Schambelan M, Mulligan K, Tai VW; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 20 (abstract no. We.B.181).

San Francisco General Hospital, San Francisco, CA, USA. Fax: (415) 476-4918. E-mail: morrie@sfghgcrc.ucsf.edu.

Objective: To evaluate body composition in men with HIV -associated weight loss and changes in body composition over time in HIV+ men with and without wasting. Methods: Weight and body composition in 38 HIV+ men with documented weight loss greater than or equal to 10% (mean -11.5 plus or minus 0.5 kg) were compared with HIV+ men without significant weight loss and HIV- controls with a body mass index (BMI) within a range that corresponded to the extrapolated pre-weight loss BMI in those with wasting. Changes in weight and body composition were also evaluated in patients with and without wasting in paired measurements performed 3-24 months apart. Fat and fat-free mass (FFM) were estimated by DEXA and body cell mass (BCM) by bioimpedance analysis. Results: Both BCM and fat, adjusted for height, were significantly lower in those with weight loss, and the difference in weight between this group and controls was approximately two-thirds fat. (table: see text) In the paired studies, weight change (-1.8 to +2.0 kg/month) corrolated with change in FFM (r=0.80; p is less than 0.001). The composition of both weight lost and weight gained was approximately evenly divided between fat and FFM. Conclusions: Loss of approximately equal proportions of fat and FFM in patients with HIV-associated weight loss and the composition of weight change during modest fluctuations are consistent with the expected composition of weight lost in healthy, lean individuals during moderate energy restriction. These results argue against the notion that the typical pattern of weight loss in HIV infection is one in which fat is preserved at the expense of FFM or BCM.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Body Composition
• Body Height
• Body Mass Index
• Body Weight
• HIV Infections
• HIV Seropositivity
• Humans
• Male
• Nutritional Status
• Weight Loss
• methods

Other ID:

• 96923183

UI: 102219082

From Meeting Abstracts