL/6J Low HDL HLB#295 (heritable) C57BL/6J Low HDL HLB#309 C57BL/6J Low HDL HLB#339 C57BL/6J Low HDL HLB#340
Animal Models of Target Genes Abca1 trangenics and knockouts Abcg5/Abcg8 trangenics with specific CNS deletions Apoa5 trangenics and knockouts Srebf1 knockout Srebf2 knockout
Inbred and Consomic Animal Models Plasma and hepatic cholesterol of inbred mice Serum chemistry of inbred mice Plasma chemistry of inbred and consomic rats in 12% or 21% O2
SNPs ABCA1 ACAA2 ACAT1 ACAT2 APOA1/C3/A4/A5 gene cluster APOA1 APOC3 APOA4 APOA5 APOE/C1/C4/C2 gene cluster APOE APOC1 APOC4 APOC2 APOBEC2 APOD CD36L1 CYP7A1 CYP7B1 LCAT LIPA LIPE LXRa LXRb PLTP PPARG RXRA RXRB SREBF1 SREBF2
QTL maps Mouse HDL cholesterol Four QTL for HDL cholesterol found in CAST/Ei and DBA/2J inbred mice QTL for HDL cholesterol found in SM/J and NZB/B1NJ inbred mice
Comparative Sequence Analysis ABCA1 ABCG5/G8 APOA1/C3/A4/A5 gene cluster APOA2 APOE/C1/C4/C2 gene cluster CYP7A1 LCAT LDLR LIPG LPL LXRa PLTP SLC22A4/A5 TNFa/TNFb
Antibody Production APOA1 APOA5 APOC4 APOD FABP1: Fatty acid binding protein 1 LIPE: Hormone sensitive lipase RXRb
Thrombosis
Mouse Models Coagulation capability of inbred strains C57BL/6J Hyperfibrinogenemia HLB#28 SNPs FGA: Fibrinogen, A alpha peptide FGB: Fibrinogen, B beta peptide FGG: Fibrinogen, gamma peptide F2R: Coagulation factor II receptor F2RL1: Coagulation factor II - receptor like 1 F2RL2: Coagulation factor II - receptor like 2 F2RL3: Coagulation factor II - receptor like 3 F13A1: Coagulation factor XIII GP1BA: Glycoprotein Ib (platelet), alpha polypeptide PLAU: Plasminogen activator PROC: Protein C PROCR: Protein C receptor PROZ: Protein Z SERPINA5: Serine proteinase inhibitor A5 SERPINC1: Serine proteinase inhibitor C1 SERPINE1: Serine proteinase inhibitor E1 Comparative Sequence Analysis ITGA2 ITGA2B Coagulation factor receptors F2RL1/F2R/F2RL2
Mouse Models Coagulation capability of inbred strains C57BL/6J Hyperfibrinogenemia HLB#28
SNPs FGA: Fibrinogen, A alpha peptide FGB: Fibrinogen, B beta peptide FGG: Fibrinogen, gamma peptide F2R: Coagulation factor II receptor F2RL1: Coagulation factor II - receptor like 1 F2RL2: Coagulation factor II - receptor like 2 F2RL3: Coagulation factor II - receptor like 3 F13A1: Coagulation factor XIII GP1BA: Glycoprotein Ib (platelet), alpha polypeptide PLAU: Plasminogen activator PROC: Protein C PROCR: Protein C receptor PROZ: Protein Z SERPINA5: Serine proteinase inhibitor A5 SERPINC1: Serine proteinase inhibitor C1 SERPINE1: Serine proteinase inhibitor E1
Comparative Sequence Analysis ITGA2 ITGA2B Coagulation factor receptors F2RL1/F2R/F2RL2
Asthma and Airway Inflammatory Response
Mouse Models C57BL/6J Airway Hyper-response HLB#102 (heritable mutant) C57BL/6J Airway Hyper-response HLB#168 C57BL/6J Airway Hyper-response HLB#170 C57BL/6J Airway Hyper-response HLB#171 (heritable mutant) C57BL/6J Airway Hyper-response HLB#173 (heritable mutant) C57BL/6J Airway Hyper-response HLB#177 C57BL/6J Airway Hyper-response HLB#178 C57BL/6J Airway Hyper-response HLB#259 C57BL/6J Airway Hyper-response HLB#260 C57BL/6J Airway Hyper-response HLB#261 C57BL/6J Airway Hyper-response HLB#262 C57BL/6J Airway Hyper-response HLB#263 C57BL/6J Airway Hyper-response HLB#264 C57BL/6J Airway Hyper-response HLB#267 C57BL/6J Airway Hyper-response HLB#268 C57BL/6J Airway Hyper-response HLB#269 C57BL/6J Airway Hyper-response HLB#270 C57BL/6J Airway Hyper-response HLB#271 C57BL/6J Airway Hyper-response HLB#362 SNPs IL10 (Innate Immunity) IL10 (SeattleSNPs) Toll-like receptor 4 Toll-like receptor 2 Toll-like receptor 9 Expression Profiles Protocol of mice exposing to endotoxin (LPS) aerosol Hybridization design of mice exposing to endotoxin (LPS) aerosol Download/view expression data of mice exposing to endotoxin (LPS) aerosol
