O'Brien KL, McBrien M, Louis A, Desormeaux J, Coberly J, Ruff A; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 533 (abstract no. PO-B37-2389).
Johns Hopkins Univ., Baltimore, MD.
OBJECTIVE: To determine the risk and severity of complications following BCG vaccination among HIV infected and HIV uninfected children. METHODS: 121 infants born to HIV (+) and 174 infants born to HIV (-) mothers were immunized at birth with BCG vaccine (0.1-0.125 mL, Pasteur). The infants were followed until 15 months of age with monthly physical examinations and blood collection every 3 months. BCG complications were classified as moderate (axillary abscess, fistulization) or mild (lymphadenitis, vaccine site ulceration). RESULTS: The rate of all complications in HIV infected infants was slightly higher than the rate in uninfected infants [21.4% vs 11.5%, Fisher test: p = 0.19]. Infants born to HIV infected women had a slightly higher rate of moderate BCG complications as compared to infants born to HIV uninfected women [5.4% vs 1.9%; Fisher test: p = 0.11]. No infants had a severe complication. All complications were seen between 1 and 7 months of age except for one HIV (-) child who developed lymphadenitis at 14 months of age. After reducing the dose of BCG to 0.05 mL, no further complications were noted. CONCLUSIONS: This study confirms previous reports that BCG vaccine is safe in HIV infected infants even in the setting of the inadvertent administration of 2 to 2.5 times the recommended dose of Pasteur BCG vaccine. Both HIV infected and uninfected infants tolerated this dose well without any cases of severe complication. All complications resolved spontaneously without treatment except for an HIV (-) child who received INH for recurrent fistulization.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- BCG Vaccine
- Child
- Disease Progression
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Infant
- Lymphadenitis
- Mycobacterium bovis
- therapy
Other ID:
UI: 102205405
From Meeting Abstracts