Biosketch

Dr. Thomas A. Fleisher received his medical and pediatric training at University of Minnesota and went on for training in immunology at NIH in the laboratory of Dr. Thomas Waldmann. Following this training and a brief faculty position at Walter Reed Army Medical Center, he was chosen to direct the Clinical Immunology Laboratory in the Department of Laboratory Medicine at NIH. In 1998, he was selected as chief of the Department of Laboratory Medicine, where he also continues to run the immunology service within the department.

Dr. Fleisher is an adjunct professor of pediatrics at Uniformed University of the Health Sciences, and serves as consultant to the Allergy Immunology Department at Walter Reed. He served as a member of the board of directors of the American Board of Allergy and Immunology from 1991-2000 and was elected chair of the board in 1996. He also was a member of the American Board of Pediatrics. He was on the executive committee of the Clinical Immunology Society from 2003-2006, having served as its president in 2005, and was a member of the board of directors of the American Academy of Allergy, Asthma and Immunology from 2003-2007. Currently, Dr. Fleisher is President of the Robert A. Good Immunology Society.

His research interests focus on improving current assays and developing new diagnostic methods in laboratory immunology, particularly as they pertain to immune deficiency disorders. Dr. Fleisher is a member of a group of NIH medical scientists who described and characterized the autoimmune lymphoproliferative syndrome (ALPS).

Dr. Fleischer serves as a section editor for Clinical Immunology and is on the editorial board of Current Opinion in Allergy and Clinical Immunology, Clinical and Laboratory Immunology, and Communications in Clinical Cytometry. Dr. Fleisher is an editor of Clinical Immunology: Principles and Practice, the third edition of which is currently in press. Dr. Fleisher has published more than 180 peer reviewed manuscripts, reviews, and chapters.

Honors and Awards

Carl E. Arbesman Memorial Lectureship (AAAAI), 2008; Richard Farr Lecture (Colorado Allergy Society), 2003; NIH Director¹s Award, 1998; Dees Symposium Lecture (Duke University Medical School), 1998, 2005; Carl E. Arbesman Memorial Lectureship (AAAAI), 1998; Best Doctors in America,1994, 2003, 2007; Who¹s Who in America, 1993-present; Outstanding Service Medal, USPHS, 1992; Commendation Medal, USPHS, 1986

Selected Publications

BOOK CHAPTERS

Fleisher TA. Clinical and Laboratory Evaluation of a Potentially Immunoincompetent Patient. In Schrier RW, Abboud FM, Baxter JD, Fauci AS, eds. Advances in Internal Medicine. Mosby Year Book. St Louis. pp 1-30, 1996.

Fleisher TA. Evaluation of Suspected Immunodeficiency. In Schlossberg, David, ed. Current Therapy of Infectious Disease (2nd edition) Mosby. St. Louis. pp 318-320, 2001.

Fleisher TA. Methods. In Austen KF, Frank MM, Atkinson J, Cantor H, eds. Samter's Immunological Diseases (sixth edition). Lippincott Williams and Wilkins. Baltimore. pp 1229-1246, 2002.

Fleisher TA, Bleesing JJH, Marti GE. Flow cytometry. In Fleisher TA, Kotzin B, Rich RR, Schroeder H, Shearer WT, eds. Clinical Immunology: Principles and Practice (2nd edition). Harcourt, London. pp 121.1-121.12, 2002.

Fleisher TA and Bleesing JJH. Diagnostic Immunology. In Adelman DC, Corren J, Casale T, eds. Manual of Allergy and Immunology (4th edition). Lippincott Williams and Wilkins. Philadelphia. pp 441-456, 2002.

Shearer WT and Fleisher TA. The immune system: an overview. In Adkinson NF Jr, Yunginger JW, Busse WW, Bochner BS, Holgate ST, Simmons FER. Middleton’s allergy: principles and practice (sixth edition). Harcourt. Philadelphia. pp 1-14, 2003.

Fleisher TA. Autoimmune lymphoproliferative syndrome. In Leung DYM, Geha R, Sampson H, Szefler S (eds). Pediatric Allergy: Principles and Practice. Mosby, St. Louis. pp 170-175, 2003.

Bleesing JJH, Fleisher TA, Puck J. Autoimmune lymphoproliferative syndrome. In Stiehm ER ed. Immunologic Disorders Infants and Children (5th edition). WB Saunders, Philadelphia. pp 605-617, 2004.

Fleisher TA. Basic principles and clinical applications of flow cytometry. In Rodgers G and Young NS, eds. Bethesda Handbook of Clinical Hematology. Lippincott Williams & Wilkins, Baltimore. pp 415-424, 2005.

Oliveira JB, Stetler-Stevenson M, Brown M, Fleisher TA. Flow cytometry, In Young N, Gerson S, High K, eds. Clinical Hematology, Elsevier, Philadelphia. Pp 1310-1325, 2006.

JOURNAL ARTICLES

O'Mahony D. Morris JC, Quinn C, Gao W, Wilson WH, Gause B, Pittaluga S, Neelapu S, Brown M, Fleisher TA, Gulley JL, Schlom J, Nussenblatt R, Albert P, Davis, TA, Lowry I, Petrus M, Waldmann TA, Janik JE. A pilot study of CTL-4 blockade after cancer vaccine failure in patients with advanced malignancy. Clin Cancer Res. 13: 958-964, 2007.

Illei GG, Yarboro CH, Kuroiwa T, Schlimgen R, Austin HA, Tisdale JF, Chitkara P. Gleisher T. Kippel JH, Balow JE, Boumpas DT. Long term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. Rheumatology. 42:952-956, 2007.

Olivier JB, Bidere N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenard MJ. NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Nat Acad Sci (USA). 104: 8953-8958, 2007.

Rao VK, Dowdell KC, Dale JK, Dugan F, Pesnicak L, Bi LL, Hoffmann V, Penzak S, Avila NA, Fleisher TA, Puck JM, Straus SE. Pyrimethamine treatment does not ameliorate lymphoproliferation or autoimmune disease in MRL/lpr-/- mice or in patients with autoimmune lymphoproliferative syndrome. Am J Hematol. 82:1049-1055, 2007.

Uzel G, Tng E, Rosenzweig SD, Hsu AP, Shaw JP, Horwitz ME, Linton GF, Anderson SM, Kirby MR, Oliveira JB, Brown MR, Fleisehr TA, Law SK, Holland SM. Reversion mutations in patients with leukocyte adhesion deficiency type I (LAD-I). Blood. 111:211-219, 2008.