Mouse Models C57BL/6J Airway Hyper-response HLB#102 (heritable mutant) C57BL/6J Airway Hyper-response HLB#168 C57BL/6J Airway Hyper-response HLB#170 C57BL/6J Airway Hyper-response HLB#171 (heritable mutant) C57BL/6J Airway Hyper-response HLB#173 (heritable mutant) C57BL/6J Airway Hyper-response HLB#177 C57BL/6J Airway Hyper-response HLB#178 C57BL/6J Airway Hyper-response HLB#259 C57BL/6J Airway Hyper-response HLB#260 C57BL/6J Airway Hyper-response HLB#261 C57BL/6J Airway Hyper-response HLB#262 C57BL/6J Airway Hyper-response HLB#263 C57BL/6J Airway Hyper-response HLB#264 C57BL/6J Airway Hyper-response HLB#267 C57BL/6J Airway Hyper-response HLB#268 C57BL/6J Airway Hyper-response HLB#269 C57BL/6J Airway Hyper-response HLB#270 C57BL/6J Airway Hyper-response HLB#271 C57BL/6J Airway Hyper-response HLB#362
SNPs IL10 (Innate Immunity) IL10 (SeattleSNPs) Toll-like receptor 4 Toll-like receptor 2 Toll-like receptor 9
Expression Profiles Protocol of mice exposing to endotoxin (LPS) aerosol Hybridization design of mice exposing to endotoxin (LPS) aerosol Download/view expression data of mice exposing to endotoxin (LPS) aerosol
Pulmonary Disorder
Rat Models Lung physiology of inbred and consomic rats SNPs SFTPB: Surfactant, pulmonary-associated protein B
Rat Models Lung physiology of inbred and consomic rats
SNPs SFTPB: Surfactant, pulmonary-associated protein B
Hypoxia- and Hyperoxia-induced Injury
Rat Models Cardiopulmonary function under hypoxic or hypercapnic conditions Expression Profiles Consomic SS.2BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.6BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.9BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.13BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.16BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.18BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.20BN under hypoxic or normoxic conditions (protocol, hybridization design and data) SS vs BN under hypoxic or normoxic conditions (protocol, hybridization design and data) FHH vs FHH.1BN under hypoxic or normoxic conditions (protocol, hybridization design and data)
Rat Models Cardiopulmonary function under hypoxic or hypercapnic conditions
Expression Profiles Consomic SS.2BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.6BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.9BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.13BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.16BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.18BN under hypoxic or normoxic conditions (protocol, hybridization design and data) Consomic SS.20BN under hypoxic or normoxic conditions (protocol, hybridization design and data) SS vs BN under hypoxic or normoxic conditions (protocol, hybridization design and data) FHH vs FHH.1BN under hypoxic or normoxic conditions (protocol, hybridization design and data)
Environmental Lung Diseases
Mouse Models QTL mapping of pulmonary PKC-alpha content and PKC activity Lung response to environmental stress Expression Profiles Protocol of mice exposing to chrysotile asbestos Hybridization design of mice exposing to chrysotile asbestos Download/view expression data of mice exposing to chrysotile asbestos
Mouse Models QTL mapping of pulmonary PKC-alpha content and PKC activity Lung response to environmental stress
