Gyorkey F, Gyorkey P, Sinkovics JG, Szakacs JE, Gergely S; National Conference on Human Retroviruses and Related Infections.

Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 95.

Cancer Institute, Tampa, FL.

In 1959, Dr. Leon Dmochowski assigned to one of us (JGS) the task of inoculating thousands of newborn mice with human tumor extracts or supernatant fluids of primary cultures thereof. While he observed retrovirus particles in some of the original specimens, no increased incidence of tumors and no viral isolates resulted (Research Report MD Anderson Hospital 1960 pp 55-58; Exp Med Surg 20/4;277-298, 1962). Since then in laboratories other than ours, HTLV-I & II and HIV-1 & 2 have been isolated. We continue to observe rare budding retrovirus particles in lymphocytes and keratinocytes in SLE; in hairy leukemia cells; in Reed- Sternberg cells of Hodgkin's disease (HD); in myeloma cells, in Kaposi sarcoma cells; and in other soft tissue and osseous sarcina cells. With in situ hybridization and immunoelectron microscopy indicate that these observed retrovirus particles do not cross react with known human retroviruses. In laboratories other than ours, retroviral expressions were detected in collagen diseases including SLE and multiple sclerosis. It is known that the genus Homo harbors endogenous replication-defective retroviral genomic sequences. Could these genomic sequences occasionally recombine to produce mature virions? Could recombinants between defective endogenous and exogenous retroviruses arise? One study (Crit Rev Immun 11:33-63, 1991), indicates as if a human retrovirus in HD served as an envelope donor to a defective spleen focus forming mouse leukemia virus. Herpes viruses alone can induce malignant lymphoproliferative diseases in animals (Marek's avian leukemia-lymphoma; lymphomas of marmoset monkeys). We prefer not to accept the Epstein-Barr virus as the causative agent of Burkitt's lymphoma, hairy cell leukemia or HD, but consider retroviral etiology in which the herpes-type virus contributes later to, but does not initiate the malignant transformation. Retro (lenti) viral etiology of certain human diseases should remain in the focus of research.

Publication Types:

• Meeting Abstracts

Keywords:

• Animals
• Base Sequence
• Haplorhini
• Herpesvirus 4, Human
• Hominidae
• Human T-lymphotropic virus 2
• Humans
• Infant, Newborn
• Leukemia
• Leukemia, Hairy Cell
• Lymphoma
• Mice
• Retroviridae
• Retroviridae Infections
• Virion
• genetics

Other ID:

• 95921252

UI: 102214192

From Meeting Abstracts