Last Updated: March 27, 2004
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Participating PGA |
| Transgenic and knockout mice to study regulation of Apoa1, Apo(a), ApoE, Abca1, Abcg5, Abcg8, Ldlr, Nkx2.5, Gata4, and Sost1 have been and are being generated |
Lipid metabolism Cardiac development |
Berkeley-PGA |
| knockout mice to study lipid metabolism or susceptibility to atherosclerosis including Ptdss2, Lmnb1, Vsp4b, Slc25a17, ATP citrate lyase, Choline kinase, alpha-chain, Srebf1, Srebf2, Agpat4, Agpat6, pon2, Nmt1, Man1, Prmt1, Scg10, FA binding protein 3, Dual secificity phosphatase, Splicing factor YT521-B. | lipid metabolism or susceptibility to atherosclerosis | BayGenomics |
| FVB mice | Benchmark set of cardiac development, maturation, aging, and sex comparison | CardioGenomics |
| FVB mouse model of hypertrophy | Pressure-overload induced cardiac hypertrophy (aortic banding) |
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| Exercise Induced Hypertrophy | ||
| Cardiac hypertrophy related to the PI3 kinase signaling pathway |
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| Hypertrophy induced by the IGF1 receptor | ||
| Rat model (Dahl salt-sensitive rats) of hypertrophy | ||
| LAD (left anterior descending) coronary artery ligation in FVB wildtype mice | Myocardial infarction | |
| Mice over-express dn-p21ras | Dilated Cardiomyopathy | |
| Csx/Nkx2.5 Mutant Embryos | Congential Heart Disease | |
| Deletion of the Nk2 specific domain of the Nkx2.5 | Multiple heart defects | |
| BALB/CJ Mice | Allegen Sensitization | HopGene |
| Long-Evans Rat | Seoul Virus | |
| C57BL/6J Mice | Hypoxia-induced Hypertophy and Hyperplasia | |
| C57BL/6J Mice | Isolated Lung Perfusion with High Tidal Volume | |
| Sprague Dawley Rat | Simvastatin effect in Hypoxic rats | |
| C57BL/6J Mice | LPS-induced Acute Lung Injury | |
| C57BL/6J Mice | Mechanical Ventilation-induced Kidney Injury | |
| C3H/HeJ Mice | Mechanical Ventilation on LPS Hypersensitive Strain | |
| DBA/2 Mice | Mechanical Ventilation on LPS Hypersensitive Strain | |
| C57BL/6J Mice | Mechanical Ventilation on LPS Hypersensitive Strain | |
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PVG.1U Rat PVG.RB Rat PVG.1A Rat |
Lung Transplant | |
| Hilltop Sprague-Dawley Rat | Pulmonary Hypersensitive Response to Hypoxia | |
| Madison Sprague-Dawley Rat | Pulmonary Hypersensitive Response to Hypoxia | |
| BALB/CJ Mice | Bleomycin Resistant | |
| C57BL/6J Mice | Bleomycin Sensitive | |
| Gelsolin KO BALB/C Mice | Pulmonary Artery Ligation | |
| Winston Rats | Mechanical Ventilation and Hyperoxia | |
| Canine | Regional Lung Stress | |
| C57BL/6J Mice | S1P Effect on LPS-induced Acute Lung Injury | |
| Mongrel Canine | Ventricular Pacing-induced Heart Failure | |
| C3H/HeJ(Tlr4-), C3H/HeOuJ Mice | Ozone and Residual Oil Fly | |
| C57BL/6(IL4-/-) Mice | Parasite (Brugia Malayi) | |
| C57BL/6J Mice | Circardium rhythm | |
| Mg delta Murine (fibrillin-1 deficient) | Septation | |
| C57BL/6J Mice | Sleep Fragmentation and Hypoxia | |
| A/J Mice | Cytokine (IL-13) | |
| CD1/BALBC (Nrf2-) Mice | Hyperoxia | |
| C57BL/6J Mice | All trans-retinoic acid and dexamethasome | |
| C57BL/6J & B6129SF2/J Mice (eNOS-/-, nNOS-/-) | Cardiac Hypertrophy | |
| Mutant mice derived from N-ethyl-N-nitrosourea (ENU) treated C57BL/6J mice |
Available mutants (confirmed heritability): hypertension (16), leukocytosis (1), thrombocytopenia (1), hypercholesterolemia with low HDL (1), obesity (2), neutrophilia (1), and leukopenia with neutrophilia (1) Strains in development (established heritability): Hypertension: Cholesterol Disorders: high HDL, high HDL with hypercholesterolemia, low HDL, hypocholesterolemia with Low HDL, change in cholesterol on atherogenic diet Blood Disorders: leukocytosis, leukopenia with neutrophilia, thrombocytopenia, macrocytic anemia Glucose Disorders: hyperglycemia Lung Function Disorders: airway hyper-response Obesity: Sleep Disorders: fragmented overall sleep pattern with craniofacial defect |
JAX-PGA |
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42-Inbred mouse strains Genotyping of inbred strains with 550 Mit markers (Click here to retrieve data based on strains and chromosomes) |
Diet-induced disease: Gallstones, atherosclerosis, and plasma lipids | Diet effects on plasma lipids and susceptibility to atherosclerosis Diet effects on blood pressure, and heart rate | Diet effects on body composition, plasma glucose, leptin, and insulin levels | Hematology, clotting, and thrombosis | Lung response to environmental stress | Lung function Diet effects on plasma phospholipid transfer protein activity, lipids, and lipoproteins | |
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| RI strains: characterize the BXD and AXB, BXA sets of RI strains | Same as above | |
| 50 mutants/yr from ENU mutagenized mice screened for above list of phenotypes | Anemia, thrombosis, lipid metabolism, blood pressure, plasma glucose, obesity | |
| ParaBiosys | ||
| 16 consomic rat strains 6 inbred, 2 outbred, and 3 parental rat strains 3 congenic rat strains |
210 physiological measurements of heart, lung, vascular, and blood function such as airway responsiveness, blood pressure regulation, lung function and renal function in response to acute and chronic hypoxia, exercise, and chronic changes in salt diet. The data will provide the functional information required to link each of the 21 rats chromosomes to cardiovascular, pulmonary, renal and blood function. Histological images are also provided. 11 Lung physiological parameters | 29 Biochemical measurements in plasma | |
PhysGen |
| C57BL/6J wt + ApoE KO | Hyperlipidemia cardiac hypertrophy (aortic banding) cardiac hypertrophy (isoproterenol response inflammation (LPS responses) |
Southwestern |
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In collaboration with JAX, TREX has examined the difference in gene expression in the following mouse models: BrainSexStrain | KidneySexStrain | LungSexStrain | Asbestos | LPS | HypertensionTissueStrain | Hypertension Acute Angiotensin Treatment HypertensionMutant | Hypoxia | SleepWake | TimedCholesterol | Trypanosoma | Tissue-Tissue | Ovalbumin |
The experimental designs, phenotyping protocols, and microarray data are posted here | TREX |
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In collaboration with PhysGen, TREX has examined the difference in heart, lung, kidney, and liver gene expression in the following rat consomic strains under hypoxia condition: SS.2BN, SS.6BN, SS.8BN, SS.9BN, SS.13BN, SS.16BN, SS.20BN, SS.YBN, BN vs SS, FHH.1BN |
The experimental designs, phenotyping protocols, and microarray data are posted here | |