100107 |
cd02440 |
AdoMet_MTases |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.). |
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ... |
true |
false |
true |
107 |
6e-09 |
55.90 |
96.26 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 42 TLADIGTATAVVPVRLAADPAmaqWRFVGVDLDPAMLDEGVpRIARLGLAGRVALKVGDALALPFD-DASLSMVVSRATL 120
cd02440 1 RVLDLGCGTGALALALASGPG---ARVTGVDISPVALELAR-KAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPL 76
|
90 100
....*....|....*....|....*..
local 121 HHLPDKALS-LAEMFRVLRPGGVGVVH 146
cd02440 77 HHLVEDLARfLEEARRLLKPGGVLVLT 103
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
0 |
32408 |
COG2226 |
UbiE |
Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism] |
Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism] |
false |
false |
false |
238 |
5e-17 |
83.01 |
57.56 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 9 ADDYDRFANEALAPWDALFIARIRELARALPPGTLADIGTATAVVPVRLAAdpAMAQWRFVGVDLDPAMLDEGVPRIARL 88
COG2226 21 AKKYDLMNDLMSFGLHRLWRRALISLLGIKPGDKVLDVACGTGDMALLLAK--SVGTGEVVGLDISESMLEVAREKLKKK 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
local 89 GLAGrVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDM 148
COG2226 99 GVQN-VEFVVGDAENLPFPDNSFDAVTISFGLRNVTDIDKALKEMYRVLKPGGRLLVLEF 157
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
-1 |
116826 |
pfam08241 |
Methyltransf_11 |
Methyltransferase domain |
Methyltransferase domain |
false |
false |
false |
95 |
1e-14 |
74.64 |
95.79 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 45 DIGTATAVVPVRLAADPAmaqWRFVGVDLDPAMLDegvpRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLP 124
pfam08241 2 DVGCGTGLLTEALARLPG---ARVTGVDLSPEMLA----LARKRAPEDGLTFVVGDAEDLPFPDESFDVVVSSEVLHHLP 74
|
90
....*....|....*...
local 125 DKALSLAEMFRVLRPGGV 142
pfam08241 75 DPEKALREIARVLKPGGK 92
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
-1 |
110227 |
pfam01209 |
Ubie_methyltran |
ubiE/COQ5 methyltransferase family |
ubiE/COQ5 methyltransferase family |
false |
false |
false |
233 |
3e-11 |
63.23 |
45.49 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 38 LPPGTLADIGTATAVVPVRLAaDPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAgRVALKVGDALALPFDDASLSMVVSR 117
pfam01209 46 KRGNKFLDVAGGTGDWTFGLS-DSAGSSGKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTIS 123
|
90 100
....*....|....*....|....*...
local 118 ATLHHLPDKALSLAEMFRVLRPGGVGVV 145
pfam01209 124 FGLRNFPDYLKVLKEAFRVLKPGGRVVC 151
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
-1 |
100442 |
PRK00216 |
ubiE |
ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed |
ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed |
false |
false |
false |
236 |
5e-10 |
59.80 |
46.61 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 32 RELARALPPGTLADIGTATAVVPVRLAADpAMAQWRFVGVDLDPAMLDEGvprIARLGLAGRVALKVGDALALPFDDASl 111
PRK00216 44 IKWLGVKPGDKVLDLACGTGDLAIALAKA-VGPTGEVVGLDFSEGMLAVG---RERLPDAGLVEFVQGDAEALPFPDNS- 118
|
90 100 110
....*....|....*....|....*....|....*...
local 112 smvVSRAT----LHHLPDKALSLAEMFRVLRPGGVGVV 145
PRK00216 119 ---FDAVTiafgLRNVPDIDKALREMYRVLKPGGRLVI 153
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
-1 |
116827 |
pfam08242 |
Methyltransf_12 |
Methyltransferase domain |
Methyltransferase domain |
false |
false |
false |
98 |
2e-09 |
57.77 |
97.96 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 45 DIGTATAVVPVRLAadPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLP 124
pfam08242 2 DIGCGTGTLLRALL--EALPGLEYTGVDISPAALEAAAERLAALGLLDAVRVRLDVLDAIDLDLGSFDVVVASNVLHHLE 79
|
90
....*....|....*...
