Concha M, Trujillo J, Munoz A, Bergonzoli G, Borrero I, Mora C, Gibbs CJ, Arango C; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 305 (abstract no. M.C.3030).
Johns Hopkins University, Baltimore, USA
OBJECTIVE: To identify explanatory variables for the prevalence of HTLV-I antibodies in the endemic area of Tumaco, Colombia. METHODS: During June-August of 1988, 1,077 individuals were randomly selected from an urban population of 45,594. Screening was done using Serodia particle agglutination test, and Western blot was used for confirmation of reactive samples. Criteria for seropositivity included reactivity to p19 and p24 protein bands. Categorical analysis including logistic regression was used. RESULTS: Overall prevalence rate of HTLV-I antibodies was 2.8% (95% confidence interval=1.8, 3.8). Among females prevalence (25/671, 3.7%) was significantly higher (p less than 0.02) than among males (5/406, 1.2%). Rates increased substantially with age: 4/590 (0.7%), 12/388 (3.1%) and 14/99 (14.1%), for age groups 0-19, 20-49 and greater than or equal to 50 years, respectively. HTLV-I prevalence among individuals with history of use of IV medications (i.e., injections) (13/167, 7.8%) was significantly higher (p less than 0.001) than those without such history (17/910, 1.9%). Logistic regression analysis including age in years, indicators for male gender and for injections, and their interactions yielded the following final model: Variable (regression coefficient +/- standard error; p-value), intercept (-4.145 +/- 0.341;) age-22 (0.057 +/- 0.011; less than 0.001), male (-0.427 +/- 0.579; 0.46), injections (0.705 +/- 0.414; 0.09), and (age-22)*male (-0.032 +/- 0.022; 0.15). The coefficient of age (95% C.I.) for females was 0.057 (0.035, 0.079) and for males 0.025 (-0.014, 0.063). The relative odds of seropositivity for females to males according to ages 12, 22, 32, 42 and 52 were 1.1 (0.3, 4.4), 1.5 (0.5, 4.8), 2.1 (0.8, 5.8), 2.9 (1.0, 8.5) and 4.0 (1.1., 14.7), respectively. The relative odds of injections was the same for all ages and estimated to be 2.0 (0.9, 4.6). CONCLUSIONS: Age was very strongly associated to HTLV-I infection among females. At early ages prevalence was not different between sexes, but females present a significantly higher rate than males after age 42. Sexual practices may in part explain the interaction between age and sex. History of IV administered medications was very strongly associated in the univariate analysis and although borderline significant in the multivariate analysis, it had the effect of doubling the odds of HTLV-I infection. Although temporal relationships cannot be established with this study design the use of non-disposable syringes, still a very common practice in Tumaco and a potential risk for HTLV-I transmission, should be reduced.
Publication Types:
Keywords:
- Blotting, Western
- Colombia
- Female
- HTLV-I Antibodies
- HTLV-I Infections
- Human T-lymphotropic virus 1
- Humans
- Logistic Models
- Male
- Odds Ratio
- Prevalence
- Regression Analysis
- Seroepidemiologic Studies
- epidemiology
Other ID:
UI: 102183417
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