Agency for Toxic Substances and Disease Registry

Toxicological Profile Information Sheet

By Congressional mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) produces "toxicological profiles" for hazardous substances found at National Priorities List (NPL) sites. These hazardous substances are ranked based on frequency of occurrence at NPL sites, toxicity, and potential for human exposure. Toxicological profiles are developed from a priority list of 275 substances. ATSDR also prepares toxicological profiles for the Department of Defense (DOD) and the Department of Energy (DOE) on substances related to federal sites.

So far, 239 toxicological profiles have been published or are under development as "finals" or "drafts for public comment"; 209 profiles were published as finals; 74 profiles have been updated. Currently, 22 profiles are being revised based on public comments received and another 8 are being developed as public comment drafts.  These profiles cover more than 250 substances.

Toxicological profiles are developed in two stages:

(1) DRAFTS: The toxicological profiles are first produced as drafts. ATSDR announces in the Federal Register the release of these draft profiles for a 90-day public comment period. Request draft toxicological profiles from ATSDR's Division of Toxicology.

(2) FINALS: After the 90-day comment period, ATSDR considers incorporating all comments into the documents. ATSDR finalizes the profiles and the National Technical Information Service (NTIS) distributes them.

Congress requires ATSDR (1) to provide toxicological profiles to state health and environmental agencies and (2) to make them available to other interested parties. The Division of Toxicology (DT) has a mailing list, which is updated and verified yearly, of groups and individuals who get free copies of both draft and final profiles; these include health professionals at federal, state, and local levels; academicians; nonprofit/environmental groups; members of the public involved with Superfund sites; and parties with special needs (considered case-by-case).

If you don't qualify for free copies, you may request final profiles from NTIS for a fee.

NTIS distributes finalized toxicological profiles for a fee. For more information, contact:

National Technical Information Service
5285 Port Royal Road
Springfield, Virginia 22161
800-553-6847 or 703-605-6000
NTIS Web Site: www.ntis.gov

How to contact ATSDR for more information on tox profiles or ToxFAQs

Division of Toxicology (DT), Agency for Toxic Substances and Disease Registry
1600 Clifton Road, Mailstop E-29
Atlanta, GA 30333

ATSDR's toll free number:     1-888-42-ATSDR (1-888-422-8737)
DT Docket: Phone:               404-639-6322;  Fax 404-639-6324
DT Main Switchboard:         404-639-6300;  Fax 404-639-6315

Or you may send any questions or requests to the ATSDR Information Center

For more information

You may call ATSDR's toll free number at 1-888-42-ATSDR (1-888-422-8737) to reach ATSDR personnel for technical assistance Monday through Friday, during the hours of  9:00 am to 5:30 pm, EST.  After hours you may leave a voice mail message and a technical information specialist will return your call the next business day.

Public Health Statements and ToxFAQs^tm for many of the tox profiles and other information are also available on the Internet.

Home Page

-A-

• Acetone (PB/95/100095/AS)
• Acrolein (PB/91/180307/AS)
• Acrylonitrile (PB/91/180489/AS)
• Aldrin/Dieldrin (Update) (PB/93/182368/AS)
• Aluminum (PB/93/110633/AS)
• Ammonia (PB/91/180315/AS)
• Antimony (PB/93/110641/AS)
• Arsenic (Update) (PB/93/182376/AS)
• Asbestos (Update) (PB/95-264305)
• Automotive gasoline (PB/95/264206/AS) *

-B-

• Barium (PB/93/110658/AS)
• Benzene (Update) (PB/98/101157/AS)
• Benzidine (Update) (PB/95/264313)
• Benzo(a)anthracene (PB/90/247669/AS)
• Benzo(a)pyrene (PB/90/258245/AS)
• Benzo(b)fluoranthene (PB/90/247651/AS)
• 2,3-Benzofuran (PB/93/110666/AS)
• Beryllium (Update) (PB/93/182392/AS)
• Bis(2-chloroethyl)ether (PB/90/168683/AS)
• Bis(chloromethyl)ether (PB/90/168691/AS)
• Boron (PB/93/110674/AS)
• Bromodichloromethane (PB/90/167461/AS)
• Bromoform (PB/91/180323/AS)
• Bromomethane (PB/93/110682/AS)
• 1,3-Butadiene (PB/93/110690/AS)
• 2-Butanone (PB/93/110708/AS)
• 2-Butoxyethanol & 2-Butoxyethanol acetate (PB/99/102527/AS) *

-C-

• Cadmium (Update) (PB/93/182418/AS)
• Carbon disulfide (Update) (PB/97/121073/AS)
• Carbon tetrachloride (Update) (PB/95/100103/AS)
• Chlordane (Update) (PB/95/100111/AS)
• Chlorfenvinphos (PB/98/101116/AS)
• Chlorobenzene (PB/91/180505/AS)
• Chlorodibenzofurans (PB/95/100129/AS)
• Chlorodibromomethane (PB/91/180323/AS)
• Chloroethane (Update)
• Chloroform (Update) (PB/98/101140/AS)
• Chloromethane (Update)
• Chlorpyrifos (PB/98/103088/AS)
• Chromium (Update) (PB/93/182434/AS)
• Chrysene (PB/90/247644/AS)
• Cobalt (PB/93/110724/AS)
• Copper (PB/91/180513/AS)
• Creosote (Update) (PB/97/121024/AS)
• Cresols (PB/93/110732/AS)
• Cyanide (Update) (PB/98/101207/AS)

