100104 |
cd00590 |
RRM |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (... |
true |
false |
true |
74 |
7e-10 |
59.53 |
100.00 |
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24661022 167 TIFVSG--NKVTEDFLKKTFNDYGTIVNVSM---EIEKSRG--FVSFAKPESADRAIAEIHGKNVNGINLQVQL 233
cd00590 1 TLFVGNlpPDVTEEDLRELFSKFGKVESVRIvrdKDTKSKGfaFVEFEDEEDAEKALEALNGKELGGRPLRVEF 74
|
|
cl02586 |
121421 |
RRM |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (... |
0 |
90510 |
smart00360 |
RRM |
RNA recognition motif; |
RNA recognition motif; |
false |
false |
false |
73 |
3e-08 |
54.08 |
100.00 |
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24661022 167 TIFVSG--NKVTEDFLKKTFNDYGTIVNVSMEIEK---SRG--FVSFAKPESADRAIAEIHGKNVNGINLQVQ 232
smart00360 1 TLFVGNlpPDTTEEDLRELFSKFGKVVSVRIVRDKdtkSKGfaFVEFEDEEDAEKAIEALNGKELGGRPLRVK 73
|
|
cl02586 |
121421 |
RRM |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (... |
-1 |
109144 |
pfam00076 |
RRM_1 |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
false |
false |
false |
70 |
2e-07 |
51.45 |
94.29 |
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24661022 168 IFVSG--NKVTEDFLKKTFNDYGTIVNVSM---EIEKSRG--FVSFAKPESADRAIAEIHGKNVNG 226
pfam00076 1 LFVGNlpPDTTEEDLKDLFSKFGPIESIKIvrdETGRSKGfaFVEFEDEEDAEKALEALNGKELGG 66
|
|
cl02586 |
121421 |
RRM |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). |
RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (... |
-1 |