Bikle DD, Currier PA, Morey-Holton ER, Doty SB, Halloran BP.
ASGSB Bull. 1993 Oct; 7: 36.
Veterans Administration Medical Center, San Francisco, CA.
The contribution of bone resorption to the deficit in bone mass induced by skeletal unloading in the growing rat was studied by injecting 0.1 mg P/kg alendronate (AHBP), an inhibitor of bone resorption, or vehicle, two consecutive days before hindlimb unloading. All groups gained approximately 30 g body weight during the 9 d experiment. Tibia fat-free weight (FFW) increased 25% in saline vehicle controls (V), 10% in V unloaded (VU), 45% in AHBP controls (A), and 37% in AHBP unloaded (AU); all values were significantly different from each other. Cancellous proximal tibia FFW (PT) increased over baseline (V=17%, VU=0%, A=79%, AU=73%); only A vs AU was similar. Tibia cortical FFW (CT) was similar in all groups. Calcium values paralled bone weights. Matrix formation, i.e. 3H-proline levels, in PT and CT, decreased both with unloading and AHBP. PT bone mineralization, i.e. 45Ca levels, increased with AHBP and decreased in VU vs V but not AU vs A; CT 45Ca was similar in VU and V, but lower in AHBP and in AU vs A. These data suggest that AHBP prevents the relative loss of cancellous bone in growing rats during skeletal unloading through inhibition of bone resorption, but does so by adversely altering bone chemistry and growth.
Publication Types:
Keywords:
- Alendronate
- Animals
- Body Weight
- Bone Resorption
- Bone and Bones
- Calcification, Physiologic
- Calcium
- Calcium Radioisotopes
- Hindlimb Suspension
- Rats
- Tibia
- NASA Center ARC
- NASA Discipline Musculoskeletal
- NASA Discipline Number 00-00
- NASA Discipline Number 40-40
- NASA Program Flight
- NASA Program Space Biology
- Non-NASA Center
Other ID:
UI: 102212846
From Meeting Abstracts