Huang YQ, Li JJ, Nicolaides A, Zhang WG, Kien AE; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 145.
New York University Medical Center, New York, NY.
Several growth factors and cytokines including bFGF, IL-1 IL-6 and oncostatin M have been shown to be involved in the proliferation of KS-derived cells in vitro. However, their relevance to the pathogenesis of KS in vivo remains to be elucidated. The expression of growth factors (aFGF, bFGF, FGF3 (Int-2), FGF-4 (kFGF), FGF5, and FGF6) receptors (flg and bek) as well as cytokines: (IL-1 , IL-6, and oncostatin M) were examined in fresh biopsies of KS skin lesions, normal skin from distant sites and PBMC from patients with AIDS-KS by RT-CPR, RNA blot and immunostaining methods. Greater expression of bFGF was detected in normal skin than in KS tumors and the expression of IL-1 was detected in only 1 of 10 KS specimens examined. The expression of oncostatin M was observed in the KS and uninvolved skin specimens as well as the PBMC from patients with AIDS-KS and from healthy, HIV-1 negative individuals. However, mutated FGF3 was found to be expressed in 21 of 38 (52%) fresh KS specimens but only 1 of 12 normal skin biopsies. The expression of FGF5 was detected in 4 of 6 KS tumors but not detected in normal skin.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Carrier Proteins
- Cytokines
- Fibroblast Growth Factor 2
- Fibroblast Growth Factors
- Gene Expression
- Growth Substances
- HIV-1
- Humans
- In Vitro
- Interleukin-1
- Interleukin-6
- Oncostatin M
- Peptides
- Sarcoma, Kaposi
- Skin
- Skin Neoplasms
- genetics
Other ID:
UI: 102214461
From Meeting Abstracts