Head, RT Biochemistry Section, HIV DRP, and Head, Center of Excellence in HIV/AIDS & Cancer Virology, CCR HIV Drug Resistance Program National Cancer Institute NCI-Frederick, P.O. Box B, Building 535 Frederick, MD 21702-1201 Phone: 301-846-5256 Fax: 301-846-6013 E-mail: slegrice@ncifcrf.gov

Dr. Le Grice received his Ph.D. from the Department of Biochemistry, University of Manchester, UK, in 1976, where he studied the mechanisms of R-factor-mediated multidrug resistance in Escherichia coli.  After postdoctoral training in the United Kingdom, Germany, and the United States, he was appointed Senior Scientist in the Central Research Units of Hoffmann La Roche, Basel, Switzerland, where he worked from 1984 to 1990 evaluating HIV-1 and HIV-2 enzymes as therapeutic targets.  In 1990, he joined the faculty in the Division of Infectious Diseases, Department of Medicine, Case Western Reserve University (CWRU), Cleveland, OH.  Initially recruited as an Associate Professor of Medicine, he was awarded tenure in 1992, and in 1995 was promoted to Professor of Medicine, Biochemistry, and Oncology.  From 1994 to 1999, he served as Director of the NIH-funded CWRU Center for AIDS Research.  Dr. Le Grice joined the National Cancer Institute in 1999 as Chief of the Resistance Mechanisms Laboratory in the HIV Drug Resistance Program, Center for Cancer Research (CCR), and in 2005 was appointed to the Senior Biomedical Research Service.  In 2006, he was appointed Head of the Center of Excellence in HIV/AIDS & Cancer Virology, CCR.  He is a member of the CCR HIV and Cancer Virology faculty, Chemistry and Biology faculty, and the Steering Committee of the Molecular Targets Discovery Program.  In addition to serving on the Editorial Board of the Journal of Biological Chemistry, Dr. Le Grice has been an ad hoc (1990-1999) and permanent Study Section member of NIH AIDS review panels (2000-2004), as well as an ad hoc reviewer for several international funding agencies. Center of Excellence in HIV/AIDS & Cancer Virology, CCR Symposium on HIV/AIDS Research at the National Cancer Institute:     A Record of Sustained Excellence Le Grice Group Awards Tour of the Le Grice Laboratory Le Grice Figure from HIV DRP Home Page Openings for Postdoctoral Fellowships

Last modified: 25 November 2008