Expression Profiles Protocol of mice exposing to chrysotile asbestos Hybridization design of mice exposing to chrysotile asbestos Download/view expression data of mice exposing to chrysotile asbestos
Clotting Disorder
Mouse Models C57BL/6J Low Fibrinogen HLB#258 SNPs FGA: Fibrinogen, A alpha peptide FGB: Fibrinogen, B beta peptide FGG: Fibrinogen, gamma peptide F2R: Coagulation factor II receptor F2RL1: Coagulation factor II - receptor like 1 F2RL2: Coagulation factor II - receptor like 2 F2RL3: Coagulation factor II - receptor like 3 F13A1: Coagulation factor XIII GP1BA: Glycoprotein Ib (platelet), alpha polypeptide PLAU: Plasminogen activator PROC: Protein C PROCR: Protein C receptor PROZ: Protein Z SERPINA5: Serine proteinase inhibitor A5 SERPINC1: Serine proteinase inhibitor C1 SERPINE1: Serine proteinase inhibitor E1 Comparative Sequence Analysis ITGA2 ITGA2B Coagulation factor receptors F2RL1/F2R/F2RL2
Mouse Models C57BL/6J Low Fibrinogen HLB#258
Immune Dysfunction
Mouse Models SNPs CSF2: Colony stimulating factor 2 CSF3: Colony stimulating factor 3 IFNG: Interferon gamma IL2 IL3 IL4 IL4R IL5 IL6 IL8 IL9 IL10 (InnateImmunity) IL10 (SeattleSNPs) IL12A IL13 IL17B IL19 IL20 IL22 STAT4: Signal transducer and activator of transcription 4 STAT6: Signal transducer and activator of transcription 6 VTN: Vitronectin Comparative Sequence Analysis IL4/IL13/IL5/CSF2/IL3 Antibody Production ARF1: ADP-ribosylation factor 1 GMCSF IFNA: Interferon alpha IFNG: Interferon gamma IL1a IL1b IL3 IL4 IL6 IL7 IL8 IL9 IL10 MCP1: Monocyte chemotactic protein 1 MIP1a: Macrophage inflammatory protein 1 alpha RANTES: Small inducible cytokine A5 RGS1: Regulator of G protein signaling 1
Mouse Models
SNPs CSF2: Colony stimulating factor 2 CSF3: Colony stimulating factor 3 IFNG: Interferon gamma IL2 IL3 IL4 IL4R IL5 IL6 IL8 IL9 IL10 (InnateImmunity) IL10 (SeattleSNPs) IL12A IL13 IL17B IL19 IL20 IL22 STAT4: Signal transducer and activator of transcription 4 STAT6: Signal transducer and activator of transcription 6 VTN: Vitronectin
Comparative Sequence Analysis IL4/IL13/IL5/CSF2/IL3
Antibody Production ARF1: ADP-ribosylation factor 1 GMCSF IFNA: Interferon alpha IFNG: Interferon gamma IL1a IL1b IL3 IL4 IL6 IL7 IL8 IL9 IL10 MCP1: Monocyte chemotactic protein 1 MIP1a: Macrophage inflammatory protein 1 alpha RANTES: Small inducible cytokine A5 RGS1: Regulator of G protein signaling 1
Abnormal Blood Cells
Mouse Models C57BL/6J Anemia HLB#222 C57BL/6J Leukocytosis HLB#18 (heritable, available) C57BL/6J Leukocytosis HLB#297 C57BL/6J Leukocytosis HLB#298 C57BL/6J Leukopenia HLB#145 C57BL/6J Leukopenia HLB#226 C57BL/6J Leukopenia with Neutrophilia HLB#141 (heritable) C57BL/6J Leukopenia with Neutrophilia HLB#142 C57BL/6J Leukopenia with Neutrophilia HLB#143 C57BL/6J Macrocytic Anemia HLB#304 C57BL/6J Neutrophilia HLB#139 C57BL/6J Neutrophilia HLB#156 (heritable, available) C57BL/6J Neutrophilia HLB#220 C57BL/6J Neutrophilia HLB#221 C57BL/6J Neutrophilia HLB#302 C57BL/6J Neutrophilia HLB#303 C57BL/6J Neutrophilia HLB#305 C57BL/6J Neutrophilia HLB#306 C57BL/6J Thrombocytopenia HLB#219 (heritable) SNPs Comparative Sequence Analysis
Mouse Models C57BL/6J Anemia HLB#222 C57BL/6J Leukocytosis HLB#18 (heritable, available) C57BL/6J Leukocytosis HLB#297 C57BL/6J Leukocytosis HLB#298 C57BL/6J Leukopenia HLB#145 C57BL/6J Leukopenia HLB#226 C57BL/6J Leukopenia with Neutrophilia HLB#141 (heritable) C57BL/6J Leukopenia with Neutrophilia HLB#142 C57BL/6J Leukopenia with Neutrophilia HLB#143 C57BL/6J Macrocytic Anemia HLB#304 C57BL/6J Neutrophilia HLB#139 C57BL/6J Neutrophilia HLB#156 (heritable, available) C57BL/6J Neutrophilia HLB#220 C57BL/6J Neutrophilia HLB#221 C57BL/6J Neutrophilia HLB#302 C57BL/6J Neutrophilia HLB#303 C57BL/6J Neutrophilia HLB#305 C57BL/6J Neutrophilia HLB#306 C57BL/6J Thrombocytopenia HLB#219 (heritable)