-D-

• 4,4'-DDT, DDE,DDD (Update) (PB/95/100137/AS)
• Diazinon (PB/97/121107/AS)
• Dibenzo(a,h)anthracene (PB/90/247636/AS)
• Dibromochloropropane (PB/93/110906/AS)
• 1,2-Dibromoethane (PB/93/110740/AS)
• 1,4-Dichlorobenzene (Update)
• 3,3'-Dichlorobenzidine (Update)
• 1,1-Dichloroethane (PB/91/180539/AS)
• 1,2-Dichloroethane (Update) (PB/95/100145/AS)
• 1,1-Dichloroethene (Update) (PB/95/100152/AS)
• cis-, trans- 1,2-Dichloroethene (Update)(PB/97/121081/AS)
• 2,4-Dichlorophenol (PB/93/110757/AS)
• 1,2-Dichloropropane (PB/90/182122/AS)
• 1,3-Dichloropropene (PB/93/110765/AS)
• Dichlorvos (PB/98/101124/AS)
• Di(2-ethylhexyl)phthalate (Update) (PB/93/182400/AS)
• Diethyl phthalate (PB/95/264214/AS) *
• Diisopropylmethylphosphonate (PB/99/102535/AS) *
• Di-n-butylphthalate (PB/91/180521/AS)
• 1,3-Dinitrobenzene/1,3,5-Trinitrobenzene (PB/95/264289/AS) *
• Dinitrocresols (PB/95/264321)
• Dinitrophenols (PB/95/264339)
• 2,4- & 2,6-Dinitrotoluene (Update)
• Di-n-octylphthalate (PB/98/101033/AS) *
• Dioxin (Update)
• 1,2-Diphenylhydrazine (PB/91/180356/AS)
• Disulfoton (PB/95/264347)

-E-

• Endosulfan (PB/93/182558/AS)
• Endrin/Endrin aldehyde (Update) (PB/97/121040/AS)
• Ethylbenzene (PB/91/180372/AS)
• Ethylene glycol and Propylene glycol (PB/98/101108/AS) *
• Ethylene oxide (PB/91/180554/AS)

-F-

• Fluoride, Hydrogen Fluoride, and Fluorine (PB/93/182566/AS)
• Fuel oils (PB/95/264222/AS) *

-G-

None Available

Return to finalized index

-H-

• Heptachlor/Heptachlor epoxide (Update) (PB/93/182467/AS)
• Hexachlorobenzene (Update) (PB/97/121065/AS)
• Hexachlorobutadiene (PB/95/100160/AS)
• Hexachlorocyclohexanes (Update) (PB/95/100178/AS)
• Hexachloroethane (PB/98/101041/AS) *
• Hexamethylene diisocyanate (PB/99/102543/AS) *
• 2-Hexanone (PB/93/110773/AS)
• HMX (PB/98/101058/AS) *
• Hydraulic fluids (PB/98/101066/AS) *
• Hydrazines (PB/98/101025/AS) *

-I-

• Isophorone (PB/90/180225/AS)

-J-

•  Jet fuels - JP-4 & JP-7 (PB/95/264230/AS) *
•  Jet fuels - JP-5 & JP-8 (PB/99/102550/AS) *

-K-

None Available

Return to finalized index

-L-

• Lead (Update) (PB/93/182475/AS)

-M-

• Manganese (PB/93/110781/AS)
• MBOCA (PB/95/100186/AS)
• Mercury (Update) (PB/95/100194/AS)
• Methoxychlor (PB/95/100202/AS)
• Methylene chloride (Update) (PB/93/182483/AS)
• Methylenedianiline (PB/99/102568/AS) *
• Methyl mercaptan (PB/93/110799/AS)
• Methyl parathion (PB/93/110807/AS)
• Methyl t-butyl ether (PB/97/121016/AS)
• Mineral-based crankcase oil (PB/98/101074/AS) *
• Mirex and Chlordecone (PB/95/264354)
• Mustard gas (PB/93/110815/AS)

-N-

• Naphthalene/1-methylnaphthalene/2-methylnaphthalene (Update) (PB/95/264362)
• Nickel (Update) (PB/98/101199/AS)
• Nitrobenzene (PB/91/180398/AS)
• Nitrophenol (PB/93/110823/AS)
• N-Nitrosodimethylamine (PB/90/182130/AS)
• N-Nitrosodi-n-propylamine (PB/90/180258/AS)
• N-Nitrosodiphenylamine (Update) (PB/93/182509/AS)

