National Toxicology Program

CASRN: 84-74-2

Related: PEROXISOME PROJECT (DIBUTYL PHTHALATE)

Formula: C16-H22-O4

Synonyms/Common Names:

• 1,2-BENZENEDICARBOXYLIC ACID, DIBUTYL ESTER (9CI)

Known Uses:

INSECT REPELLANT FOR IMPREGNATION OF CLOTHING. PLASTICIZER. SOLVENT. TEXTILE LUBRICATING AGENT. (TDB)

Short-Term Toxicity

• PERINATAL (Dosed-Feed)  (C62022) Completed 
  • TOX-30 (NTIS No. PB95-232427)  (Toxicity Peer Review 08/00/1994)
    Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C62022B) Report Complete 
  • TOX-30 (NTIS No. PB95-232427)  (Toxicity Peer Review 08/00/1994)
    Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 2500, 5000, 10000, 20000, OR 40000 PPM R: 0, 1250, 2500, 5000, 10000, 20000 PPM (10/S/S)
• POST-WEAN (Dosed-Feed)  (C62022) Report Complete 
  • TOX-30 (NTIS No. PB95-232427)  (Toxicity Peer Review 08/00/1994)
    Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice
  • Rats: F344/N
  • Dose: IN UTERO WITH F344 RATS; SEE C62022B

Special Studies

• Absorption Disposition Metabolism Elimination (Topical Application)  (S0045) Completed 
  • Rats
• Toxicokinetic Study (Intravenous; Gavage; Intravenous; Gavage; Intravenous; Gavage)  (S0545) Completed 
  • M Mice: B6C3F1; M Mice: B6C3F1; M Rats: Sprague Dawley; M Rats: Sprague Dawley; M Hamsters: Syrian Golden; M Hamsters: Syrian Golden
  • Dose: PRELM MOUSE IV:40, 32 MG/KG; PO:166,2320,133 MG/KG. PRELM RAT IV:10,8 MG/KG; PO:42.9,857.1,34 MG/KG. PRELIM HAMSTER IV:20 MG/KG; PO:66.67,1333 MG/KG. FEED STUDIES ALL SPECIES: 1000 & 20000 PPM. SA MOUSE IV: 30 MG/KG; PO:83,166,332 MG/KG. SA RAT IV:20 MG/KG PO:20,60,200 MG/KG. SA HAMSTER IV:20 MG/KG; PO:67,135,270 MG/KG.
• Toxicokinetic Study (Dosed-Feed)  (S0580) Completed 
  • M Rats: Sprague Dawley; M Mice: B6C3F1; M Hamsters: Syrian Golden
  • Dose: 14D: HAMSTERS 100, 2500, 5000, 10000 OR 20000 PPM; 90D: RATS & MICE 1000, 2500, 5000, 10000, 20000 PPM

Genetic Toxicology

• Mouse Lymphoma  (800748) Completed 
  •  Positive 
• Micronucleus  (A17278) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (077089) Completed 
  • Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
  •  Negative 

Organ Systems Toxicity

• Continuous Breeding Selected (R10987)  
  • Rats: Wistar Han
• Continuous Breeding (Gavage)  (RACB20107A) Completed 
  • M/F Rats: SD And Wistar
  • Dose: 600 MG/KG/DAY
• CONT EXPOS, 120 D MINIMUM Continuous Breeding (Dosed-Feed)  (RACB83084) Completed 
  • NTIS No. PB85-144798
    Citation: Final Report - Di (n-butyl) phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed
  • M/F Mice: Swiss
  • Dose: N/A; 0..03,.3,1.0%; N/A; N/A
• > 120 DAYS Continuous Breeding (Dosed-Feed)  (RACB89012) Completed 
  • NTIS No. PB92-111996
    Citation: Final Report on the Reproductive Toxicity of Di-N-Butyl Phthalate in Sprague-Dawley Rats
  • M/F Rats: Sprague Dawley
  • Dose: 0.1,0.5,1.0,1.5,2.0%; 0,.1,.5,1.0%; 0,1%; 0,.1,.5,1.0%
• Continuous Breeding (Dosed-Feed)  (RACB97003) Completed 
  • NTIS No. PB2003-100084
    Citation: Dibutyl Phthalate: Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats in the Diet (2 volumes)
  • M/F Rats: Sprague Dawley
  • Dose: 0, 4, 10, 30, 100, 1000, OR 10,000 PPM
• GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)  (T0035A) Completed 
  • NTIS No. PB85-220143
    Citation: Screening of Priority Chemicals for Potential Reproductive Hazard
  • F Mice: Swiss
  • Dose: 2500 MG/KG BODY WT.