SNPs
Comparative Sequence Analysis
Blood Glucose
Mouse Models C57BL/6J Hyperglycemia HLB#26 C57BL/6J Hyperglycemia HLB#62 (heritable) C57BL/6J Hyperglycemia HLB#288 C57BL/6J Hypoglycemia HLB#279 C57BL/6J Hypoglycemia HLB#284 C57BL/6J Hypoglycemia HLB#337 C57BL/6J Hypoglycemia with low HDL HLB#348 C57BL/6J Hypoglycemia with high cholesterol and low HDL HLB#105 SNPs
Mouse Models C57BL/6J Hyperglycemia HLB#26 C57BL/6J Hyperglycemia HLB#62 (heritable) C57BL/6J Hyperglycemia HLB#288 C57BL/6J Hypoglycemia HLB#279 C57BL/6J Hypoglycemia HLB#284 C57BL/6J Hypoglycemia HLB#337 C57BL/6J Hypoglycemia with low HDL HLB#348 C57BL/6J Hypoglycemia with high cholesterol and low HDL HLB#105
Sleep Disorder
Mouse Models C57BL/6J Fragmented Overall Sleep Pattern with Craniofacial Defect HLB#130 (heritable) C57BL/6J Fragmented Sleep Pattern HLB#363 C57BL/6J Excessive Sleep Overall HLB#364 Expression Analysis Background of a mouse model with sleep deprivation View/download expression data of C57B/6J mice with sleep deprivation
Mouse Models C57BL/6J Fragmented Overall Sleep Pattern with Craniofacial Defect HLB#130 (heritable) C57BL/6J Fragmented Sleep Pattern HLB#363 C57BL/6J Excessive Sleep Overall HLB#364
Expression Analysis Background of a mouse model with sleep deprivation View/download expression data of C57B/6J mice with sleep deprivation
Obesity
Mouse Models C57BL/6J Obese HLB#44 (heritable) C57BL/6J Obese HLB#45 C57BL/6J Obese HLB#52 (heritable) C57BL/6J Obese HLB#80 (heritable) C57BL/6J Obese HLB#124 (heritable, available) C57BL/6J Obese HLB#131 (heritable, available) C57BL/6J Obese HLB#132 (heritable) C57BL/6J Obese HLB#147 C57BL/6J Obese HLB#162 C57BL/6J Obese HLB#163 C57BL/6J Obese HLB#165 C57BL/6J Obese HLB#181 C57BL/6J Obese HLB#196 C57BL/6J Obese HLB#197 C57BL/6J Obese HLB#198 C57BL/6J Obese HLB#199 C57BL/6J Obese HLB#230 C57BL/6J Obese HLB#231 C57BL/6J Obese HLB#273 C57BL/6J Obese (weight and % body fat) HLB#228 (heritable) C57BL/6J Obese (weight and % body fat) HLB#229 C57BL/6J Obese (weight and % body fat) HLB#342 C57BL/6J Obese (weight and % body fat) HLB#350 C57BL/6J Obese (weight and % body fat) with low bone mineral content HLB#341 C57BL/6J low bone mineral density and content HLB#370 C57BL/6J increased bone mineral density and content HLB#360 C57BL/6J increased bone mineral density and content HLB#369 SNPs Comparative Sequence Analysis ASIP
Mouse Models C57BL/6J Obese HLB#44 (heritable) C57BL/6J Obese HLB#45 C57BL/6J Obese HLB#52 (heritable) C57BL/6J Obese HLB#80 (heritable) C57BL/6J Obese HLB#124 (heritable, available) C57BL/6J Obese HLB#131 (heritable, available) C57BL/6J Obese HLB#132 (heritable) C57BL/6J Obese HLB#147 C57BL/6J Obese HLB#162 C57BL/6J Obese HLB#163 C57BL/6J Obese HLB#165 C57BL/6J Obese HLB#181 C57BL/6J Obese HLB#196 C57BL/6J Obese HLB#197 C57BL/6J Obese HLB#198 C57BL/6J Obese HLB#199 C57BL/6J Obese HLB#230 C57BL/6J Obese HLB#231 C57BL/6J Obese HLB#273 C57BL/6J Obese (weight and % body fat) HLB#228 (heritable) C57BL/6J Obese (weight and % body fat) HLB#229 C57BL/6J Obese (weight and % body fat) HLB#342 C57BL/6J Obese (weight and % body fat) HLB#350 C57BL/6J Obese (weight and % body fat) with low bone mineral content HLB#341 C57BL/6J low bone mineral density and content HLB#370 C57BL/6J increased bone mineral density and content HLB#360 C57BL/6J increased bone mineral density and content HLB#369
Comparative Sequence Analysis ASIP