local 125 DKALSLAEMFRVLRPGGV 142
pfam08242 80 DPRAVLRNIRRLLKPGGV 97
|
|
cl09931 |
127283 |
NADB_Rossmann |
Rossmann-fold NAD(P)(+)-binding proteins |
Rossmann-fold NAD(P)(+)-binding proteins |
-1 |
103347 |
PRK08317 |
PRK08317 |
hypothetical protein; Provisional |
hypothetical protein; Provisional |
false |
true |
false |
241 |
5e-16 |
79.63 |
50.62 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 27 FIARIRELARAL----PPGTLADIGTATAVVpVRLAADPAMAQWRFVGVDLDPAMLDEGVPRIARLGLagRVALKVGDAL 102
PRK08317 3 QIRRYRERTFELlapqPGERVLDIGCGPGND-ARALADRVGPEGRVVGIDRSEAMLALARERAANLGL--NVEFVLGDAQ 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
local 103 ALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHD 147
PRK08317 80 GLPFPDESFDAVRSDRVLQHLADPSRALAEIARVLRPGGRVVVLD 124
|
|
|
|
|
|
|
-1 |
105449 |
PRK11873 |
arsM |
arsenite S-adenosylmethyltransferase; Reviewed |
arsenite S-adenosylmethyltransferase; Reviewed |
false |
true |
false |
264 |
1e-08 |
55.03 |
33.71 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 69 VGVDLDPAMLdEGVPRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDM 148
PRK11873 103 IGVDMTPEML-AKARANARKAGYTNVEFRLGEIEALPLADGSVDVIISNCVINLSPDKEKVFREAFRVLKPGGRFAISDV 181
|
90
....*....|
local 149 --RRDAPPAL 156
PRK11873 182 vlTGELPEEI 191
|
|
|
|
|
|
|
-1 |
32409 |
COG2227 |
UbiG |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism] |
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme metabolism] |
false |
true |
false |
243 |
1e-04 |
41.42 |
51.44 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 27 FIARIRELARALPPGTLADIGTATAVVPVRLAADPAmaqwRFVGVDLDPAMLDEGVPRIARLGLAgrVALKVGDALALPF 106
COG2227 47 YIREVARLRFDLPGLRVLDVGCGGGILSEPLARLGA----SVTGIDASEKPIEVAKLHALESGVN--IDYRQATVEDLAS 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
local 107 DDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPPALL 157
COG2227 121 AGGQFDVVTCMEVLEHVPDPESFLRACAKLVKPGGILFLSTINRTLKAYLL 171
|
|
|
|
|
|
|
-1 |
32411 |
COG2230 |
Cfa |
Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane] |
Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope... |
false |
true |
false |
283 |
4e-04 |
39.86 |
58.66 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 8 PADDYDRFANEALAPWDALF-----------IARIRELARA--LPPG-TLADIGTATAVVPVRLAADPAMaqwRFVGVDL 73
COG2230 27 SNDFYRLFLDPSMTYSCAYFedpdmtleeaqRAKLDLILEKlgLKPGmTLLDIGCGWGGLAIYAAEEYGV---TVVGVTL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 74 DPAMLDEGVPRIARLGLAGRVALKVGD--ALALPFDdaslsMVVSRATLHHLPDKALS--LAEMFRVLRPGGVGVVHDM- 148
COG2230 104 SEEQLAYAEKRIAARGLEDNVEVRLQDyrDFEEPFD-----RIVSVGMFEHVGKENYDdfFKKVYALLKPGGRMLLHSIt 178
|
170
....*....|....
local 149 RRDAPPALLERFTQ 162
COG2230 179 GPDQEFRRFPDFID 192
|
|
|
|
|
|
|
-1 |
104423 |
PRK10258 |
PRK10258 |
biotin biosynthesis protein BioC; Provisional |
biotin biosynthesis protein BioC; Provisional |
false |
true |
false |
251 |
5e-04 |
39.41 |
25.90 |
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
local 72 DLDPAMLDEgvpriARLGLAGRVALkVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGV 142
PRK10258 71 DLSPPMLAQ-----ARQKDAADHYL-AGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGV 135
|
|
|
|
|
|
|
-1 |
30846 |
COG0500 |
SmtA |
SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only] |
SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and... |
false |
true |
false |
257 |
6e-04 |
39.44 |
76.26 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 1 MLLKNLRPADDYDRFANEALAPWDALFIARIRELARALPPGTLADIGTATAVVPVRLAADPAMAQWRFVGVDLDPAMLDE 80
COG0500 8 LLSRILELYDRLAELLDAFLLLAEELLDLLLVLRLLRLLPGGLGVLDIGCGTGRLALLARLGGRGAYVVGVDLSPEMLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 81 GVPRIARLGLaGRVALKVGDAL--ALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPPALLE 158
COG0500 88 ARARAEGAGL-GLVDFVVADALggVLPFEDSASFDLVISLLVLHLLPPAKALRELLRVLKPGGRLVLSDLLRDGLLEGRL 166
|
170 180 190
....*....|....*....|....*....|....*..
