Effect of Stress on Heroin-Related Memory Retrieval

This study has been completed.

First Received: September 23, 2008 No Updates Released

Sponsored by:	National Institute on Drug Dependence, China
Information provided by:	National Institute on Drug Dependence, China
ClinicalTrials.gov Identifier:	NCT00759005

Purpose

The purpose of this study is to determine whether cortisol and propranolol are effective in the modulation of stress induced heroin-related retrieval enhancement.

Condition	Intervention
Heroin Dependence Learning and Memory	Drug: propranolol and cortisol

MedlinePlus related topics: Heroin Memory

Drug Information available for: Propranolol hydrochloride Propranolol Dexpropranolol

U.S. FDA Resources

Study Type:

Interventional

Further study details as provided by National Institute on Drug Dependence, China:

Primary Outcome Measures:

Glucocorticoids enhanced heroin-related memory retrieval in abstained heroin addicts [ Designated as safety issue: Yes ]

Study Start Date:	March 2007
Study Completion Date:	September 2008
Primary Completion Date:	June 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
A, 4: Experimental	Drug: propranolol and cortisol

Eligibility

Ages Eligible for Study:	20 Years to 40 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Participants had to have met DSM-IV criteria for heroin dependence prior to abstinence.

Exclusion Criteria:

current use of any medications; current DSM-IV diagnosis of any affective, anxiety, or psychotic disorder; current dependence on any substance besides heroin and nicotine (based on DSM-IV criteria); or risk factors for untoward side effects from propranolol and cortisol (i.e., irregular heartbeats, history of cardiogenic shock, history of severe heart failure, asthma, fungal Infections, hyperlipidemia, history of hypertension, or abnormal ECG or other laboratory findings).

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00759005

Locations

China
National Institute on Drug Dependence
Beijing, China, 100191

Sponsors and Collaborators

National Institute on Drug Dependence, China

More Information

No publications provided

Study ID Numbers:	NIDD
Study First Received:	September 23, 2008
Last Updated:	September 23, 2008
ClinicalTrials.gov Identifier:	NCT00759005 History of Changes
Health Authority:	China: Peking University Research Ethics Committee

Study placed in the following topic categories:

Vasodilator Agents
Neurotransmitter Agents
Hydrocortisone
Adrenergic Agents
Cortisol succinate
Heroin Dependence
Heroin
Stress
Disorders of Environmental Origin
Cardiovascular Agents

Antihypertensive Agents
Opioid-Related Disorders
Propranolol
Mental Disorders
Substance-Related Disorders
Adrenergic beta-Antagonists
Adrenergic Antagonists
Hydrocortisone acetate
Anti-Arrhythmia Agents

Additional relevant MeSH terms:

Vasodilator Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Adrenergic Agents
Heroin Dependence
Physiological Effects of Drugs
Disorders of Environmental Origin
Cardiovascular Agents
Opioid-Related Disorders

Antihypertensive Agents
Pharmacologic Actions
Propranolol
Mental Disorders
Therapeutic Uses
Substance-Related Disorders
Adrenergic beta-Antagonists
Adrenergic Antagonists
Anti-Arrhythmia Agents

ClinicalTrials.gov processed this record on March 13, 2009