-O-

• Otto fuel II (PB/95/264248/AS) *

-P-

• Pentachlorophenol (Update) (PB/95/100210/AS)
• Phenol (Update)
• Plutonium (PB/91/180406/AS)
• Polybrominated biphenyls (PB/95/264388)
• Polychlorinated biphenyls:  Aroclors -1260, -1254, -1248, -1242, -1232, -1221, and -1016 (Update) (PB/98/101173/AS)
• Polycyclic aromatic hydrocarbons: Acenaphthene, Acenaphthylene, Anthracene, Benzo(a)anthracene, Benzo(a)pyrene,  Benzo(b)fluoranthene, Benzo(g,h,i)perylene, Benzo(k)fluoranthene, Chrysene, Dibenzo(a,h)anthracene, Fluoranthene, Fluorene, Indeno(1,2,3-cd)pyrene, Phenanthrene, Pyrene (Update) (PB/95/264370)
• Pyridine (PB/93/110831/AS)

-Q-

None Available

Return to finalized index

-R-

• Radium (PB/91/180414/AS)
• Radon (PB/91/180422/AS)
• RDX (PB/95/264255) *

-S-

• Selenium (Update) (PB/97/121032/AS)
• Silver (PB/91/180430/AS)
• Stoddard solvent (PB/95/264263) *
• Styrene (PB/93/110849/AS)
• Sulfur Dioxide
• Sulfur Trioxide/Sulfuric Acid

-T-

• 2,3,7,8-Tetrachlorodibenzo-p-dioxin (PB/89/214522/AS)
• 1,1,2,2-Tetrachloroethane (Update) (PB/97/121099/AS)
• Tetrachloroethylene (Update) (PB/98/101181/AS)
• Tetryl (PB/95/264271/AS) *
• Thallium (PB/93/110856/AS)
• Thorium (PB/91/180448/AS)
• Tin (PB/93/110864/AS)
• Titanium tetrachloride (PB/98/101082/AS) *
• Toluene (Update) (PB/95/100228/AS)
• Toxaphene (Update) (PB/97/121057/AS)
• 1,1,1-Trichloroethane (Update) (PB/95/264396)
• 1,1,2-Trichloroethane (PB/90/196411/AS)
• Trichloroethylene (Update) (PB/98/101165/AS)
• 2,4,6-Trichlorophenol (PB/91/181545/AS)
• 1,2,3-Trichloropropane (PB/93/110872/AS)
• 2,4,6-Trinitrotoluene (PB/95/264297/AS) *

-U-

• Uranium (PB/91/180471/AS)

-V-

• Vanadium (PB/93/110880/AS)
• Vinyl acetate (PB/93/110898/AS)
• Vinyl chloride (Update) (PB/98/101132/AS)

-W-

• White Phosphorus (PB/98/101090/AS) *

-X-

• Xylenes (Update) (PB/95/264404)

-Y-

None Available

Return to finalized index

-Z-

• Zinc (Update) (PB/95/100236/AS)

Aluminum (Update)
Cadmium (Update)
Chlorophenols (Update)
Ethylbenzene (Update)
Formaldehyde
Hexachlorocyclohexane (Update)
Hexachlorocyclopentadiene
Hexane
Hydrogen Sulfide
Lead (Update)
Manganese (Update)

The CERCLA Set 10 toxicological profiles were made available for public comment on October 17, 1997. The public comment period ended on February 17, 1998.  The profiles are being revised based on relevant public comments.

 Return to Draft Index

*Mercury (Update)

*The final profile for mercury is scheduled to be released in March 1999.

 Return to Draft Index

Arsenic (Update)
Chromium (Update)
Endosulfan (Update)
Ethion
Methylene Chloride (Update)
*PCBs (Update)
Toluene (Update)

The CERCLA Set 12 toxicological profiles were made available for public comment on October 17, 1998. The public comment period ended on February 22, 1999 and the profiles will be revised based on relevant public comments.  *The PCBs public comment period is scheduled to end on April 26, 1999 and the profile will be revised based on relevant public comments.

 Return to Draft Index

Asbestos (Update)
Benzidine (Update)
1,2-Dichloroethane (Update)
DDT and isomers (Update)
Di-N-Butyl Phthalate (Update)
Methyl Parathion (Update)
Pentachlorophenol (Update)
Perchlorates

These profiles will be released for public comment on October 17, 1999.

Return to Draft Index
 

Total petroleum hydrocarbons (TPH)

The TPH profile was made available for public comment on October 17, 1998. The public comment period ended on February 22, 1999.  The profiles will be revised based on relevant public comments.

 Return to Draft Index

Ionizing radiation
Uranium (including depleted uranium)

The DOE Set 1 toxicological profiles were made available for public comment on October 17, 1997. The public comment period ended on February 17, 1998.  The profiles are being revised based on relevant public comments.

 Return to Draft Index

Editor's note: CERCLA is the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (Superfund).

Last updated on March 17, 1999