local 159 RFTQMRAAANYPPTHLEEKVTLDEARELVAAAGLAEH 195
COG0500 167 AALLGFGDPVLERGDILLELEALLRLELLDLEELLGL 203
|
|
|
|
|
|
|
-1 |
102625 |
PRK06922 |
PRK06922 |
hypothetical protein; Provisional |
hypothetical protein; Provisional |
false |
true |
false |
679 |
7e-04 |
39.17 |
22.09 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 10 DDYDRFANEALAPWDALFIARI-RELARALPPGTLADIGTATAVVPVRLAADPAMAqwRFVGVDLDPAMLDEGVPRIARL 88
PRK06922 390 DAYDRFHNEEVYLEHMNSSADDkRIILDYIKGDTIVDVGAGGGVMLDMIEEETEDK--RIYGIDISENVIDTLKKKKQNE 467
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
local 89 GLAGRValKVGDALALP--FDDASLSMVVSRATLHHLPDK-------------ALSLAEMFRVLRPGGVGVVHD 147
PRK06922 468 GRSWNV--IKGDAINLSssFEKESVDTIVYSSILHELFSYieyegkkfnheviKKGLQSAYEVLKPGGRIIIRD 539
|
|
|
|
|
|
|
-1 |
33879 |
COG4122 |
COG4122 |
Predicted O-methyltransferase [General function prediction only] |
Predicted O-methyltransferase [General function prediction only] |
false |
true |
false |
219 |
0.004 |
36.43 |
84.02 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 13 DRFANEALAPWDALFIAR-IRELARALPPGTLADIGTATAVVPVRLAADpAMAQWRFVGVDLDPAMLDEGVPRIARLGLA 91
COG4122 32 EEFARENGVPIIDPETGAlLRLLARLSGPKRILEIGTAIGYSALWMALA-LPDDGRLTTIERDEERAEIARENLAEAGVD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 92 GRVALKV-GDALAL--PFDDASLSMVVSRATLHHLPDkalSLAEMFRVLRPGGVGVVHDMRR------DAPPALLERFTQ 162
COG4122 111 DRIELLLgGDALDVlsRLLDGSFDLVFIDADKADYPE---YLERALPLLRPGGLIVADNVLFggrvadPSIRDARTQVRG 187
|
170 180
....*....|....*....|....*...
local 163 MRAAANYPPTHLEEKVTLDEARELVAAA 190
COG4122 188 VRDFNDYLLEDPRYDTVLLPLGDGLLLS 215
|
|
|
|
|
|
|
-1 |
33880 |
COG4123 |
COG4123 |
Predicted O-methyltransferase [General function prediction only] |
Predicted O-methyltransferase [General function prediction only] |
false |
true |
false |
248 |
0.005 |
36.38 |
63.71 |
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 24 DALFIARireLARALPPGTLADIGTATAVVPVRLAADPAMAQwrFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALA 103
COG4123 32 DAILLAA---FAPVPKKGRILDLGAGNGALGLLLAQRTEKAK--IVGVEIQEEAAEMAQRNVALNPLEERIQVIEADIKE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
local 104 L--PFDDASLSMVVS----------------RATLHHLPDKALS--LAEMFRVLRPGG-VGVVHdmrrdaPPALLERFTQ 162
COG4123 107 FlkALVFASFDLIICnppyfkqgsrlnenplRAIARHEITLDLEdlIRAAAKLLKPGGrLAFVH------RPERLAEIIE 180
|
....*....
local 163 MRAAANYPP 171
COG4123 181 LLKSYNLEP 189
|
|
|
|
|
|
|
-1 |