Lipson SM, Ciamician Z, Falk L, Shepp DH, Kaplan MH; American Society for Microbiology. General Meeting.
Abstr Gen Meet Am Soc Microbiol. 1996 May 19-23; 16 (abstract no. C-88).
North Shore University Hospital-NYU School of Medicine, Manhasset, NY.
120 AIDS patients not on antiviral therapy, were tested by a standardized CMV-Ag assay in an attempt to correlate viral [CMV] load with severe organ disease. CMV organ specific disease was present in 6/15 (40 percent) with greater than 10 fluorescent focus units (FFU's) and 5/10 (50 percent) with greater than 50 FFU's, compared to 0/105 (0 percent) and 1/110 (.9 percent) with less than or equal to 10 and less than or equal to 50 FFU's, among patients tested using polymorphonuclear leukocyte (PMNL) preparations of 4 X 10 to the 5th power cells/spot, respectively (p is less than 0.001). Viral load was monitored through sequential testing of symptomatic patients undergoing ganciclovir, foscarnet, or combination therapy. Among 10 patients started on individual or combination drug therapy, viral load was markedly reduced in 7, within 2 weeks. Three patients (2 deceased) showed no decrease in viral load. The CMV antigenemia assay served as a marker for organ specific disease in AIDS patients. Monitoring of viral load using the CMV-Ag assay may also be useful in the tracking of drug efficacy and screening for potential resistant strains.
Publication Types:
Keywords:
- Antiviral Agents
- Biological Assay
- Biological Markers
- Cytomegalovirus
- Cytomegalovirus Infections
- Cytomegalovirus Retinitis
- Foscarnet
- Ganciclovir
- Humans
- Viral Load
- analysis
- drug effects
- transplantation
Other ID:
UI: 102222965
From Meeting Abstracts