Testing Status of Agents at NTP
Dibutyl phthalate
CASRN: 84-74-2
Related: PEROXISOME PROJECT (DIBUTYL PHTHALATE)
Formula: C16-H22-O4
Synonyms/Common Names:
- 1,2-BENZENEDICARBOXYLIC ACID, DIBUTYL ESTER (9CI)
Known Uses:
INSECT REPELLANT FOR IMPREGNATION OF CLOTHING. PLASTICIZER. SOLVENT. TEXTILE LUBRICATING AGENT. (TDB)
Short-Term Toxicity
- PERINATAL (Dosed-Feed)
(C62022) Completed
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice - Rats: F344/N; Mice: B6C3F1
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
- 13-WEEK (Dosed-Feed)
(C62022B) Report Complete
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 2500, 5000, 10000, 20000, OR 40000 PPM R: 0, 1250, 2500, 5000, 10000, 20000 PPM (10/S/S)
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
- POST-WEAN (Dosed-Feed)
(C62022) Report Complete
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
Toxicity Studies of Dibutyl Phthalate (CAS No. 84-74-2) Administered in Feed to F344/N Rats and B6C3F1Mice - Rats: F344/N
- Dose: IN UTERO WITH F344 RATS; SEE C62022B
- TOX-30 (NTIS No. PB95-232427)
(Toxicity Peer Review 08/00/1994)
Special Studies
- Absorption Disposition Metabolism Elimination (Topical Application)
(S0045) Completed
- Rats
- Toxicokinetic Study (Intravenous; Gavage; Intravenous; Gavage; Intravenous; Gavage)
(S0545) Completed
- M Mice: B6C3F1; M Mice: B6C3F1; M Rats: Sprague Dawley; M Rats: Sprague Dawley; M Hamsters: Syrian Golden; M Hamsters: Syrian Golden
- Dose: PRELM MOUSE IV:40, 32 MG/KG; PO:166,2320,133 MG/KG. PRELM RAT IV:10,8 MG/KG; PO:42.9,857.1,34 MG/KG. PRELIM HAMSTER IV:20 MG/KG; PO:66.67,1333 MG/KG. FEED STUDIES ALL SPECIES: 1000 & 20000 PPM. SA MOUSE IV: 30 MG/KG; PO:83,166,332 MG/KG. SA RAT IV:20 MG/KG PO:20,60,200 MG/KG. SA HAMSTER IV:20 MG/KG; PO:67,135,270 MG/KG.
- Toxicokinetic Study (Dosed-Feed)
(S0580) Completed
- M Rats: Sprague Dawley; M Mice: B6C3F1; M Hamsters: Syrian Golden
- Dose: 14D: HAMSTERS 100, 2500, 5000, 10000 OR 20000 PPM; 90D: RATS & MICE 1000, 2500, 5000, 10000, 20000 PPM
Genetic Toxicology
- Mouse Lymphoma
(800748) Completed
- Positive
- Micronucleus
(A17278) Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(077089) Completed
- Citation: Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
- Negative
Organ Systems Toxicity
- Continuous Breeding Selected (R10987)
- Rats: Wistar Han
- Continuous Breeding (Gavage)
(RACB20107A) Completed
- M/F Rats: SD And Wistar
- Dose: 600 MG/KG/DAY
- CONT EXPOS, 120 D MINIMUM Continuous Breeding (Dosed-Feed)
(RACB83084) Completed
- NTIS No. PB85-144798
Citation: Final Report - Di (n-butyl) phthalate: Reproduction and Fertility Assessment In CD-1 Mice When Administered in the Feed - M/F Mice: Swiss
- Dose: N/A; 0..03,.3,1.0%; N/A; N/A
- NTIS No. PB85-144798
- > 120 DAYS Continuous Breeding (Dosed-Feed)
(RACB89012) Completed
- NTIS No. PB92-111996
Citation: Final Report on the Reproductive Toxicity of Di-N-Butyl Phthalate in Sprague-Dawley Rats - M/F Rats: Sprague Dawley
- Dose: 0.1,0.5,1.0,1.5,2.0%; 0,.1,.5,1.0%; 0,1%; 0,.1,.5,1.0%
- NTIS No. PB92-111996
- Continuous Breeding (Dosed-Feed)
(RACB97003) Completed
- NTIS No. PB2003-100084
Citation: Dibutyl Phthalate: Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats in the Diet (2 volumes) - M/F Rats: Sprague Dawley
- Dose: 0, 4, 10, 30, 100, 1000, OR 10,000 PPM
- NTIS No. PB2003-100084
- GD 7-14 Short-Term in vivo Repro. Tox. (Gavage)
(T0035A) Completed
- NTIS No. PB85-220143
Citation: Screening of Priority Chemicals for Potential Reproductive Hazard - F Mice: Swiss
- Dose: 2500 MG/KG BODY WT.
- NTIS No. PB85-220143
Web page last updated on January 22, 2009