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Grant Number: R03 HS10701
RFA/PA: PAR96-028 - AHCPR Small Project Grant Program
PI Name: SAUVE, MARY
Project Title: COGNITIVE RETRAINING IN SUDDEN CARDIAC ARREST SURVIVORS
Abstract:
SAUVE, MARY JANE
UNIVERSITY OF CALIFORNIA DAVIS, DAVIS, CA
COGNITIVE RETRAINING IN SUDDEN CARDIAC ARREST SURVIVORS
R03 HS10701-01
DESCRIPTION: Despite advances in cardiopulmonary resuscitation (CPR)
procedures, on average fewer than 30% of the victims of sudden cardiac death
(SCD) in whom CPR is attempted, live to hospital discharge. Nearly 50% of long
term survivors experience mild to severe cognitive impairments with memory the
most significantly impaired due to the global ischemia. Despite the impact of
these sequella on the survivor and their families, these patients are rarely
directed into cognitive rehabilitation. This pilot study will: 1) determine to
what extent two targeted cognitive retraining interventions can realistically
be used to improve memory function in patients with chronic anoxic brain damage
secondary to sudden cardiac arrest, and 2) assess whether improvements in
memory, if any, are accompanied by survivor and spouse/care giver reports of
improved everyday functional status. A group by trial repeated measures design
with three treatment groups (restorative, compensatory, and placebo) will be
used to assess the efficacy of the cognitive retraining strategies in 15
randomly assigned aborted sudden cardiac death survivors who have participated
in earlier studies on cognitive recovery. Baseline measures will include
standardized neuropsychological testing, survivor and spousal interviews, and
event related potentials. These measures will be repeated following completion
of the training period, and again, two months later. Each of the treatment
groups will use computers for all or part of their training. After an initial
structured training period, the intervention strategies will be carried out in
the subjects' homes. Data analyses will compare baseline to 2 months following
completion of the intervention, 2 to 4 months, and baseline to 4 months.
Fiscal Year: 2000
Department: UNIVERSITY OF CALIFORNIA DAVIS
Project Start: 02/01/2000
Project End: 01/31/2002
Accession Number: PB2003-100207 (http://www.ntis.gov)
IRG: HQER
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