Melchior JC, Raguin G, Rigaud D, Bouvet E, Matheron S, Boulier A, Vilde JL, Vachon F, Apfelbaum M; International Conference on AIDS.
Int Conf AIDS. 1991 Jun 16-21; 7: 293 (abstract no. W.B.2445).
Hospital & University Bichat-C. Bernard, Paris, France
Energy expenditure is well known to be increased during various infections. In a previous work, we reported that the resting energy expenditure (REE) expressed per kg of fat free mass (FFM) was 12% higher in HIV patients than in healthy subjects (AJCN 1991;53:437-441). In HIV patients, the search for intercurrent evolutive infection is expensive and time consuming. The aim of the study was to determine if REE could be a marker of the presence of an evolutive systemic infection in HIV patients with body temperature less than 38 degrees C. In 164 HIV patients (142 AIDS, 22 ARC) we measured REE (indirect calorimetry) and FFM (anthropometry) and the results were analysed as to the presence (n=36) or the absence (n=128) of an evolutive systemic infection (mycobacterial infection n=14, pneumocystosis n=3, CMV infection n=4, toxoplasmosis n=5, bacterial pneumoniae n=4, other bacterial infections n=7). Expressed per kg of FFM, REE of stable patients was 36.4+/-3.9 vs 49.5+/-7.2 kcal/kgFFM/day in patients with acute evolutive infection (p less than 0.0001). The best threshold value of REE to disciminate between stable state and acute systemic infection was 42.3 kcal/kgFFM/day. Using this cut off point, sensibility was 0.92, specificity was 0.93 with 93% of patients well classified. We suggest that measurement of REE, a non invasive method, could be a simple and economic investigation aiming to suspect an evolutive systemic infection.
Publication Types:
Keywords:
- AIDS-Related Complex
- Acquired Immunodeficiency Syndrome
- Anthropometry
- Calorimetry, Indirect
- Communicable Diseases
- Energy Metabolism
- HIV Infections
- HIV Seropositivity
- Humans
- Infection
- Rest
- Sepsis
Other ID:
UI: 102193075
From Meeting Abstracts